Adedeji A.J, Sati N.M, Pewan S.B, Ogbu K.I, Adole J.A, Lazarus D.D, Ijiwo S.J, Okpanachi A, Nwagbo I.O, Joannis, T.M and Abdu P.A
...dings include ecchymotic hemorrhages in the breast and thigh muscles, mucosa of the junction between the proventriculus and gizzard, severely enlarged and hemorrhagic bursa of Fabricius (BF) and splenomegaly. The bursa of Fabricius was harvested for laboratory investigation using AGID for infectious bursal disease virus (IBDV). As part of investigation to screen for co-infection of CIA and IBD in the flock, the BF was also screened for the presence of chicken ...
Beenish Zahid1,*, Asim Aslam2, Zafar Iqbal Chaudhry2 and Raheela Akhtar2
... control. Mild to severe hemorrhages and lymphocytic depletion, follicle necrosis, leukocytic infiltration, cyst formation and fibrous tissue proliferation at medullar region of thymus and bursa were observed. These results indicated that pathogenic field IBDV caused the serum biochemical changes by damaging the liver and kidney tissues with histopathological effect on lymphoid organs of chicken.
...
Ahmed Zein Elabdeen Mahmoud1, Muaz Magzob Abdellatif2* and Mohamed Abdelsalam Abdalla3
...were erosive stomatitis, hemorrhages in lung, liver, abomasum, small and large intestine. PPRV NP was detected in sheep (n=20) and goats (n=18), anti-PPRV NP was also detected among sheep and goats (n=162) by ELISA, 3ABC-FMD enzyme immunoassay were positive (n=6) when ovine sera were tested. The study revealed that PPR-FMD viruses were circulating in the region and warrants proper control measures.
...
Asmatullah1, Chaman Ara1,*, Shagufta Andleeb2, Maha Tahir1, Beenish Zahid1 and Madeeha Arshad1
...melia, skeletal defects, hemorrhages, displacement of limbs, open eyelids and distorted axis. Histological defects included dilation and absence of ventricles, underdeveloped cerebellum, microcardia, necrosis in atrium, underdeveloped ventricles, hydropericardium and necrosis of the liver. Skeleton analysis of cadmium treated groups showed mostly un-ossified skeletons. The control mice showed normal ossification as compared to experimental groups. Morphologica...
Mumtaz Akhtar, Iffat Naheed, Khadija Waheed* and Amna Khanum
... frequency of postpartum hemorrhage after administration of per rectal misoprostol in females undergoing normal vaginal delivery. The study was conducted at the Department of Obstetrics and Gynaecology, Teaching Hospital, Lahore from 02-09-2014 to 03-03-2015. Non-probability and purposive sampling techniques were used. A total of 220patients undergoing normal vaginal delivery at term after administration of per rectal misoprostol were enrolled with 95% confide...
Madeeha Arshad1, Asmatullah1, Chaman Ara1, Shagufta Andleeb2 and Naveed Ahmad3,*
...normalities such as skin hemorrhages, microphthalmia, limb deformities, hygromas, kyphosis, curved and short tail and fluid filled abdominal cysts. Significant increase in intrauterine growth retardation and resorptions of fetuses, with increasing dose concentration, was also observed. Morphometric observations of fetal body parts like head circumference, eye circumference, forelimb and hindlimb size and tail length demonstrated a significant (P<0.005) decr...
Madeeha Arshad, Asmatullah, Chaman Ara
Embryotoxic effects of sodium arsenate in Mus musculus
...rocephaly, hygroma, skin hemorrhages,
scoliosis and appendage deformities among arsenic treated groups were observed.
Histological studies revealed abnormalities like spina bifida, cardiac malformations,
miss-happened cochlea and oropharynx. It is concluded that sodium arsenate
causes teratogenicity in developing mice....
scoliosis and appendage deformities among arsenic treated groups were observed.
Histological studies revealed abnormalities like spina bifida, cardiac malformations,
miss-happened cochlea and oropharynx. It is concluded that sodium arsenate
causes teratogenicity in developing mice....
Kun Wang1,2, Yinglin Cui2, Xu Zhao2 and Changjiang Hu1*
...d to treat intracerebral hemorrhage (ICH) in China with good therapeutic effect. As very little is known about the mechanism of action of XN, the purpose of this project was to investigate the neuroprotective effect of XN on ICH model rats and to explore the underlying mechanisms of this therapy. In this study, experimental ICH was induced by the administration of stereotaxic collagenase type VII into the caudate nucleus. XN (at a high dose and a low dose of 3...
