Salvadora persica as natural anti-viral agent
Salvadora persica as natural anti-viral agent
Asmaa A.M. Abd El-Ghani *; Ahmed B.M.; Abdel-Raouf A. ; Nagwa S. Ata* and H.A. Hussein
ABSTRACT
The antiviral and cytotoxic activity of etanolic extract of Salvadora persica(L.)
roots was investigated on bovine herpes-1 (BHV-1) infection in vitro. An ethanolic
extract of Salvadora persica was used in two concentrations. MDBK cells grown on
Minimum Essential Medium (MEM) were used for virus propagation and titration. The
effects of two concentrations of Salvadora persica on viral growth in MDBK cells as
well as cytolytic activity of BHV-1 were evaluated at different times pretreatment
,simultaneouslly and after adsorption. The results demonstrated that the safest
concentration (non-cytotoxic) of the plant extract under study on MDBK cells was 0.1
mg/ml.The plan extract showed a significant antiviral effect against BHV-1 at
simultaneous treatment experiment. The virus titeration assay showed a marked decrease
from 105 TCID50/ml to 103 TCID50/ml in adsorption step simultaneouslly incubated
with Salvadora persica extract . In contrast, the plan extract didn’t show any activity
against BHV-1 neither in pre- nor post- treatment experiments. Indeed, the present study
confirms that ethanolic extract of Salvadora persica roots had an antiviral effect against
BHV-1.
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December 2013
Vol. 10, Pages 1-171
