Antiviral Diversity of Compounds Derived From Silybum marianum
Antiviral Diversity of Compounds Derived From Silybum marianum
Hanaa H. A. Gomaa1; Entsar A. A. Nassar2; K. A. El-Dougdoug3
ABSTRACT
Six genotypes of purple and white head flower varieties and one parent type of milk thistle (Silybum marianum L.) grow in the Egyptian desert. These are important plants used for treatment of various liver diseases. All the studied genetic parameters showed variations among milk thistle and parent varieties (plant height, main branch, total branches, head flower, fruit yield per plant). Concentration and yield amount of seven detected silymarin compounds using HPLC showed wide variations among varieties. They ranged from 9.2 to 34.78 mg/g fruits or 450.25 to 1250.25 mg/plant. The silymarin production has the same pattern of fruits yield. The methanolic solutions were extracted from milk thistle varieties then evaluated against HAV, HSV1 and COXB4 viruses. The cytotoxicity of different milk thistle methanolic extracts in Vero cells did not show any morphological difference compared with control. Antiviral affects of milk the most potent methanolic solutions of milk thistle that have antiviral activity with different degrees, line 32 with (HAV), line 9 with (COXB4) and, line 28 with (HSV1).
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