Aqsa Pervaiz1*, Rukhshanda Afridi1, Zahra Pervaiz1, Rabia Masood1 and Hira Pervaiz2
...osion, mucous secretion, hemorrhage, color change, slow down swimming, lake of balance, restlessness, swimming side-wise, retardation of opercular movement and quick sudden movements. The fish was anesthetized and liver were removed after 48 and 96 hours for histopathologicalstudies. The histopathological changes observed in liver were degeneration of hemopoietic tissue, destruction of hepatocytes, degeneration of bile duct, inflammatory infiltration, vacuoliz...
Ahsan Anjum1, Asim Aslam1, Raheela Akhtar1, Tahir Yaqub2, Muti-ur-Rehman Khan1, Rizwana Sultan3, Saba Usman1, Aneela Zameer Durrani4 and Muhammad Usman4*
...atory cells, congestion, hemorrhages, necrosis and other degenerative changes were observed in tissue samples of infected cattle. Significantly higher (P<0.05) micro-pathological lesion scores were given to lungs, kidney and lymph node samples from infected cattle as compared to those of non-infected ones. In conclusion, CBPP, being a major factor affecting cattle production and associated economics, warrants the implementation of control measures to mitiga...
Samia Afzal*,Sadia Zahid, Iram Amin, Muhammad Shahid and Muhammad Idrees
...of high fever, headache, hemorrhage and body rashes. Although in the past decade millions of people in several continents like Asia, Africa and some islands of Indian Ocean have faced the major outbreaks of Chikungunya virus because of its travel associated febrile nature. An inexplicable paralyzing disease has trapped thousands of people in Karachi region of Pakistan and the symptomatology among suspected cases was compatible with Chikungunya fever. Thus Chik...
Sara Zafar* and Asmatullah
... abnormalities including hemorrhages, hygromas, resorbed fetuses, deformed, hyperextended and hyperactive flexed limbs, distorted axis, and intrauterine growth retardation was found. The present study revealed that the administration of Atenolol, especially during the organo-genetic period, can cause harm to the developing embryo and Pomegranate juice significantly reduced the detrimental effects caused by atenolol.
...
Muhammad Faisal Ayoob1,2, Zaheer Ahmed Nizamani1, Asghar Ali Kamboh3, Mansoor Ayoob4, Waseem Ali Vistro3 and Abdul Sattar Baloch3*
... observed were pin point hemorrhages in proventriculus, demarcated button-like ulcers of intestinal mucosa, hemorrhages in trachea and spleen. Histopathological lesions observed in proventriculus were erosions in epithelium, localized hemorrhages and congestion in the glandular region. In small intestine of affected birds, villi appeared hyperemic and ulcerated. Tracheal surface epithelium...
Asma Chaudhary1, Qurat-ul-Ain Ahmad1, Afia Muhammad Akram1, Sadia Roshan2 and Javed Iqbal Qazi3*
...anner with symptoms like hemorrhage, swelling of the belly and anus, scale damage etc. The pathogen challenged fish were administered with Sphingomonas sp.AsCh-P3 (group-G1) and B. aerius AsCh-A7 (group-G2) treated feed in different experimental set ups. Highest Relative Percent Survival (80-90%) was recorded for fish receiving probiotic feed prior and after injection (G1b, G2b). Provision of probiotics was evident to alleviate pathogen virulence...
Saqib Nawaz1, Sher Bahadar Khan1*, Umar Sadique1, Muhammad Israr2,
Mumtaz Ali Khan3, Hameed Ullah Khan4, Muhammad Irshad5, Ihsan Ali1 and Haq Aman Ullah1
...eep were recorded having hemorrhages on serosa of intestine followed by gas filled small intestine in 41 sheep (82%), lesions in ileum and colon in 39 sheep (78%), soft kidney 27 (54%), dark congested liver 26 (52%), nephritis 23 (46%) and spleenitis 13 (26%). Microscopic lesions revealed a score of 10 of kidney tissue out of 15 while the lesion score of intestine revealed 08 out of lesion score of 15.
...
Sajid Ali1, Muhammad Avais1*, Aneela Zameer Durrani1, Kamran Ashraf2, Saira Jabeen1, Sajid Hameed3, Muhammad Awais1, Jawaria Ali Khan1 and Imtiaz Ahmad4
...white line disease, sole hemorrhage or inter-digital dermatitis. It was concluded that lameness and hoof lesions are important health problems in studied commercial dairy herds. The occurrence of lameness could be reduced in dairy herds if producers become aware of the associated risk factors, and improve management practices related to cows, environment and facility design.
...
