Kathryne E. Taylor1 and Karen L. Mossman1,2*
... block the activation of antiviral signaling have revealed a potential explanation for some of this confusion – namely, that ICP0 has important functions in the cytoplasm that have been generally disregarded, due to the fact that many frequently used experimental manipulations restrict this protein to the nucleus. This commentary discusses the significance of these findings to the ICP0 field....
Paulo Eduardo Brandao
...o the lack of success of antivirals in inhibiting rabies virus intracellular cycle both in vitro and in vivo, and the high failure rate of this treatment in human patients, the use of RNA interference (RNAi) for Post-transcriptional Gene Silencing (PTGS) has witnessed an increasing interest from those concerned with a cure for rabies, inspired on the success obtained for other viral diseases. This review is intended to present the current situation of RNAi aga...
Hu Zenglei1 and Xiufan Liu1, 2*
...duces more potent innate antiviral and inflammatory response, and causes more severe damages in lymphoid tissues when compared with virulent viruses of other genotypes. Therefore, severe pathology in immune organs, caused by genotype VIId of NDV, is associated with high levels of virus replication and an intense innate immune response....
Shen Yang1, Guang-Zhi Tong1, 2*
Huaichang Sun
...the current situation of antiviral roles of amiRNAs, against variable RNA viruses in particular....
Yongfeng Li, Mo Zhou, Xiao Wang, Libao Xie, Hua-Ji Qiu*
...fficiently screening the antivirals against CSFV and viral receptors, conveniently tracking the viral proteins in live cells as well as improving diagnostic methods and vaccines for classical swine fever....
Behzad Hussain1, 2, Abdullah Iqbal2, Muhammad Abubakar2*
... currently but Ribavirin antiviral drug is used to cure this disease. There is currently no commercially available vaccine for this disease. It is recommended that the disease can be controlled by adopting preventive measures such as avoiding of tick bites and contact with blood of the suspected animal. ...
Taghreed A. Hafiz1, Murad A. Mubaraki1*, Mohamed A. Dkhil2,3 and Saleh Al-Quraishy2
Waqar Islam*1, 2, Madiha Zaynab3, Muhammad Qasim2 and Zujian Wu1,2
...volved in triggering the antiviral resistance in plants. Antiviral RNA silencing, R-gene mediated resistance and host factor related recessive resistance are categorized as most beneficial plant defense approaches used by plants. The review also briefly explains about introgression of durable resistance to generate virus resistant cultivars for economically important crops through molecular breeding techniques via utilizing ...
Mohsan Ullah Goraya1,2, Liaqat Ali1,2 and Iqra Younis3
...g to establishment of an antiviral state of the host. In this review, we discuss the recent understanding in host responses to avian viral infection and their impact in health and disease. ...
Muhammad Hidayat Rasool*, Abuzar Muhammad Afzal*, Abu Baker Siddique*, Waseem Akram**, Muhammad Saqalein*, Madiha Basit* and Muhammad Farooq Tahir***
ANTIVIRAL ACTIVITY OF VIRO CARE GZ-08 AGAINST NEWCASTLE DISEASE VIRUS IN POULTRY AND ITS IN-VITRO CYTOTOXICITY ASSAY
...been exploited to obtain antiviral compounds in several latest studies. In this study, the antiviral activity of Viro Care GZ-08™ was checked up invitro, in-ovo and in-vivo. The cytotoxicity assay of the product was performed using Vero cell line. All the trials revealed that the stock solution and 1:2 dilution of GZ-08™ had some antiviral activity as well as were cytotoxic. As...
Muhammad Shahbaz Aslam1, Iram Gull1, Zaigham Abbas2,* and Muhammad Amin Athar1
...pe of cytokine with both antiviral and anticancer activities. Binding of IFNα-2 to its receptor on cell surface leads to activation of interferon stimulated genes which mediate its anti-proliferative and anti-angiogenic properties. Similarly, Thymosin alpha 1 (Tα-1) helps to fight against different infections such as cancer and hepatitis with its immune modulating properties as well as through its direct action on target cells. The recombinant expr...
