Asma Noshad1, Mudassar Iqbal1*, Zafar Iqbal1, Hamida Bibi2, Saifullah3, Salma Bibi4, Hamid Ullah Shah1
...t these extracts possess metabolites with insecticidal attributes that could be used as a potential source for developing new and novel bio-pesticide(s)....
Haq Aman Ullah1*, Aneela Zameer Durrani2, Muhammad Ijaz2 and Aqeel Javeed3
...toxins are the secondary metabolites produced by molds particularly by Aspergillus flavus and Aspergillus parasiticus. Aflatoxin B1 is the most common metabolite highly toxic for humans and animals. In the present study contamination status of aflatoxin B1 in cotton seed cake, wanda, wheat bran and homemade concentrate mixture of dairy goats was investigated in district Lahore of Pakistan. A total of Twent...
Ibrar Khan1,2,3,*, Sadia Qayyum2, Shehzad Ahmed2, Kashif Syed Haleem2, Mujaddad-ur-Rehman1, Guang-Lei Liu3 and Zhen-Ming Chi3
...tant different secondary metabolites and organic acids. ...
Sana Irshad Khan1*, Zafar Iqbal2, Hamid Ullah Shah2 and Shaukat Hussain3
...dia for active secondary metabolites. Ethyl acetate (EtOAc) extract of PDB medium gave significant results against selected phytopathogens compared to GNB medium and selected for further study. Crude (1 µg.mL-1 ) obtained from PDB medium showed 2.50 ± 0.64 mm and 1.97 ± 0.21 mm inhibition zone against X. campestris and C. michiganensis respectively compared to positive reference (streptomycin) and negative refrence (EtOAc) using disc diffus...
Gökhan Kuş1,*, Hatice Mehtap Kutlu2, Djanan Vejselova2 and Emre Comlekci3
...ent years. Ceramide is a metabolite in sphingolipid pathway of the cells that has an ability to promote cell death in tumor cells when produced endogenously in the cells or applied exogenously. Ceramidases, which are main component of ceramide pathway catalyze metabolism of proapoptotic ceramide to anti-apoptotic sphingosine and other fatty acids. In this study we have evaluated the pro-apoptotic effect of ceranib-2, a human ceramidase inhibitor and of a short...
Sitansu Pan and Someshwar Bhagat
Biological control of plant diseases
...ain toxins and secondary metabolites, solublization and sequestration of immobilized plant nutrients, plant growth prowth promoting properties and induced resistance. Multiple interactions between bacteria-fungi-actinomycete, may exist in nature and that is why consortium of microorganisms is needed for tackling several plant pathogens simultaneously instead of only one biocontrol agent-one pathogen,which is the most common and established system of biocontrol...
Fariha Imtiaz1, Muhammad Islam1, Hamid Saeed2,*, Bushra Saleem1, Maryam Asghar1 and Zikria Saleem2
..., proteins and secondary metabolites in methanol compared to other extracting solvents. Moreover, only ethanol (5 and 10%) and petroleum ether (5%) demonstrated significant hair growth promoting effects (p < 0.05) compared to standard, i.e., 5% minoxidil and extracts in other solvents. Likewise, ethanol (5% and 10 %) and petroleum ether (5%) extract had significant impact (p < 0.05) on hair length in comparison to minoxidil, however, no significan...
Mei Li1, Di Zhang2 and Wan-Long Zhu1,*
...div>...
Tayfun Karataş
... for 8 days on the serum metabolites and antioxidant enzymes, thiobarbituric acid reacting substance levels, endogenous reserves in liver and muscle tissues of rainbow trout (Oncorhynchus mykiss). Eight-days of fasting caused a significant decrease in glucose, total protein, triglyceride, cholesterol, high-density lipoprotein and low-density lipoprotein levels as well as protein and lipid reserves in liver and muscle tissue of fish (p<0.05). The fast...
Xiaqing Chen, Yü Huang and Zhen Huang*
...e a series of antibiotic metabolites that can inhibit plant pathogens. Trichoderma hamatum isolated from infected mulberry fruits was evaluated for its efficiency to suppress plant pathogen S. shiraiana alone or in combination with fungicide carbendazim under laboratory conditions. The results showed that S. shiraiana was not detected on mulberry leaves and branches, whereas it was only detected in mulberry fruits. T. hamatu...
Dan Yü, Chuchu Li, Yü Huang and Zhen Huang*
...h by production of toxic metabolites and mycoparasitism. In vitro bioassays were used to evaluate the efficacy of T. hamatum and difenoconazole alone or its combinations against S. sclerotiorum. The results showed that T. hamatum could infect and destroy the mycelia and sclerotia of S. sclerotiorum by mycoparasitism. The cell-free culture supernatant and ethylacetate extracts from T. hamatum inhibited mycelial growth o...
Nimra Naseer, Adeela Fatima and Imran Sajid*
...tial bioactive secondary metabolites against MDR bacterial pathogens. The identification of strains was done by morphological, physiological and biochemical characterization and by 16SrRNA gene sequencing. For biological screening different methods including cross streak, agar plug and well diffusion method were performed. Seven Streptomyces strains including NWMD-6, NWMD-7, NWMD-10, NWMD-11, NWMD-12, NWMD-15 and NWMD-16 were found to have significant a...
Umair Riaz1*, Muhammad Ali Kharal2, Ghulam Murtaza3, Qamar uz Zaman4, Sana Javaid4, Hina Ahmed Malik3, Humera Aziz3 and Zafar Abbas1
...iosynthesis of secondary metabolites at cellular level which included organic compounds that help plants to cope with stress conditions by reducing the intensity of stress through enhancing antioxidants activities, detoxifying toxic ions, regulating the uptake of nutrients and by mediating the transport and distribution of different hormones. Caffeic acid is actively involved in plant physiology and mechanisms of stress tolerance primarily utilized by plants f...