Md. Abdullah Al Mamun1,2*, Shamima Nasren1,3, Sanjay Singh Rathore1 and Kavalagiriyanahalli Srinivasiah Ramesh1
..., pale gills, and slight hemorrhage were observed in the affected area of skin and operculum. Among the internal organs, liver lost its original reddish-brown and turned to yellowish-brown, intestinal duct remained empty and swelled. Severe infestation in catla caused eye opacity and tail rot indicated the devastating effects of A. japonicus. Infestation by this parasite resulted in histopathological changes in the skin and muscle, gill, liver, kidney, heart a...
Mohamed Lebdah1, Sahar Abd El Rahman2*, Ahmed Attia3, Reham Karam2, Naglaa Fathy Saeed Awad1, Mohamed Ibrahim El Bagoury1
... The dead embryos showed hemorrhages, congestion and dwarfism. The collected allantoic fluids were examined later by haemagglutination (HA) and haemagglutination inhibition (HAI) test. The allantoic fluids of 5 pooled samples expressed positive using specific Newcastle disease virus (NDV) antiserum. The NDV field isolates were confirmed by reverse transcription polymerase chain reaction (RT-PCR) and partial sequencing targeting F gene of amplicon size (362) bp...
Peyman Mohammadzadeh1*, Aida Rasuli2, Bahman Noroozi Gorgani2, Sajjad Mohammadi3
...of both orbits, subdural hemorrhage with edema and shifting of the mid-line to the left, frontal lobe with severe hemorrhagic discharge in the ventricles, diffuse subarachnoid hemorrhage and exclusion of berry aneurysm in vertebral arteries, traumatic tear due to intracranial and intraspinal courses, temporal were seen. Due to unilateral brain herniation, the tonsillar hernia was associated with hemo...
Bnar Shahab Hamad1, Bushra Hussain Shnawa1*, Rafal Abdulrazaq Alrawi2
... degeneration, necrosis, hemorrhage, congestion, and fibrosis. The findings revealed that the CD3 T cells were the most predominant inflammatory cell in hepatic mice tissue. Also, CD4 Helper T cells, CD8 Killer T cells, CD20 memory cells, and CD68 macrophages were detected in the infected mice. Most samples of mice expressed a different level of tissue necrosis where anti-caspase-3 was examined. Additionally, several mast cells in the mice liver samples were o...
Muhammad Izhar ul Haque1, Farhan Anwar Khan1*, Umar Sadique1, Hamayun Khan1, Zia ur Rehman1, Salman Khan1, Hayatullah Khan1,2, Faisal Ahmad1,3, Mumtazur Rahman1, Faiz Ur Rehman1, Muhammad Saeed1, Mehboob Ali1 and Saqib Nawaz1
...exhibited gross lesions (hemorrhages, edematous swelling) in 35% sheep and 27% goats. Histopathological lesions were observed in intestine and MLN in 26% and 19% sheep, and 17% and 14% goats, respectively. Additionally, PCR revealed the presence of MAP in tissue samples of 5% sheep and 3% goat. This study concluded that MAP is present in the small ruminants of district Peshawar. The infection was confirmed by PCR and iELISA. The presence of MAP could be a seri...
Mohamed M. Bahr1, Mohamed S. Amer1*, Khaled Abo-EL-Sooud2, Shaimaa M. Kamel3, Marwa A. Fouly4, Ahmed N. Abdallah5, Ashraf A. Shamaa1, Omar S. El-Tookhy1
...elopment, sub-epithelial hemorrhage and vascularization. These findings prove that EVs have the ability to heal corneal wounds even if in the peripheral parts of the cornea that are deficient in limbal stem cells. Conclusion: In terms of safety, quality, regulatory concerns, and cost, EVs are superior to corneal transplantation and live stem cell therapy.
Keywords | Mesenchymal-stem-cell, Xeno-Exosomes, corneal-ulcer, histopathology, corneal-transplant...
Sen Ye1, Jiangang Pang2 and Xiuli Wang3*
...roxaban reduces cerebral hemorrhage in mice with TPA ischemic stroke after thrombolysis. Male Wistar mice (11-week-old) as our experimental subjects were administered with warfarin (0.2 mg/kg/day), rivaroxaban (60 mg/kg/day), rivaroxaban (120 mg/kg) /day), or solvent pretreatment for 14 d to induce transient middle cerebral artery occlusion for 90 min, followed by perfusion with tPA (10 mg/kg/10ml). Infarct volume, bleeding volume, immunoglobulin G leakage and...
Rahma Boukarine*, Leila Hamdi and Kamel Khelili
... and tubular dilatation, hemorrhage, hepatocyte necrosis and glomerular degeneration, the effect of ESAE was effective in modified these damages into semi normal.To conclude, xylene administration induced hepatotoxicity and nephrotoxicity in wistar rats, while the combination of this solvent with rocket aqueous extract (Eruca sativa) attenuated this toxicity thanks to its antioxidant property....
