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Omega-3-Fatty Acids: A Supportive Remedial Therapy for Type 2 Diabetes Mellitus

Omega-3-Fatty Acids: A Supportive Remedial Therapy for Type 2 Diabetes Mellitus

Abroo Fatima Qazi* and Din Muhammad Shaikh

Department of Physiology, Faculty of Basic Medical Sciences, Isra University Hyderabad, Pakistan.

 
* Corresponding author: abrooqazi@gmail.com

ABSTRACT

The current study aimed to investigate the antidiabetic effects of polyunsaturated Omega-3-fatty in streptozocin (65 mg/kg body weight) induced diabetic Wistar rats. Animal were assorted to five groups: negative control group A and positive control group B and experimental groups C, D and E. Experimental groups C, D and E received Omega-3-fatty acid supplemented food in 0.3g, 0.4g and 0.5g/kg bodyweight dosage for 12 weeks, respectively. These Omega-3-fatty acids treated rats showed significant decrease in blood glucose level and rise in serum insulin as compared to positive control group (P < 0.001). At the same time, they showed significantly increased expression of insulin gene along with transcription factor PDX1 in group A (P < 0.001). It was concluded that the effect of appropriate dosage of O3FAs on the transactivation of insulin gene by expressing PDX1 can be a new therapeutic strategy in managing T2DM in future.

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Pakistan Journal of Zoology

February

Pakistan J. Zool., Vol. 56, Iss. 1, pp. 01-501

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