Nadia Khan1*, Abdul Waheed1, Farrukh Siyar Hamid1, Naveed Ahmed1, Zafar Iqbal2, Seemab Ali1, Madiha Bashir1 and Hina Gul3
...raction of oil possesses metabolites like carbohydrates, amino acids, alkaloids, flavonoids and glycosides. To test the antibacterial activity of the extracted seed oil, Agar well diffusion assay was employed. Effectiveness of the oil against selected bacterial species was measured in terms of zone of inhibition in millimeters. Amoxicillin was used as a positive control. The results showed that Clavibacter sp. and E. coli exhibit resistant to the oil extract w...
Dilara Abbas Bukhari1, Abdul Rehman2*
Isolation of bioactive compounds from exudate of edible fungus, Pleurotus ostreatus
...tal of fifteen different metabolites were detected in the sample by GC/MS. The detected metabolites could be classified into chemical groups of 2 esters, 4 alcohols, 3 benzoic acids, ketone, aldehyde, phenyl and amide groups containing compounds. Some of these may be classified into aroma containing compounds....
Maleeha Manzoor1,2*, Ruijuan Ma2, Hafiz Abdullah Shakir1, Fouzia Tabssum1, Javed Iqbal Qazi1
Microalgal-bacterial consortium: a cost-effective approach of wastewater treatment in Pakistan
...on of producing valuable metabolites and pollutants/nutrients removal from wastes/wastewaters.
Agricultural wastes/residues generated abundantly in energy deficient countries like Pakistan, having enormous
energy potential, are not utilized efficiently and considered as wastes only. The present review focuses on the current
research on algal-bacterial consortia and the construction of consortia by keeping in view the environmental
c...
Agricultural wastes/residues generated abundantly in energy deficient countries like Pakistan, having enormous
energy potential, are not utilized efficiently and considered as wastes only. The present review focuses on the current
research on algal-bacterial consortia and the construction of consortia by keeping in view the environmental
c...
Sadaf Rahim and Mudassar Iqbal*
...produce potent secondary metabolites with antimicrobial, herbicidal, insecticidal and other such beneficial activities. Production of such compounds can be increased or decreased depending on growth conditions. For these reasons a Trichoderma harzianum was selected for its growth optimization conditions and extraction of insecticidal compounds effective against two major insects pests including Diuraphis noxia and Tribolium castaneum. The pure fungal strain of...
Riyadh S. Aljumaah1, Mutassim M. Abdelrahman1,*, Moez Ayadi1 and Abdullah H. Alyemni2
...nt important nutritional metabolites. In addition, colostrum, at parturition, and milk samples on day 30, 60 and 90 postpartum were collected for nutrient contents. The results showed an improvement in lambing rate of ewes in T1 and T2 (81 and 80%, respectively) compared to the control (78.8%). Moreover, ewes in T2 showed higher lambs survival rate and average daily gain up to 90 days. There was no significant effect (P>0.05) of treatments on the colostrum ...
Fizza Anwar1, Muddassar Zafar1*, Zahid Anwar1, Raja Tahir Mehmood2
...e produced antimicrobial metabolites included Aflatrem, Monacolin K, Fusarubin and Tautomycetin. Different fermentation parameters were optimized to produce antimicrobial agents using Response Surface Methodology (RSM) and best results were obtained at 45°C temperature, 5.5 pH, 5 mL inoculum concentration, 1.5 mL banana peel as substrate and 20 days incubation time. The antimicrobial activity of secondary metabolite
Haq Aman Ullah1,*, Aneela Zameer Durrani2, Muhammad Ijaz2, Aqeel Javeed3, Muqadder Shah1 and Ikramul Haq1
...o determine carcinogenic metabolite aflatoxin M1 (AFM1) in milk and to investigate the effects of low doses of dietary aflatoxin B1 (AFB1) on physiological biomarkers with special reference to udder health and serum parameters of lactating goats. Thirty two lactating Beetal goats of 3-4 y age, weighing 40.91±0.285, were randomly selected, and equally divided into four groups. Group A was kept as control while animals of groups B, C, and D were individua...
Barkat Ali1,2, Wasim Sajjad1,2,3, Imran Khan1, Muhammad Rafiq1, Sahib Zada1, Aamer Ali Shah1 and Fariha Hasan1,*
... a repository of certain metabolites that might be able to solve the problem of increasing resistance against antibiotics. The present study was designed to isolate endolithic and epilithic bacterial strains from the rapidly weathering rocks collected from Nathiagali, Pakistan to characterize and screen them for antimicrobial activity. The isolates were identified based on 16S rRNA sequence analysis. Antibacterial activity of the isolates was checked against A...
Erum Yawar Iqbal1*, Ashfaque Ahmed Nahiyoon1, Shahnaz Dawar2 and Shahina Fayyaz1
...potential to release its metabolites with insecticidal mode of actions in the surrounding culture media. New species proficiency was evaluated in comparison with other indigenous isolates and resulted in most efficient at 30ºC after 24h and proved to have good effectiveness as biological control agent and can be easily used instead of live bacteria in future formulations.
...
Sana Aslam1, Wayne Thomas Shier2 and Imran Sajid1*
...aracterize the bioactive metabolites produced by them. A total of seventy strains of actinomycetes were isolated from lake samples, out of them only forty bioactive strains were selected for further characterization on the basis of their preliminary antimicrobial activities. The isolated actinobacterial strains showed an optimum growth at alkaline pH (9.0-9.5). The taxonomic analysis revealed that these isolates were closely affiliated with the genus Strept...
Mohammad Ejaz1, Salma Javed2, Muhammad Hamza1, Sadia Tabassum2, Muhammad Abubakar3, Irfan Ullah4*
...e molecules or secondary metabolites secreted by fungal endophytes as novel sources of anticancer drugs. The main purpose of this review is to organize the effective compound of the fungal endophytes for cancer treatments.