Kiran Aqil1, Muti-ur-Rehman Khan2, Asim Aslam2, Aqeel Javeed5, Rizwan Qayyum1, Farooq Yousaf,1 Farkhanda Yasmeen1, Muhammad Luqman Sohail3 and Sajid Umar4,*
...osses. In current study, antiviral activity of six dilutions of Nigella sativa (N. sativa)alcoholic extracts against the PPRV was investigated in vitro. Vero cell lines infected with PPRV were treated with six dilutions alcoholic extracts of N. sativa (200, 100, 50, 25, 12.5 and 6.25 µg/mL). The antiviral effects were judged by 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di-phenytetrazoliumromide colorim...
Mirza Imran Shahzad1, Hina Ashraf2,*, Muhammad Arshad3, Sabeeha Parveen4, Amna Aslam4, Nargis Naz4, Zahid Kamran1, Sumbul Gohar Khalid5, Sajid Hameed1, Muhammad Ashfaq6 and Muhammad Mukhtar7
...s based on evaluation of antiviral potential of methanolic extracts of eleven selected Cholistani plants against New Castle Disease Virus (NDV)-LaSota strain. All of these plants were reported for their different pharmacological activities but their antiviral potentials were not known before. The methanolic extracts were made and concentrated by rotary evaporator and finally dissolved in distilled water before taking their <...
SiRui Wang1,2, Fekede Regasa Joka1,2, XiaoLong Wang1,2,* and SuYing Bai2,*
... gene has broad-spectrum antiviral effects. This gene is particularly important for the prevention and treatment of avian influenza. Currently, this gene is more studied in poultry, and studies in wild birds are rare. To understand the antiviral site of the Myxovirus-resistance (Mx) protein in the evolution of different wild birds, 10 wild bird species, including Anas formosa, Anas crecca, Anas strepera,...
Fan Yi1,2, Xiaobin Yang1, Shigen Ye1, Hua Li1 and Ruijun Li1,*
...an and livestock for its antiviral and antibacterial activities. In this study we are investigating the effect of HCT in aquaculture animals. In this study, 300 olive flounders (Paralichthys olivaceus) were stochastically divided into four experimental groups: basal diet feeding group, 0.5% HCT continuous feeding group, 1% HCT feeding group, and 1% HCT interval feeding group. Three replicates were set for each treatment, and 25 fish were stocked on each...
Mehboob Arslan* and Xin Yang
...ug development of future antiviral therapeutics. In fact, metabolism is considered as a crucial player in the cascade of viral interactions, its modulation is essential to decide the final outcome of viral infection. Here, we concisely present how viruses alter the metabolic pathways for their own survival. ...
Shaikh Abdul Lateef, Zhou Lin, Wu Jian, Junjie Qian, Jonathan Hartanto Tan and Zheng Shusen*
...ed with HBV. The current antiviral therapeutics are not providing adequate protection against HBV. It is mandatory to characterize and devise novel antiviral therapies to control the spread of hepatitis ...
Olotu Titilayo Mabel*, Adeosun Idowu Jesulayomi, Kaka Mary Oluwatosin and Oladipo Elijah Kolawole
... with each other and its antiviral drug susceptibility which will provide more information on its sensitivity and resistivity to each antiviral drug. Seventeen partial genome sequences of HIV-1 Pol gene from some West African countries were retrieved from NCBI database. Evolutionary relationship was determined by Multiple sequence alignment using Clusta W and the sequences were further analyzed using MEGA 6 for phylogenetic ...
Joseph Anejo-Okopi1*, Ocheme Julius Okojokwu1 and Onyemocho Audu2
...f effective pangenotypic antiviral DAAs. Understanding the extent of HCV genetic diversity is important for treatment and development of vaccine. Among the routes of HCV transmission; intravenous drug addiction or injection drug use accounts for the majority of many cases apart from hemodialysis patients, unprotected sexual intercourse, blood transfusion and vertical transmission. Therefore, there is a need for government commitment for HCV elimination program...
Sumaira, Ali Mujtaba Shah*, Ghulam Asghar Solangi, Ifra Anwar, Qudratullah Kalwar
...eficial effects, such as antiviral, antibacterial, anti-diabetic, anti-carcinogenic and anti-ageing. Besides, camel milk contains abundant proteins which are conductive to improve the immunity functions. Thus, it is necessary to illuminate the beneficial impact of camel milk and its composition.