Munir Ahmad1, Abdul Ghaffar1, Riaz Hussain2* and Rifat Ullah Khan3*
...ecimens including edema, hemorrhages, atrophy of hepatocyte and hepatocyte having eccentric nuclei. In the brain, different histological alterations like necrosis and degeneration of neurons, and microgliosis were seen, whereas the heart of treated fish showed hemorrhages, edema, and neutrophilic myocarditis. In conclusion, Pymetrozine appears to have harmful effects on blood biochemistry and histological alterations in seve...
Mohamed Mahrous Amer1*, Hanaa Sayed Fedawy2, Hoda Mohamed Mekky2, Khaled Mohamed Elbayoumi2, Ahmed Ali El-Shemy3, Mohamed Abd El-Rahman Bosila2
...with hepatic subcapsular hemorrhage mostly in S. aureus groups. Hematological parameters were mostly affected in all infected non-treated groups compared to negative control without significant difference. Histopathological changes of infected non-treated groups showed inflammation of s.c tissue with massive heterophils and mononuclear cell infiltration, hydropic degeneration of the hepatocytes and congested splenic sinusoids. While treated groups showed limit...
Khalid M. Al-Syaad1,2
...in some renal glomeruli, hemorrhage, and around edema interstitial the blood vessels. It is concluded that utilizing propolis with CC considerably reduced the biochemical and histological damage produced by CC, and it is suggested that propolis could be utilized as a cytoprotective agent against CC pathological toxicity.
Keywords | Propolis, Inflammation, Oxidative stress, Antioxidant, Cadmium chloride toxicity, Histopathology, H...
Haneen Imad Al-Sultani1*, Ahmed Obaid Hussain1, Hazar Shakir Saleh2
...s: necrosis, congestion, hemorrhage, glomerular degeneration, fatty changes, cysts and vacuoles in the renal tubule cells and lymphocytic infiltration in the kidney tissue with gradual increase in rosuvastatin concentrations 10, 20 and 40 mg/kg, respectively. Conclusion: It was concluded in the current study that the use of rosuvastatin in high doses causes nephrotoxicity. ...
Geeta Moolchandani1, Jaiperkash Moolchandani2*, Nasima Iqbal3,
Syed Mohsin Turab4, Muhammad Kashif5 and Lubna Farooq6
...sentation and antepartum hemorrhage. The aim of current study was to identify the associated risk factors which can lead to hypoxic ischemic encephalopathy. A descriptive cross-sectional study was conducted at Paediatrics Ward Unit-II of Civil Hospital, Karachi. All laboratory tests were done from the central laboratory of the civil hospital. The presence of hypoxic ischemic encephalopathy was staged using the Sarnat criteria at the time of admission. Data was...
Hongsen Xu*, Xiaoni Wang, Tie Tian, Changyu Zhao, Denghang Yu and Jun Liu
...generation and necrosis, hemorrhage and inflammatory cell infiltration, were found in diseased crayfish. In conclusion, this study confirmed the pathogen of whitish muscle disease in farmed P. clarkii, and preliminarily investigated the biological characteristic, pathogenicity and drug sensitivity of this bacterium. The results of this study will provide scientific guidance for the effective prevention and control of muscle turbidity of P. clarkii....
Ghaith Z. Hasan Al-Askari *, Eman H. Yousif Al-Taee
...ich revealed congestion, hemorrhage, and degeneration of hepatic cells. Some sections of the kidneys show vacuolation of mesangial cells in the glomerular tuft. Muscles of treated rats revealed severe histopathological changes under stress from both doses of toxic cholecalciferol, also showing the widespread mineralization of muscle fibers. From this study concluded that both doses of vitamin D can be toxic to organisms at higher levels, so they need to be use...
M.J.Al-Saadi*, Jassim E.Q.Al-Musawi
...d vessels with petechial hemorrhages and appeared pale to whitish in color. Based on the current results, it can be concluded that using dried peppermint powder in the diet of broiler chickens exposed to thermal stress has positive effects in preventing the various deleterious effects of heat stress, especially when used at a 5% mint leaves percentage. ...
Sumaira Fiaz1*, Huma Naz1*, Tanveer Ahmed2*, Iqra Zulfiqar1, Khalid Mehmood1, Muhammad Jabbar1, Syed Qaswar Ali Shah1, Muhammad Usman4
..., dilation and increased hemorrhage in sinusoids, inflammation and vacuolation in hepatocytes and ruptured hepatocytes after 60-days of experimental period. Hepatosomatic index was significantly less in Cd-treated fish than control fish throughout the experimental period. Addressing this problem requires a coordinated effort among governments, industries, and individuals to reduce heavy metal pollution, protect aquatic ecosystems, and safeguard human health.&n...