...
Hifzulrahman1, Muhammad Abdullah1*, Muhammad Uzair Akhtar2, Jalees Ahmed Bhatti3, Muhammad Saadullah1 and Muhammad Naveed-ul-Haque2
...uction, milk fat, plasma metabolites, and reproductive parameters in early-lactating Nili Ravi buffaloes. Sixteen early-lactating Nili Ravi buffaloes received 2 treatments in a completely randomized design with a period length of 120-d. The treatments were 1) Ctrl = basal diet without supplementation of fat, 2) Ca-FA = basal diet with calcium salts of palm fatty acids supplementation. The Ca-FA treatment increased the 3.5% fat-corrected milk yield by 11.0% com...
Hui-Ying Chen1,2*, Ping-Chuan Yin1,2, Ya-Nan Lu1,2, Hai-Yun Li1,2*and Yang Shan3
... implicated in secondary metabolite biosynthesis, carbon metabolism and antibiotic effects. The results revealed that the substance exhibited abundant biosynthesis and glycolysis/gluconeogenesis. Subsequently, the following top 10 hub genes were identified to the PPI network: Guanine nucleotide-binding protein subunit β, ribosomal 60S subunit protein (RPL) 8A, RPL9A, RPL6B, ribosomal 40S subunit protein (RPS) 9B, RPL31B, RPL27B, RPS14B, RPL22B and RPL22A....
S. Ahmed† , L. Yue, Q. Liu and H. Jian
Evaluation of media for mass production and fermentation of Pseudomonas spp. for integrated management of cereal cyst nematode (Heterodera avenae)
...red to rest of secondary metabolites produced in different media and control treatments. All tested strains of Pseudomonas spp. showed stability on pH ranges from acidic pH5 to neutral pH7 and towards basic pH8 against the second stage juvenile (J2) mortality assay. ...
Agustine Christela Melviana1, Rizkita Rachmi Esyanti1*, Roy Hendroko Setyobudi2, Maizirwan Mel3, Praptiningsih Gamawati Adinurani4 and Juris Burlakovs5
Gene Expression Related to Steviol Glycoside Synthesis Produced in Stevia rebaudiana (Bert.) Shoot Culture Induced with High Far-Red LED Light in TIS RITA® Bioreactor System
...ors interfering with the metabolite production, as the content of steviol glycoside will decrease after plant flowering dramatically. This mechanism happened because steviol glycoside synthesis and flowering process share the same precursor. However, this interfering factor could be inhibited by using a high-red LED induction to delay the flowering stage, which may contribute to higher biomass and glycoside concentrations through greater system productiv...
Sajid Ali1, Abdul Basit1,3*, Abdul Mateen Khattak1, Syed Tanveer Shah1, Izhar Ullah2, Noor Alam Khan3, Imran Ahmad1, Kamran Rauf1, Salman Khan1, Irfan Ullah1 and Intizar Ahmad1
Managing the Growth and Flower Production of Zinnia (Zinnia elegans) through Benzyle Amino Purine (BAP) Application and Pinching
...generally act as a plant metabolite and growth retardant. It encourages the growth and cell division of dormant buds and bushiness of plant by reducing its height. Similarly, pinching of terminal branches increase the cytokinins and decrease auxin concentrations flourishing the axillary buds. A research study on the growth and production of zinnia flowers through application of BAP (25, 50, 75 and 100 mg L-1) and pinching (2, 4 and 6 leaf stages), was carried ...
Wenyou Huang1, Dan Yü1, Song Huang1,2, Jian Xiao2, Ping Qi2, Anhua Song2* and Zhen Huang1*
...growth selection, second metabolites change and insect bioassays using Plutella xylostella larvae as the host resulted in the isolation of a collection of mutants with increased virulence. One mutant, designated, MlUV-40b showed ＃3.3-fold increase in virulence as compared to the wild type parent, with an LC50 = 0.3 ...
Saba Shabeer1, Riffat Tahira2 and Atif Jamal3*
...angerous secondary toxic metabolites, which are commonly known as mycotoxins. Some of the important toxins produced by different species of Fusarium are fumonisins and trichothecenes.Fusarium species are present around the world and have a very wide host range including many economically important species of crops and plants. Most of the plant diseases are caused by F. solani, F. oxysporum and F. graminearum. Fusarium...
Aneeqa Saleem1, Muhammad Islam1, Hamid Saeed1* and Mehwish Iqtedar2
...to primary and secondary metabolites between both peel and pulp extractives. After 21 days of treatment in mice, only chloroform (CHL) extractives of peel and pulp demonstrated significant improvements in serum creatinine (Peel: N; 1±0.44, PC; 1.4±0.62, CHL; 0.43±0.18, p<0.05, Pulp: CHL; 0.8±0.26, p<0.05) and BUN levels (Peel: N; 13.2±0.53, PC; 9.1±0.97, CHL; 9.4±0.84,
Qaiser Shakeel1*, Rabia Tahir Bajwa1, Yasir Iftikhar2, Mustansar Mubeen2, Muhammad Luqman3, Waqas Ashraf1 and Ifrah Rashid4
...lants are rich source of metabolites with a wide range of antifungal activity against ginger soft rot. Crude extracts of these plants have potential to become effective biopesticides upon purified fractions with no hazardous effects on environment as well as humans....
Fahrauk Faramayuda1,2*, Totik Sri Mariani3, Elfahmi1,4 and Sukrasno1
...is to identify secondary metabolite in callus using thin layer chromatography (TLC). The profiling of ethanol extracts of callus of two varieties O. aristatus were carried out using solvent system toluene-ethyl acetate- formic acid-water (3:3:1:0.2). The results of monitoring TLC suggest that callus obtained from Schenk and Hildebrandt (SH) media can proceed to the suspension culture stage because it showed brighter fluorescence spot than other callus an...