Saba Afzal1, Sohail Raza1,*, Masood Rabbani1, Sehrish Firyal2, Imran Altaf1 and Zahra Naeem1
...as conducted to find the antiviral potential of ivermectin against Peste des Petits Ruminants Virus (PPRV) in vitro. Firstly, cell cytotoxicity of ivermectin in the Vero cells was determined using MTT assay. The antiviral activity of ivermectin was determined using viral inhibition assays and median tissue culture infectious dose (TCID50). The results showed that 2.5 µM concentration of the ivermectin...
Asmaa A.M. Abd El-Ghani *; Ahmed B.M.; Abdel-Raouf A. ; Nagwa S. Ata* and H.A. Hussein
...div>BHV-1.
...
Sallam A.A.A.1, Hoda M.A.Waziri2,E. K .F. Elbeshehy1, SamiaI.Massoud,1 and Abeer M. Abo El-Wafa2.
...GE) and onion (OE) as an antiviral against BBMV infection in vivo has been
evaluated. The percentage of virus inhibition induced by GE and OE varied according
to the time of treatment (1, 2 and 3 days).GE was more effective in reducing the
percentage of infection produced by BBMV on faba bean plantsthan did OE.
...
Hanaa H. A. Gomaa1; Entsar A. A. Nassar2; K. A. El-Dougdoug3
...f milk thistle that have antiviral activity with different degrees, line 32 with (HAV), line 9 with (COXB4) and, line 28 with (HSV1)....
Samah A. Mokbel, Soad H. Taha, Mahmoud M. Abd-El Hamid, Ali H. Hamed
...ations. Also, results of antiviral activity of lactoferrin at concentration 1000 mg/L showed great potential as phytotherapeutic source to produce quality and health plantlets for rapid and large scale in vitro production....
M. A. Kararah1, Om-Hashem M. El-Banna1, Salwa N. Zein2 and Abd-Elrehiem, A.F.3
...
oil was used as an antiviral agent to reduce PMV infection. Parahydroxy
benzoic acid was effective at 0.001% concentration, exhibited 88.7%
reduction when had applied 2h before inoculation. Also, salicylic acid was
effective as it reduced infection to 77.4% at 0.01% concentration when
applied 3h before inoculation. Whereas camphor oil exhibited lesser
reduction being (74.6) when used at 0.001% c...
Manal A. El-Shazly1. M. I .Kobeasy2and Sarah H . Altalhi3
...major leaves was used as antiviral to reduce the infection with TSWV at three concentrations levels (500,1000 and 2000 μg/ml and 50,125,250 μg/ml, respectively).Viral infection was reduced by using the highest concentration of Basil essential oil and ethanolic extract reached to 45.99% and 63.82%, respectively. Different treatments with antiviral compounds decreased the content of total soluble sugars, titrable acidity...
Dina N. Abd-Elshafy
...>Aim: To study potential antiviral effect of methanolic extract prepared from green tea on
HAV and explore supplementing drinking water in endemic areas for the virus with such an
extract to control infection.
Methods: Green tea powder was used for methanolic extraction. Cytotoxicity assay was
carried out according to Aquino (1989) to identify non-cyotoxic concentrations of the
prepared extract. Plaqu...
Coronavirus Disease (COVID-19) with Special Reference to Pakistan: A Review on its Different Aspects
Sahar Mubashar*, Tariq Mukhtar and Nasir Ahmad Khan
... the most reliable. Some antiviral drugs have shown to be effective against the virus like Favilavir, Remdesivir, Chloroquine, hydroxy-chloroquine, Tocilizumab etc. but further clinical studies are required to confirm their efficacy. In Pakistan, blood plasma therapy is in high demand but involves the risk of transmission of blood borne pathogens. As Pakistan lacks medical facilities. the government has to get testing kits and primers from other countries. Onl...
