Relationship Between Infant Non-Infectious Diarrhea and Polymorphism of Lactase Gene c/t13910, Lactase Activity and Intestinal Flora Structure
Relationship Between Infant Non-Infectious Diarrhea and Polymorphism of Lactase Gene c/t13910, Lactase Activity and Intestinal Flora Structure
Ying Zhang1, Mingjian Huang1, Jianfeng Chen2, Shuyuan Wang3 and Jian Xu4*
ABSTRACT
The objective of this study was to analyze and explore the relationship between lactase activity and intestinal microflora structure in infants under 1-year old with non-infectious diarrhea. the hospital selected 60 infants in the maternal and Child Health Hospital of Haizhu District from August 2019 to September 2020 as the research objects. The infants in the experimental group were diagnosed as lactose intolerant infants, and the control group were normal infants. There were 30 cases in the experimental group and 30 cases in the control group. To understand the relationship between the 13910 gene at the upstream of lactase gene and the activity of lactase and the structure of intestinal flora in infants. there was no difference in lactase gene between the experimental group and the control group in Guangdong population. The number of beneficial bacteria in the intestinal tract of the experimental group was less than that of the control group. If the structure of intestinal flora was corrected and probiotics were increased, the lactase activity could be improved and the symptoms of lactose intolerance could be alleviated. It was concluded that when lactose intolerance occurs in infants, it is necessary to pay attention to the lack of beneficial bacteria in the intestine. Targeted supplementation of probiotics can correct the status of intestinal flora, improve the activity of lactase, and alleviate the symptoms of lactose intolerance.
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