Aliya Munir1, Sajid Abdullah1*, Huma Naz2*, Khalid Abbas1, Tanveer Ahmed3 and Zahid Farooq2
... of pesticides and their metabolites in freshwater bodies. Pesticides can trigger stress in organisms by increasing the number of reactive oxygen species. Oxidative stress biomarkers like antioxidants enzymes have been successfully used in ecotoxicology field for evaluating the stress response of organisms exposed to pollutants. Therefore, this work was designed to evaluate the peroxidase (POx) level in kiney, gills and liver of fish Channa striata exposed to ...
Fahrauk Faramayuda1,2*, Totik Sri Mariani3, Elfahmi1,4 and Sukrasno1
...ntain the same secondary metabolites as the wild type. This study aims to identify the chemical content of two varieties of O. aristatus resulting from in vitro culture. The five-month-old variety of O. aristatus purple and white purple and wild type was extracted using two solvents with different polarity levels, namely ethanol and ethyl acetate. The concentrated extract was identified for its chemical content using gradient system HPLC 0.1% formic acid: acet...
Sonam Khatri1, Shaheen Faizi2, Shahina Fayyaz1 and Erum Iqbal1*
...ynthis and the secondary metabolites isolated from the plant i.e. alcohols, esters, fatty acids terpenes, flavonoids and steroids are assembled in this article which further provide a basis for a noteworthy nematicidal effect....
Khlood G. Abdelkhalek*, Aly B. A. Badawy, Mohamed Fathi, Elshymaa A. Abdelnaby
..., and serum nitric oxide metabolites (NOMs) were measured in 5 Baladi bucks weighting (13–15 kg; with a body condition score of 3.5 ± 0.01) from 4-months- to 10-months-old in relation to testicular hemodynamics. Testicular morphometry, scrotal circumference, Doppler examinations, image analysis, and blood sampling were performed on a weekly basis. Results showed that FSH level was elevated (P<0.05) firstly from 5-months to 6.5-months-old, and t...
Sadarman1, Agung Irawan2, Muhammad Ridla3, Anuraga Jayanegara3*, Nahrowi3, Roni Ridwan4, Ahmad Sofyan5, Hendra Herdian5, I Nyoman Guna Darma5, Teguh Wahyono6, Dewi Febrina1, Rakhmad Perkasa Harahap7, Rizki Amalia Nurfitriani8, Danung Nur Adli9
...nnins (HT) are secondary metabolites substances that are widely proposed as safe additives to improve protein utilization in ruminants. This study aimed to investigate the effect of tannins extracted from acacia and chestnut on the degradation kinetics of ensiled and non-ensiled soy sauce residue (SSR) in sacco. Two fistulated beef cattle (425±25 kg) fed a diet consisting of 80% Pennisetum purpureum and 20% concentrate was used to incubate the SSR sampl...
Ali Ikhwan1*, Dian Indratmi1, Faridlotul Hasanah1, Manar Fayiz Mousa Atoum2,3 and Irum Iqrar4,5
...of purple cleome extract metabolites and understand their effectiveness in inhibiting C. capsici. Purple cleome leaf is extracted with 1:1 w/v absolute methanol and concentrated with 1:1 v/v cold absolute methanol, and then the supernatant is purified using a centrifuge. The metabolic analysis was performed using Gas Chromatography-Mass Spectrometry (GC-MS) and comparing the data with the National Center for Biotechnology Information (NCBI) database to ...
Ahmed M. Elbaz*, Engy F. Zaki, Morsy A. S.
...in on performance, blood metabolite, and meat quality in broiler chickens. A total of four hundred and eighty 1-day-old Ross 308 chicks were randomly divided into four experimental groups: Control (CON), 5% of quinoa seeds (QS5), 10% of quinoa seeds (QS10), and 15% of quinoa seeds (QS15) groups. Results indicated that increasing inclusion levels of QS improved body weight gain, feed conversion ratio, and crude protein digestibility of broiler chickens. Includi...
Fulencio Ferretiz-Rodríguez1, Jose Alejandro Roque-Jiménez1, Héctor A. Lee-Rangel1*, Gregorio Alvarez-Fuentes1, Juan Carlos Garcia-Lopez1, Rolando Rojo-Rubio2
...airy cows production and metabolites change. Thirty-two Holstein cows (Body Condition Score 3.01 ± 0.16) fed a basal diet, were randomly assigned to one of four treatments: Control diet, Biocholine (BIO) supplementation (15 grams/cow/day), Optimethionine (OP) supplementation (9 grams/cow/day), and BIO x OP supplementation, with a duration of 60 days. Optimethionine treatments decrease milk production (P ≤ 0.05), but fat corrected production was highe...
Zein Ahmad Baihaqi1,2, Irkham Widiyono3*, Bambang Suwignyo4, Amado A. Angeles5
...s by utilizing secondary metabolite compounds in plants. These studies are interesting to be continued and explored in an effort to reduce methane production through in vitro and in vivo, because it is proven that there are many types of biological or agro-industrial waste in the world different contents, structures and benefits. This review of the last 5 years related to the utilization of tannin active compounds showed the effect on the reduction of methane ...
Naila Shahzadi1, Hafiz Muhammad Tahir1*, Shaukat Ali1, Muhammad Farooq Bhatti2, Azizullah1, Shafaat Yar Khan3, Abdul Khaliq4
...powder, AgNPs, secondary metabolites (phenols flavonoids, phenolic amino acids and proline) and white hen’s egg at different larval instars. Economic parameters (pupal weight, shell ratio (%), cocoon weight, filament length, shell weight, denier, fibroin and sericin contents) and biological traits (fresh weight of each larva, silk gland, pupa and moth) of silkworm, Bombyx mori L. (Lepidoptera: Bombycidae) have been enhanced with natural food supplements....