Alexander Tsybulsky1*, Tatyana Tabakaeva1, Anna Klimovich2, Michail Shchelkanov1, Eduard Kostetsky1, Maksim Aliev1, Anton Degtyarenko3
...nnate immune factors for antivirals evaluation, interferon system (IFN) in particular, molecular guard factors for cell genome integrity evaluation (p53, etc.). Methods. In domestic cats with a previously established diagnosis of «FeLV-infection and chronic leukaemia» (n = 10) and healthy control cats (n = 6), we examined the following: 1) Haematological parameters of the blood; 2) Biochemical blood indicators of the physiological characteristics o...
Sana Shakoor, Tahir Rehman Samiullah, Naila Shahid, Abdul Qayyum Rao*, Aneela Yasmeen, Sana Tahir, Ayesha Latif, Saira Azam, Ahmad Ali Shahid and Tayyab Husnain
... last few years. Besides antiviral treatment development of an effective vaccine to combat a high mortality rate is the need of time. As a step towards the development of the vaccine for the H9N2 strain of avian influenza virus HA gene was chosen as the immunogenic antigen because it is highly conserved among H9N2 strain of avian influenza virus. Moreover, immunogenic regions within HA gene may contain potential immunogenic epitopes. The specificity of HA prot...
Noora Hassan Hezam Al-Aqmer1*, Zain Aamir2, Muhammad Farooq Hanif3, Soumble Zulfiqar4, Sibgha Zulfiqar1, Mateen Izhar5 and Abdul Rauf Shakoori4*
...atitis C directly acting antiviral treatment. This study which is a case control study included 66 hepatitis C patients (genotype 3) who responded to the directly acting antiviral treatment and achieved negative HCV-RNA three months after completing the treatment (sustained virologic response (SVR)) and 66 hepatitis C patients (genotype 3) who did not achieve SVR three months after completing the same treatment. Informed con...
Tri Untari1*, Sitarina Widyarini2, Michael Haryadi Wibowo1, Marla Anggita1
...en reported to harbor an antiviral effect on Newcastle disease virus (NDV) infection in ovo. This study was aimed to evaluate the activity of red ginger powder, ethanolic extract, and essential oil as immunostimulant agent during NDV challenge in vivo. Chickens were divided into seven groups of different treatment regimens. Group I - IV were vaccinated NDV while group V-VII were unvaccinated. Each group was treated with either red ginger powder (group I and V)...
Muhammad Musa1*, Saba Saeed2, Azher Mustafa2, Muhammad Ussama Yasin2, Saima Naseer2 and Iftikhar Haider3
Aiman Al-Mufarji1, Abd El-Nasser Ahmed Mohammed1*, Haitham Al-Masruri2, Rashid Al-Zeidi3
...mpound as antibacterial, antiviral, antioxidant and anti-tumour have been well established. The valuable chemical constituents of microalgae include “proteins, polysaccharides, lipids, PUFAs, vitamins, pigments and other bioactive compounds”. The microalgae composition varies depending on species and nutrient availability for production. Genetic engineering might be used for production invaluable microalgae compounds. Microalgae consider a promisin...
Sahar M. Saber1*, Ahmed M. A. Albehwar2, Amani M. Abas3, Omaima A.A. Alshamandy2, Noha A. El said4 and Marwa Y. Hamad4
...epare a natural economic antiviral agent against Rift Valley Fever virus which may be able to minimize the virus infection. This study was designed as a preliminary in vitro investigation of the effect of interferon-induced by bovine ephemeral fever virus (BEFV) in Madin-Darby Bovine Kidney (MDBK) and African green monkey kidney (Vero) cell cultures against RVFV. Such interferon was successfully obtained with high concentrations by both cell cultures up to a d...
Monu Karki, Amit Kumar and Gnanavel Venkatesan*
...erapy, immunomodulators, antivirals, viral vectors, and recombinant vaccines....
Ubaida Hussain1,2*, Amtul Jamil Sami1*, Shazia Rafique3*, Muhammad Idrees khan3 and Ahmad Ali Shahid3
...f neem seeds have strong antiviral potential against HCV without having any significant cytotoxic effects....
El-Dougdoug2, Kh.A; Ghalyl, M.F. and Tahal , M.A.
