Muhammad Sohail1,*, Muhammad Naeem Khan1, Naureen Aziz Qureshi2 and Abdul Shakoor Chaudhry3
...d out to investigate the genotoxic effect of different levels of heavy metals on gill cells of freshwater mussels (Anodonta anatina), a sentinel species in aquatic environment. Freshwater mussels were exposed to none (0µg L-1), low (120 µg L-1), medium (240 µg L-1) and high (360 µg L-1) levels of lead (Pb), chromium (Cr) and copper (Cu) alone and in combinations (Pb + Cr + Cu) for 15 days under laboratory conditions. Gill cells of musse...
Shagufta Andleeb*
Teratogenic potential of pyrethroids: a review
...a on multiple aspects of genotoxicity, carcinogenicity, mutagenicity, reproductive toxicology and neurotoxicology is available except teratogenicity. This review concludes the teratogenic potential of sublethal doses of different types of pyrethroids in various groups of animals in systematic way. On line available data interpretation through Pubmed Central NCBI, Google Scholar and Google was done to achieve the target and 122 references were found the most re...
Muhammad Muddassir Ali1,2 and İbrahim Hakkı Ciğerci1,*
...cell line in term of its genotoxicty. So, genotoxic evaluation was carried out for the alcoholic and hexane extracts of T. turcica. Methanol extracts showed the highest DNA damage (20±1) at 200 µg/ml concentration and 11.67±2.52 at 50 µg/ml. Ethanol extracts showed the 2nd highest DNA damage (19±2)at 200 µg/ml concentration and 11 ±1at 50 µg/ml. While leas...
Saleha Gul1,2, Muhammad Khisroon2, Ajmal Khan2, Attaullah1, Saira Gul3 and Gul Nabi Khan1,4,*
...unknown. We explored the genotoxic effects of tobacco smoke on peripheral lymphocytes of active and passive smokers. Blood samples were isolated from 100 males’ including 25 active-, 25 passive- and 50 non-smokers. Alkaline comet assay was done and classes were defined on the basis of comet tail length. Significant differences were found in total comet score (TCS) among different groups (p˂0.05). The TCS value of active smokers were significantly...
Huma Naz1*, Sajid Abdullah2, Khalid Abbas2, Muhammad Rizwan Tariq3, Laiba Shafique4, Ghazala Nazeer5
...la was computed. The genotoxicity of END+CPF mixture in RBCs of fish was also evaluated by comet assay. To check the genotoxicity of END+CPF mixture, blood of fish was sampled after 24-hr of intervals. Some fishes were also kept in clean water known as negative control (NC) and for positive control (PC) cyclophosphamide was injected into fish. The tolerance limits of C. catla against END+CPF was computed as 1.35&p...
Saman Muhsin Abdulkareem* and Nadir Mustafa Nanakali
...age by oxidative stress, genotoxicity effect and alteration in the expression of CYP1A1 gene, and quercetin was able to cure these damages.
...
Naveed Akhtar1*, Muhammad Fiaz Khan1*, Sadia Tabassum1,
Munawar Saleem Ahmad2 and Khan Dil Badshah3
Jabeen Farheen1,2*, Simeen Mansoor1 and Maria Abid1
...gs aimed to evaluate the genotoxic impact of widely used azo FCAs on the cell cycle by using onion as a model plant. The study was designed in a complete randomized design where the grown onion roots were exposed to 0%, 0.001%, 0.01%, 0.1%, and 1% concentration of FCA for 120 hours for macroscopic and 36 h for microscopic evaluation. The onion root tips morpho-physiology was severely affected as the concentration of FCAs increased. The macroscopic analysis man...
Abeera Razzaq1, Sajid Abdullah1, Huma Naz2*, Khalid Abbas1, Laiba Shafique3 and Qingyou Liu3
... conducted to assess the genotoxic potential of cobalt (Co) and chromium (Cr) mixture to fish Labeo rohita by using micronuclei assay. Fish were exposed to the four sub-lethal doses (26.61, 13.30, 19.98 and 7.98 mgL-1) of Cr+Cr mixture for 28 days and blood was sampled after 7 days interval. A group (n=10) of fish were also kept in clean water (negative control=NC) and cyclophasphamid (positive control=PC), separately. Blood from caudal vein ...
Sajid Abdullah1*, Huma Naz2*, Zunera Abbas1, Uzma Nazir1, Mehrunisa Basharat1, Tanveer Ahmed3, Adnan Ahmad Qazi2
...his study focused on the genotoxic effects of lead (Pb), chromium (Cr) and cadmium (Cd) on nuclear abnormalities in peripheral erythrocytes of Wallago attu were assessed by micronucleus assay. Fish were exposed to different concentrations (1/3rd, 1/4th, 1/5thand 1/7th of LC50) of Pb, Cr and Cd, separately, for three weeks. Blood sample of fish was collected to see the micronuclei (MN) and deshape nuclei (DN) in peripheral erythrocytes of fish after one-week in...