Aiman Al Mufarji, Abd El-Nasser Ahmed Mohammed*
Oluwatoyin Adenike Fabiyi
...">Pesticide residues and metabolites are often found in fruits, vegetables, soil and underground water as contaminants. This necessitated the search for bio-nematicides, accordingly the nematicidal prospect of chromatographic fractions from Mangifera indica as a substitute to synthetic nematicides in the control of Meloidogyne incognita pests of tomato was evaluated. Crude extracts of M. indica bark was fractionated on silica-gel (120-150 mesh) using glass col...
Aiman Al Mufarji1, Abd El-Nasser Ahmed Mohammed1*, Rashid Al Zeidi2, Haitham Al Masruri3
...rmo-tolerance responses, metabolites, and liver and kidney functions. M. oleifera supplementation with a rate of 50 and 100 g to stressed ewes especially during high ambient temperatures and in subtropics is recommended.
Keywords | Blood, Heat stress, Moringa oleifera, Metabolites, Plasma
...
Umar Farooq Gohar, Attia Majeed, Bushra Muneer* and Hamid Mukhtar
...ally important secondary metabolites....
Hazem E. M. Hassanien1*, Awad M. M. Mahmoud2, Elsayed M. Abdel-Raouf1, Nabil M. Eweedah1 and Midhat. N. Nassif3
...ed iCa, blood, and rumen metabolites, and endocrine status in prepartum and postpartum phases. Forty-eight multiparous Holstein cows range lactation 1-5 with an average body weight 706 kg ±7.29 SD were enrolled in a nested block design trial at 29 d prior anticipated parturition through 90 d in milk. A factorial arrangement of treatments -3 DCAD concentrations Tr1. (0.0, -100 or -180 mEq/kg DM) and -2 postpartum DCAD concentrations Tr2. (+250 or +350 mE...
Shomaila Sikandar1*, Imran Afzal1 and Sadaf Sarfraz2
...toxins are the secondary metabolites produced by different filamentous fungi. The significance of these low molecular weight compounds lies in the fact that they are the contributors of severe health issues in livestock and humans. Every year mycotoxins infect different crops and animal feedstock by accumulating in the food and feed crops in the field and during transportation, which leads to the huge economic losses. Presently about 300 types of mycotoxins ha...
Shou-Dong Zhang1,2,3, Dao-Xin Liu1,2, Dan Mou1, Tong-Zuo Zhang2, Jian-Ping Su2 and Jiu-Xiang Xie1*
...ntageous secondary plant metabolites....
Hossam Mahrous Ebeid1, Ahmed Abdelkader Aboamer1*, Amgad Ahmed Abu Elella2, Ibrahim Mohamed Khattab3, Osama Hefny Matloup1, Fatma Ibrahim Hadhoud1
...’s effect on blood metabolites and quality and quantity of the produced milk. Treatment groups were provided either a control diet or control diet with 40 g/head/day (DMSC40) or 80 g/head/day (DMSC80) of DMSC. DMSC was high in protein (39.6% CP on DM) and low in fibre. DMSC DM was thought to be highly digestible due to its high ruminally degradable fraction (76.1%). Increasing supplementation amount of DMSC in goats’ diets reduced their blood chole...
Siriporn Namted, Kanokporn Poungpong, Wiriya Loongyai, Choawit Rakangthong, Chaiyapoom Bunchasak*
...d some of their cellular metabolites are key beneficial factors in promoting the growth performance, immunological response, gut morphology, gut microbiota, and feed consumption of pigs.
Keywords | Yeast extract, Yeast cell wall, Performance, Immune, Pig
...
Qingyue Han1, Ying Li1, Jichang Deng1, Kunxuan Huang1, Yanyang Yang1, Quanwei Li1, Zhuowei Zhang1, Na Qiao1, Yanju Ji2, Khalid Mehmood3, Sarfaraz Ali Fazlani4, Hui Zhang1 and Zhaoxin Tang1*
...cts of vitamin D and its metabolites on heart development in swine. The effect of 25(OH)D3 and Ca2+ supplementation in diets on heart development in neonatal piglets during pregnancy were examined in this study. Total 40 sows of 7 gestational age with good health and nutritional condition were divided into four groups (n=10): the control group, low calcium, 25(OH)D3 group and low calcium with 25(OH)D3 group. Each groups consist of 5 piglets, randomly selected ...
Serkan Özkaya1*, Oktay Özkan2, Sabri Erbas3, Isa Gökhan Yalçın4, Dariusz Piwczynski5 and Wojciech Neja5
S. Ahmed†, Q. Liu and H. Jian
...eus strain B48 secondary metabolite with protease and chitinase
activity was used as seed bacterization in green house experiments. In green house significant reduction in white
female development was observed for avermectin (84.53%) followed by B. cereus strain B48 (78.10%) as compared
to results of the untreated control treatment (P≤0.05).
...
R. Singh1† and R. Z. Sayyed2
... localization of various metabolites in
normal and galled roots of sponge gourd, Luffa cylindrica L., infected with root-knot nematode Meloidogyne
incognita. Histochemistry of the roots revealed an increase in protein, nucleic acids (RNA and DNA) and
amylodextrin (hydrolyzed starch) concentration in the infected regions as compared with normal healthy sections.
Protein localization found more pronounced at the si...
Hina Safdar1,2*, Nazir Javed2, Sajid Aleem Khan2, Muhammad Zeeshan Majeed3, Arif Mehmood3 and Muhammad Arshad4
...ated with EPNs and their metabolites. In this laboratory study, two bacterial isolates i.e. Xenorhabdus spp. associated with EPN Steinernema glaseri (Steiner) (Steinernematidae) and Photorhabdus spp. associated with EPN Heterorhabditis bacteriophora (Poinar) (Heterorhabditidae), were evaluated against armyworm Spodoptera litura Fabricius (Lepidoptera: Noctuidae) which is a destructive lepidopterous pest. These EPNs associated bacterial isolates were applied @ ...