Fatima Aziz Mahdi Al-Badry
...s) in renal structure as hemorrhage, congestion, inflammation and structural disorders such as breakdown, death and absence of glomeruli with increasing of Bowman’s space. while these histological changes in liver were included congestion, hemorrhage, hypertrophy as well as necrosis of the hepatocytes. Conclusion: It was concluded in this study eating of Puma for long times causes renal-hepatic damages.
Rafiullah1, Said Sajjad Ali Shah1*, Muhammad Ilyas Khan2, Anwar Ali3, Imtiaz Ali Shah1 and Sohaib ul Hassan4
...amels revealed extensive hemorrhages in the small intestine and severe congestion of the colon and rectum. Among the hematological parameters, there was a significant reduction in hemoglobin level and hematocrit values and a significant increase in total leukocyte count, whereas all other parameters were in the normal range. Microbiological results revealed sporulated bacilli indicative of Bacillus cereus, which is an important cause of food poisoning, causing...
Hawraa F.H. Alowaid1*, Afrah Adil Hassan1, Majdy Faisal Majeed2
... inflammation, necrosis, hemorrhage, and congestion, in TML-treated animals, generally, the complementary results of the histological study, by evaluating the degree of histopathological changes, the distribution of lesions by scores (Sc) and an important factor (Fi), and the injury severity index in both kidney and liver tissue, revealed the severity of the pathological changes in the highest dose group compared with the rest of the groups. On the other hand,...
Muhammad Sajid1*, Muhammad Hamid2, Usama Ayyub2 and Muhammad Azam2
...have highlighted mention hemorrhages and extravasation involving many body organs. A deeper comprehension of the pathophysiology and immunology of the CCHFV virus will enhance patient care and hasten the creation of CCHF medication countermeasures. Physicians We anticipate that physicians should familiarize themselves with the instruments available for managing and diagnosing human CCHFV infections in human....
Hina Abrar1*, Hina Yasin1, Hira Naeem2, Rabia Bushra1, Shaukat Mahmood2 and Kaneez Fatima3
...e reflected by necrosis, hemorrhage and dilation of sinusoids, inflammation with dilation and congestion of portal vein were obvious in PHY treated group. Combination treatment of PHY with PRL showed normal liver function and identical tissue pattern as control group exhibited. It is concluded that the PRL actually reduces the blood flow to the liver consequently, supply of noxious substance is blocked. Henceforth, the PRL would provide the beneficial effects ...
Dipa Rani Pal*, Injamamul Haque Rasel, Tarun Chandra Mondal, Mohammed Lalmoddin Mollah and Shampa Rani
...erved in this study were hemorrhages on thigh and breast muscles, swollen kidneys and principal findings were in the bursa of fabricious which appeared inflamed, edematous, hyperaemic and finally hemorrhagic and atrophied. The prevalence of IBD was 13.28%, 13.33%, 19.48% and 14.30% in Banaripara, Nesarabad, Babugonj and Barishal sadar respectively. The overall mortality was 4.46%. The mortality was 4.29% in Banaripara, 4.93% in Nesarabad, 4.70% in Babugonj and...
Anas A. Humadi1*, Samer I. Sabeeh2, Ahmed Talib Yassen Aldossary3, Bushra I. Al-Kaisei2
...d by fibrosis, necrosis, hemorrhage, infiltration of inflammatory cells and liver cirrhosis in C. auris treated group compared to Syzygium aromaticum treated and C. auris infection mice. Taken together, it is clearly attributed that alcoholic extract of Syzygium aromaticum protect liver damage against C. auris potentially by increasing in catalase enzyme and lymphocyte count in treated mice. ...
Eslam Arafa1,2, Hanan M.F. Abdien1*, Mohamed Ali Zain El-Abideen3, Emad Diab2,4, Mahmoud Assad2,5, Mohamed Tarek3, Mohsen M.Z. El-Dimerdash1, Wael K. Elfeil1
... embryonic mortality and hemorrhage with congested internal organs. Survivors exhibited liver necrosis. Hepatitis, myocarditis, and infiltration of heterophilic diverse inflammatory cells were recorded upon histological examination. These findings confirm that the mutant ARV can skip maternal immunity induced by conventional vaccines due to the mismatch between vaccine strains and circulating variants. It is advisable to conduct further epidemiological researc...