Nafisa Shoaib* and Aisha Majid Ali
...on. In the present study genotoxic effects of pesticides in the Perna viridis have been evaluated by the induction of micronuclei (MN). The aim of the present study was to assess the MN frequency in the haemolymph of green mussel (Perna viridis) after exposure to different concentrations of organophosphate pesticides (chlorpyrifos, malathion), synthetic pyrethroid pesticide (cypermethrin, lambda-cyhalothrin) and herbicide (buctril). Haemocytes of bivalve play ...
Ahlam G. Khalifa1*, Walaa A. Moselhy1, Hanaa M. Mohammed2 and Khaled Abdou1
..., Safety ...
Dalia M. Aboelhassan1*, Inas S. Ghaly1, Noha E. Ibrahim2, Nermeen M. Shaffie3, Mariam G. Eshak1, Aboelfetoh M. Abdallah4, Ibrahim M. Farag1
...his component has potent genotoxicity, causing various disorders to human and animal health. Hence, the present work is designed to investigate the capacity of Fagonia cretica extract (FCE) to inhibit bisphenol A-induced genotoxicity and histopathology in rats. In the genetic study, the assaying of expressions of IkBα and COX-1 genes in liver tissues, as well as the expressions of mdr1a and COX-1 genes in kidney tissue...
Reem M. Ramadan1, Fady Sayed Youssef2, Gehad Genidy Mohamed3, Sameh Hamed Ismail4, M.M. El-Bahy1, Shimaa Abdel-Radi1*
...nd the degree of the DNA genotoxic damage as represented by variations in the tail length (μm), percent of DNA in the tail segment, and tail moment (μm). Postmortem (PM) inspection of birds inoculated by LC90 exposed sporulated oocysts demonstrated a very slight or un-apparent reddens without thickening in the cecal wall with close relation to the normal un-infected control group. This with in contrast to the group inoculated by LC50 exposed sporulated o...
Aamir Mushtaq1*, Fatima Habib2, Umar Farooq Gohar3, Abdul Malik4 and Mobasher Ahmad2
...ore its fetotoxicity and genotoxicity.
Novelty Statement | In this article, we contributed a new thing by providing scientific evidences regarding acute and chronic toxicity of Pimpinella anisum that P. anisum is free from the toxic. It can be used in food and medicines quite safely.
...
Ali I. Al-Ameedi1, Zahraa M. Ayad2*, Wed Abbas Mohammed3, Salim K. Hajwal4
... to be attributed to the genotoxic effect of the drug. On the other hand, a significant decrease (P>0.05) in the mean of chromosomal aberration in both groups (T2 and T3) that pretreated with GB extract and omega3 respectively. HU treatment caused serious CAs formations such as dicentric chromosome, Acentric, deletion, ring, and a high rate of breaks in bone marrow cells. As a results, GbE would be good candidates for administration as a supplement to decre...
Ghusoon Hasan Jadaan1*, Khalisa K. Khudair2
... cause cytotoxicity and genotoxicity in a variety of cell lines due to oxidative stress. Curcumin Phytosome has antioxidant effects. We aimed to determine how silicon dioxide nanoparticle (SiO2NPs) exposure to female rats affected the oxidative state. Ultraviolet-visible (UV-VIS), scanning electron microscopy (SEM), and Fourier transform infrared (FTIR) spectroscopy were used to investigate SiO2NPs and Curcumin Phytosome nanoparticles (CPNPs). Intense surface...
Aniqa Qaisar, Shabana Naz* and Sajida Arooj
... metal contamination and genotoxicants....
Huma Naz1*, Sajid Abdullah2, Tanveer Ahmed3*, Khalid Abbas2, Syed Qaswar Ali Shah1, Muhammad Rizwan1, Fareeha Latif4, Adnan Ahmad Qazi1, Muhammad Adeel Hassan5
...onducted to find out the genotoxic effect of insecticides on DNA damage and nuclear anomalies in RBCs of Labeo rohita after exposure to chlorpyrifos+endosulfan (CPF+END) by using Comet and Micronucleus Assay. Twenty fingerlings of L. rohita was kept in LC50 concentration of CPF+END, (1.95±0.02 μgL-1 for 96 h) for 5 days after acclimatization. The blood sample of 5 fish was collected after 24, 48, 72 and 96 h to see the DNA damage and nuclear anomalie...
Abdul Ghaffar1*, Ayesha Maqsood1, Riaz Hussain2, Ghulam Abbas3, Rabia Tahir4, Habiba Jamil1, Fozia Afzal5, Ahrar Khan6,7, Muhammad Ahmad Chishti1, Shahnaz Rashid3, Aliya Noreen8, Kashfa Akram1 and Maria Niaz1
...ogical, biochemical, and genotoxic potential in rural inhabitants exposed to pesticides. Samples were collected across different age groups and compared with those from 100 unexposed individuals. Demographic characteristics of the pesticide-exposed workers in the district were also observed. Hematological and biochemical parameters, including WBCs, RBCs, hemoglobin, HCT, MCHC, MCH, lymphocytes, MCV, neutrophils, monocytes, eosinophils, potassium, sodium, calci...