Shaker Al-Suwaiegh
...th performance and blood metabolites of growing Ardi goats were explored. Twenty one growing Ardi goats, 27.0 ± 0.40 kg body weight and aged 4.0 - 5.0 months, were randomly allocated to three equal groups (seven/group) as Azolla pinnata (10.0 and 20.0 % daily feed) and control groups. The trial lasted 12 weeks. Feed intake, feed efficiency, and body weight gain were determined. In addition, nutrients’ digestibility were determined. Blood samples w...
Aiman Al-Mufarji, Shaker Al-Suwaiegh, Abd El-Nasser Mohammed*
Songruo Tao1, Cuiyi Liao1, Jinju Peng1, Yuexia Ding1,* and Yi Ma1,2,*
...terial diseases, most of metabolites enter the soil in the form of metabolites in feces or urine and pollute environment. Soil ecological model was established by experiment to investigate the effects of florfenicol residues in soil on 16S rDNA sequence diversity of phosphorus-solubilizing bacteria. Five different concentrations of florfenicol (0 mg·kg-1, 0.1 mg·kg-1, 1 mg·kg-1, 10 mg·kg-1 and 100...
SYED ZULFIQAR ALI ABIDI, HAFIZ ABDULLAH SHAKIR, SYED SHAHID ALI, & JAVED IQBAL QAZI*
...Plants produce different metabolites and some of them are used for antimicrobial, fungicidal, herbicidal, piscicidal and molluscicidal. The present study was aimed to find out metabolites of piscicidal potential. Total thirty plants were collected on the basis of their availability and abundance around the year from different locations of Punjab, Pakistan. The aqueous and alcoholic extract of fresh and dried parts of each pl...
Yang Hu, Jingxin Ding, Beilei Xu, Xiangming Sun, Guoyu Li, Hui Song, Zheng Zong and Wenlan Li*
... parent molecules and 64 metabolites. The serum fingerprint of TGs were established, and 36 common peaks were identified. The correlation coefficient and the Grey relational degree between the relative area of the common peaks and the estrogen-like activity of TGs were determined through bivariate analysis and Grey relational analysis, respectively. Total 32 chemical components were identified, including methylated cistantubuloside B, acetylated tubuloside B, ...
Anhar Ibrahim Elhanafy*, Amr Mohamed Mousa, Amaal Mohamed Kamal
...enom (BV) affected blood metabolites, hematology, immunity, oxidative stress and thyroid hormones in doe rabbits at high ambient temperature. Forty mature female New Zealand White rabbits (6 months age) were divided into four groups. Three of them (0.1, 0.2 and 0.3 mg/doe) represent different concentrations of BV, while the fourth group was control. Twice weekly injections of does were carried out along 12-weeks. Results revealed that BV treated does were sign...
Jawad Ali1,*, Samiya Rehman1, Aqsa Aslam1, Fouzia Tanvir2, Rida Liaqat1, Muhammad Ahmad1, Aamir Riaz1, Muhammad Shafique3, Hassan Ali1 and Amjad Ali1
...ce elements as secondary metabolites imparts antidiabetic, hepatoprotective, hypolipidemic, antidepressant, immunosuppressive, anti-microbial properties to the W. coagulans Dunal. Plant samples from Mianwalli, Kohat, and Sargodha city were gathered for antioxidant potential determination. Free radical scavenging activity and total antioxidant activity experiments were performed on the samples using the DPPH and Phosphomolybdenum methods. Results shows leaves e...
Mati Ullah1*, Muhammad Rizwan2, Ali Raza3, Xianlin Zhao4, Yanling Sun4, Sarah Gul5, Muhammad Ihtesham Waheed6, Muhammad Nadeem Khan7, Alvina Gul8, Sami Ullah Jan9* and Chao Huang4*
...iosynthesis of secondary metabolites pathway” as the dominant one. Similarly, the functional characterization by eggNOG database revealed that the COGs associated with “Carbohydrate transport and metabolism” were dominant. These find-ings provide a broader understanding of the genome features as well as their functional characterization of the famous probiotic bacterial group....
SHEHLA AKBAR*, SAIQA ISHTIAQ*, KHALID HUSSAIN, ANS MUNIR & SAIRA REHMAN
...s. Primary and secondary metabolites of Misopates
orontium (L.) belongs to Plantaginaceae family were screened out and
tested for therapeutic values through in-vitro biological assays.
Quantitative analysis was done on powder of Misopates orontium by
using standard methods for estimating the primary and secondary
metabolites. The maximum value of total carbohydrates...
KHADIJA SUMMIA*1, ROHEELA YASMEEN*2, ALEEM UN NISA3, SAMIA DJEFFAL4 & TAHIRA JABEEN1
...xins. They are secondary metabolites and their main producing agents are Aspergillus flavus, Aspergillus nomius and Aspergillus parasiticus that are famous for Aflatoxin B1, B2, G1, and G2. The present study was conducted to quantify the aflatoxins in bovine feed provided to cattle found in and around Lahore. Total 50 samples were collected from two different localities of Lahore and categorized in two groups: Group A (Raiwind, 30 samples), Group B (Bedian Roa...
Shaker B. Al Suwaiegh
...cal parameters and serum metabolites were investigated during the study. The results indicated that the diets with high percentage of giant reed (40.0 & 50.0%) were decreased (P<0.05) the most recorded parameters compared to the control and 30.0% giant reed diets under subtropical condition. In conclusion, replacement of alfalfa hay with 30.0% giant reed could be promising of Ardi goat growth performances, feed efficiency and serum
Hafiza Mehwish Iqbal1, Salman Khurshid1*, Saqib Arif1, Qurrat-ul-Ain Akbar1, Saba Iqbal2, Shahid Yousaf3, Kainat Qureshi1, Abdul Karim Khan5, Abdul Ahad6, Aqeel Ahmed Siddique4 and Neelofar Hamid7
...imicrobial and secondary metabolites activities has gained tremendous attention from researchers. ...
