Clinical Expression Analysis of Serum miR-29b and miR-126 in Patients with Non-Proliferative Diabetic Retinopathy
Clinical Expression Analysis of Serum miR-29b and miR-126 in Patients with Non-Proliferative Diabetic Retinopathy
Yan Liu1* and Xiao Zhang2
ABSTRACT
Circulating miRNA remains stable and can affect glucose and lipid metabolism, inflammatory response, and angiogenesis pathways in diabetic patients by participating in energy metabolism, insulin synthesis, transportation, and signal transduction. It plays a crucial role in the occurrence and development of diabetes and its complications. This study aims to systematically evaluate the efficacy and safety of integrated traditional Chinese and Western medicine in treating non-proliferative diabetic retinopathy (NPDR). Our study used a descriptive-analytical technique and established a corresponding model diagram to analyze and study diabetic retinopathy. We examined non-value-added DR based on integrated traditional Chinese and western medicine. Further analysis and research on the retina of non-value-added diabetes mellitus. Lastly, we analyzed miR-29b and miR-126 in DR. Red blood cell aggregation can lead to arteriolar embolism and uncompensated collateral circulation of retinal capillaries due to the inability to pass through capillaries with a diameter of 3.5-6.0μm. Large infarct areas can cause capillary occlusion, which manifests as a patchy and flaky fluorescent dark area on fluorescein angiography, indicating capillary perfusion-free areas. The related risk factors of DR are closely related to the patient’s overall condition, such as the course of the disease, age, blood sugar, glycosylated hemoglobin, blood lipid, and renal function. The results of this study show that MiR-29 and DR have a significant correlation, with an influence as high as 54.42%. The dysregulation of MiR-29b and Rax and the activation of the NF-κB signaling pathway may contribute to the development and progression of DR. Our study provides a foundation for future research and treatment of patients with NPDR.
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