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Influence of Varying Dietary Cation-Anion Difference on Blood Metabolites of Holstein Dairy Cows

Influence of Varying Dietary Cation-Anion Difference on Blood Metabolites of Holstein Dairy Cows

Hazem E. M. Hassanien1*, Awad M. M. Mahmoud2, Elsayed M. Abdel-Raouf1, Nabil M. Eweedah1 and Midhat. N. Nassif3

1Department of Animal Production, Faculty of Agriculture, Kafrelsheikh University, Kafr El Sheikh, Egypt.
2Animal Production Research Institute, Agriculture Research Center, Ministry of Agriculture, Giza, Egypt.
3Department of Internal Medicine, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafr El Sheikh, Egypt.
*      Corresponding author:


A negative dietary cation-anion difference (DCAD) motivates a compensated metabolic acidosis, stimulating calcium (Ca) absorption and mobilization before calving and decreasing clinical and subclinical hypocalcemia postpartum. The objective of this trial was to determine the effects of varying pre- and postpartum DCAD, mEq [(Na + K - Cl + S)]/ kg of dry matter on blood total Ca, ionized iCa, blood, and rumen metabolites, and endocrine status in prepartum and postpartum phases. Forty-eight multiparous Holstein cows range lactation 1-5 with an average body weight 706 kg ±7.29 SD were enrolled in a nested block design trial at 29 d prior anticipated parturition through 90 d in milk. A factorial arrangement of treatments -3 DCAD concentrations Tr1. (0.0, -100 or -180 mEq/kg DM) and -2 postpartum DCAD concentrations Tr2. (+250 or +350 mEq/kg DM). Prepartum urine pH was lower for cows fed -180 DCAD compared with -100 or 0.0 DCAD. Postpartum urine pH was higher for cows fed +350 mEq/kg compared with those fed +250 mEq/kg DCAD. Prepartum serum tCa, iCa, hydroxyproline (OH-PRO) was highest for -180 DCAD compared with both -100 and 0.0 DCAD. Parathyroid hormone was highest for 0.0 DCAD compared with -100, -180 DCAD. After calving there is a significant effect of tCa and iCa of prepartum treatment and we didn’t obtain any effect due to interaction between prepartum x postpartum treatment. Feeding an acidogenic diet improved Ca postpartum status.


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Pakistan Journal of Zoology


Vol. 54, Iss. 5, Pages 2003-2500


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