Turrini Yudiarti*, Sugiharto Sugiharto, Endang Widiastuti, Hanny Indrat Wahyuni, Tri Agus Sartono, Maulana Hamonangan Nasution
...y produce many secondary metabolites that has been shown improve the nutritional quality, antibacterial properties and antioxidant activity.The obyective of this study was to see how adding the fermented product of the fungus Monascus purpureus as a feed additive affected to physiological parameters, intestine microbial population, and broiler internal organ weight. The method was one hundred and fifty un-sexed one-day-old chicks (DOC) were reared in an open c...
Tariq I. Almundarij
...ion score (BCS) on blood metabolites and hormones and their link with the occurrence of reproductive abnormalities in female dromedary camels. To determine their link with two different ages of the Majaheem (black) and Waddah (white) breeds, measurements of lipogram and antioxidant parameters were assessed. During the breeding season, 16 dromedary she-camels that appeared to be in good health included in this study as controls. Their average body weight ranged...
Luthfiralda Sjahfirdi1*, Lisa Nurfalah1, Deanvi Fahira Wisnuputri1, Entang Iskandar2
...diol-3-glucuronide (PdG) metabolite hormone levels in feces, was performed as a success parameter of ex-situ conservation in the breeding facility. Behaviors of two adult female N. hilleri (K2 and K5) were observed in their cages from 17:00 to 05:00 WIB from September to November 2015. Feces were collected during the observation period and the levels of E1C and PdG were analyzed by enzyme-linked immunosorbent assay (ELISA). Our results showed that the average ...
Nael Abutaha, Fahd A. AL-Mekhlafi*, Khalid Elfaki Ibrahim,
Mohammed S. Al-Khalifa and Mohamed A. Wadaan
...the fruit. The secondary metabolites were identified using phytochemical analysis and gas chromatography-mass spectrometry (GC-MS). The cytotoxic effect was also evaluated using normal human umbilical endothelial cells (HUV-EC). The larvicidal assay was performed on the third instar stage as recommended by WHO. The phytochemical analysis showed the presence of alkaloids, sterols, and phenolic compounds. The GC-MS analysis revealed the presence of 5 compounds, ...
Sudeb Saha1,2*, Jay Prakash Ray3, Apurbo Kumar Mondal4, Md. Irtija Ahsan5, Marina Debnath6, Dilruba Afrin7, Syed Sayeem Uddin Ahmed5, Jayanta Datta Gupta3, Nivedita Datta8, Hugo O. Toledo-Alvarado9, Haruki Kitazawa1
Dio Fico Felsidan Diatmono1, Seraphina Kumala1, Pradita Iustitia Sitaresmi2, Stefani Winda Paramita1, Megawati Andi1, Yustina Yuni Suranindyah3, Diah Tri Widayati1*
...s to determine the blood metabolite levels of Saanen-Etawah Crossbred does during the follicular and luteal phases. Fourteen non-pregnant-lactating Saanen-Etawah Crossbred does were used in this study (age 2-4 years, BCS 3, and multiparous). The same management was given throughout this research and the feed intake was observed daily. The blood was taken during the follicular and luteal phase which was validated from data of vaginal smear. The obtained serum f...
Saadatin Nurul Jannah1, Edhy Sudjarwo1, Osfar Sjofjan2*
Noura K. Al-Suwailem1, Nancy N. Kamel2, Ahmed O. Abbas1,3*, Farid S. Nassar1,3 , Dalia A.A. Elsayed4, Gouda F. Gouda1,5, Hosam M. Safaa6
... broilers on their blood metabolites, antioxidant bio-indicators, carcass yield, and meat quality. We used three hundred one-day-old Cobb chickens and were randomly divided into three groups, each with five replicates of 20 birds. The thermoneutral control group received a basal diet, while the other two groups experienced cyclic thermal stress from day 22 to 42 and were fed the basal diet provided with either 0 or 2 g MLM/kg diet. On day 42, we reported carca...
Nittaya Thongtip1, Sukanya Poolthajit1, Sirikhan Thartrak1, Qiongxian Yan2, Suntorn Wittayakun1*
...e, blood profiles, blood metabolites, and hormone concentration of growing male goats. Eight crossbred Boer (BW = 22.6 + 0.62 kg) growing male goats at approximately 12 months of age were assigned in a replicated 4x4 Latin square design. Treatments were as follows: 1) control with no supplementation (CON), 2) rumen-protected D-Aspartate (RDA), at 132.74 mg/kg body weight (BW), 3) zinc bio-complex (ZBC) at 73.74 mg/kg BW, and 4) supplementation of RDA at 132.7...
Claude Mona Airin1*, Miyayu Soneta Sofyan2, Galy Hardyta3, Khrisdiana Putri4, Pudji Astuti1
MUHAMMAD AKBAR,Arshad Javid
Siti Fatonah*, Herman and Dewi Yuni Safitri
...ontain various secondary metabolites. Therefore, these two types of plants can be used as an alternative bioherbicide for weed control. This study aims to determine the effect of aqueous extracts from fresh leaves of C. citratus, M. bracteata and a mixture of both on the germination and growth of Paspalum conjugatum and Borreria alata weeds.Treatments consisted of extracts of M. bracteata, C. citratus and a mixture of both extracts at various concentrations (0...
Mati Ullah1*, Muhammad Rizwan2, Ali Raza3, Xianlin Zhao4, Yanling Sun4, Sarah Gul5, Muhammad Ihtesham Waheed6, Muhammad Nadeem Khan7, Alvina Gul8, Sami Ullah Jan9* and Chao Huang4*
...iosynthesis of secondary metabolites pathway as the dominant one. These findings provide a broader genomic understanding of the famous probiotics bacterial species for general as well as commercial applications. This study could also be used basis for similar studies....