...text-align: justify;">An antiviral producing• Streptomyces species were isolated from soil rhizosphere in Zagazig province of Egypt. In order to identi$r the Streptomyces strains, morphological, physiological, biochemical and antagonism testes were performed. The Egyptian isolates of Streptomyces were found to be a species ofcalvus, canarius, vinaceusdrappus, nogalater and viridosporus. The Streptomyces spp were grown in glycerol asparagine broth medium a...
Mahdyl , A.M.M.; Hafezl , M.A.; EL-Dougdoug2, Kh. A.; Fawzyl , R.N. and Shahwanl , Eman S.M.•
...m inerme and Kombucha as antiviral to control the virus infection and detection systemic acquired resistance (SAR) Were Studied. SAR was detected by determination of salicylic acid (SA) resulted induction of protein related to biotic inducers, virus concentration and disease severity (DS). The obtained results from quantification of total SA in induced tomato plants (after 7 days of spraying inducers) showed high level of SA with kombucha &eatment followed...
Muhammad Akram1, Anirban Mandal2*, Mehwish Iqbal3, Arindam Mukherjee4, Ritika Bandyopadhyay5, Surendar Rangasamy6, Rida Zainab1, Muhammad Talha Khalil1, Pragnesh Parmar7 and Umme Laila1
...es and constituents with antiviral activity exists in numerous plants, for instance, rutin, a flavonoid glycoside generally found in a range of botanicals, is efficient against herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), and influenza A virus. Ascorbic acid, beta carotene and lots of phenolics play active parts in decreasing inflammation, postponing aging, and averting certain kinds of carcinomas. There are some phenolic compounds...
Yasameen Waleed Al-Abedi1, Murtadha Kadhim Hasan2*, Alaa Abdalhadi Halboti3, Ali Abdulhussein Saleh Alsaeedi3, Rafed Abbas Kadhum1
...trating applicability of antiviral system (Clustered regularly interspaced palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins (CRISPR-Cas) for carrying out site-specific epigenetic alterations and so uncovering the capability of its use for the upcoming revolution of genetic engineering. The study provides an outline of the CRISPR-Cas system, followed by the mechanisms of genome modification, mainly focusing on the repair mechanisms of the doubl...
Muhammad Sajid1*, Muhammad Hamid2, Usama Ayyub2 and Muhammad Azam2
...ng, and diagnostics, and antiviral treatment of CCHF, we provide a critical reviewed of the literature. The chemical interactions and life cycle of viruses are intricate and are poorly understood. Despite our limited understanding of pathogenesis and immunobiology, multiple routes contribute to the viral entry, replication, and clinical damage. A few autopsy reports have highlighted mention hemorrhages and extravasation involving many body organs. A deeper com...
Nasr Tarq Mohammed
...tibacterial, antifungal, antiviral, and immune-boosting properties. This study aimed to evaluate the anticancer potential of aqueous garlic extract (AGE) against breast cancer cell lines. The use of a simple aqueous extract allows for easy and cost-effective preparation while retaining bioactivity. In this research, the effectiveness of AGE in inhibiting cancer cell viability was assessed using cancer cell lines CAL51 and AMN3. The cell lines were treated with...
Saima Younas and Aleena Sumrin*
...e based on direct acting antivirals (DAAs), despite high efficacy of antivirals, still therapy failure has been reported in 5-10% cases due to resistance mutations of amino acids. This study was aimed to analyze clinically important resistance associated mutations (RAMs) to daclatasvir (DCV) in HCV GT-3a NS5A region in treatment naive and DAA treatment experienced patients, to understand their role in treatment failure. Pati...
King Hei Ip
...nderstanding towards bat antiviral innate immunity. By completing the genetic annotation of bats, developing wild-like environments when studying the bat immune system, improving data collection methods and conducting further studies on bat immunity and viral co-infection would further the understanding on infection dynamics and control as well as the relationship between bats and viruses, allowing a better prevention of future pandemics through a more underst...
Hosts and Viruses
December
Featuring
-
Current Understanding and Future Perspective of Bats Antiviral Innate Immunity
King Hei Ip
Hosts and Viruses, Vol.12, Pages 01-38
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