RNAi-Based Treatment for Rabies: Current Achievements and Insights Towards a Cure
RNAi-Based Treatment for Rabies: Current Achievements and Insights Towards a Cure
Paulo Eduardo Brandao
ABSTRACT
Due to the lack of success of antivirals in inhibiting rabies virus intracellular cycle both in vitro and in vivo, and the high failure rate of this treatment in human patients, the use of RNA interference (RNAi) for Post-transcriptional Gene Silencing (PTGS) has witnessed an increasing interest from those concerned with a cure for rabies, inspired on the success obtained for other viral diseases. This review is intended to present the current situation of RNAi against rabies, as well as insights into the future on the field.
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February 2015
Vol. 2, Iss. 1 Pages 1-14