Umair Khatri1, Aijaz Hussain Soomro1*, Shahzor Gul Khaskheli1 and Omer Mukhtar Tarar2
...lth-beneficial bioactive metabolites. In recent years, consumers interested regarding fatty acid composition of different food are increasing. This work assessed the nutritional value of two different verities of mushrooms including Button mushroom (BM) and Oyster mushroom (OM), and determined the composition and contents of fatty acids. Mushrooms dried in cabinet dehydrator at 55°C for 16 hrs, the obtained mushroom powder packed in an airtight jar. All mu...
Bushra Irfan1, Muhammad Shahbaz1*, Asif Mukhtiar1, Muhammad Zubair Akram2, Muhammad Atif Bashir3, Sabina Asghar4, Abdul Ghaffar5 and Samreen Nazeer6*
...nd efficiency, secondary metabolites production, antioxidant machinery, and nutrient uptake in both varieties which increased growth and development as a result. So, thiourea seed priming is an effective strategy to counteract the negative effects of salt stress by improving tolerance mechanisms....
Kh. Amber1, S.G. Kotb1, W.A. Morsy2* and W. Khalifa1
...ed efficiency, and blood metabolite profile when compared to crumble and mash feed form. Supplementation of protease enzyme in diets enhanced growth performance of broiler chickens....
Noor Rahmawati*, Dea Indriani Astuti and Pingkan Aditiwati
...oduce the same secondary metabolites as their host plants. Numerous research on the bioactive elements of secondary metabolites from endophytic microorganisms, particularly endophytic fungi, have been undertaken on plants that are able to produce secondary metabolites with unique properties. When tested using the DPPH radical-scavenging assay, the secondary metabol...
Catur Suci Purwati1, Chusnul Hanim2*, Lies Mira Yusiati2, Budi Prasetyo Widyobroto3
... compound is a secondary metabolite derived from cinnamon plants. This research aimed to investigate effect of cinnamon powder on protein balance, and blood profile of etawah crossbreed goats. A total of 15 goats with an average initial body weight of 15 - 23 kg and age 8 - 12 months, were used in the study with completely randomised design (CRD) consisting of three treatments and six replications. The three treatments tested were as follows: A: without adding...
Roy Sukbir Singh1, Jekson Martiar Siahaan2,3*, Endy Juli Anto4, Syafruddin Ilyas5, Putri Eyanoer6, Hendrika Andriani7,8
...nowned for its secondary metabolites, is suggested as a potential treatment because of its hypolipidemic, antioxidant, and anti-inflammatory qualities. This study employed both in-silico and in-vivo approaches to explore these effects. The in-silico analysis involved molecular docking simulations to evaluate the interactions of Aloe vera compounds with inflammatory mediators such as TNF-α and COX-2. Furthermore, this study also employed a laboratory desi...
Muhammad Ariana Setiawan1, Ujang Hidayat Tanuwiria2*, Andi Mushawwir2
...n can be seen from their metabolite products such as total gas production, gas kinetics, and methane gas production. This study aims to determine the effect of the balance of rumen degradable protein (RDP) with non-fiber carbohydrate (NFC) in cattle rations on total gas production, gas kinetics and methane gas production in vitro. The study used an experimental method with a completely randomized design (CRD). There were six treatments of RDP balance with NFC,...
Nur Anis Hashim1, Nor Hasima Mahmod1*, Abubakar Abdullahi Lema2, Lee-Hoon Ho3 and Mohammad Moneruzzaman Khandaker1
... important antioxidative metabolites such as anthocyanins, tannins, saponins, glycosides, flavonoids and terpenoids. The findings demonstrated that fresh calyx retained the highest antioxidant capacity, thus providing insights into post-harvest processing of the calyx.
...
Moh Sofi’ul Anam1, Ali Agus1, Budi Prasetyo Widyobroto1, Gunawan2, Andriyani Astuti1*
...es, and changes in blood metabolites, which can impact their health and production. Essential trace minerals (TM), such as selenium and zinc. They support enzyme function, immune response, and antioxidant defences. Moreover, this current research assessed the impact of supplementing organic selenium and zinc on dairy cows’ blood biochemical, haematology, and total antioxidant capacity (T-AOC) during early lactation. Sixteen crossbred Friesian Holstein co...
Zainab A. Shehab1*, Assad H. Eissa2, Hind A.A. Alahmed1
...ouracil is a type of antimetabolite. A protein that helps control whether a cell lives or dies by blocking cell death called apoptosis. The gene for BCL2 is found on chromosome 18, and transfer of the BCL2 gene to a different chromosome is seen in many B-cell leukemias and lymphomas. This study aims to show the effect of 5-fluorouracil on hematological assessments (RBCs, WBCs and HB), and on bcl-2 immunoreactivity which has an important place in the apoptotic ...
Sura Saad Hamada Alkhuzaie
...rmed for all groups. The metabolites were detected using mass spectrometry (MS). The results revealed significant (p<0.05) increases in the E. coli CFUs of the NNBM group when compared with those from the SW group. These levels decreased significantly (p<0.05) in all groups, especially in the 0T group. In the case of the metabolic activity, significant (p<0.05) increases were seen in the abundance of pantothenic acid, proline, and trehalose in the gro...
Herna Febrianty Sianipar1,2,3, Wahyu Widoretno1, Luchman Hakim1, Rezi Rahmi Amolia4, Fatchiyah Fatchiyah1,2,5*
...The composition of these metabolites correlates with the health of the Tapanuli orangutan. This research aims to identify primary and secondary metabolites, such as proximates and amino acids, as well as bioactive compounds with antioxidant activity. Castanopsis argantea, Artocarpus heterophyllus, and Aglaia tomentosa fruits were tested for proximate, amino acid, phytochemical, and total flavonoid content. Liquid Chrom...
