Misbah Riaz1, Qaiser Mansoor2, Maleeha Akram1, Muhammad Ismail2, Parveen Akhtar3, Shakeel Mirza4, Mazhar Qayyum1, Afzaal Ahmed Naseem1, Faheem Tahir5 and Syed Shakeel Raza Rizvi1*
...rized by low FSH, LH and testosterone (T) and absent or impaired sexual development at puberty. Amongst others, mutations in GPR54 and GnRH receptor (GNRHR) are possible causes of HH. This study aimed at identification of mutations in GPR54 and GNRHR genes and their correlation with HH in Pakistani boys. Thirty one boys with delayed puberty and thirty one normal age matched controls were examined. Genomic DNA was extracted and amplified by PCR using specific p...
Afzaal Ahmad Naseem1*, Maleeha Akram1, Sarwat Jahan2, Kiran Afshan2, Zubaria Iqbal1, Faheem Tahir3, Mazhar Qayyum1 and Syed Shakeel Raza Rizvi1
... growth hormone (GH) and testosterone (T). GH and T affect linear growth velocity (LGV) directly through stimulation of chondrocytes and osteoblasts. Furthermore, T promotes LGV through augmentation of GH secretion. Nevertheless, age and developmental stage dependent changes in GH and T and LGV and their associations require further investigation. This study examined relationships between GH and LGV, T and LGV and GH and T in 540 normal healthy boys of 1 to 20...
Kadir Karakuş1, Bahat Comba2, Abuzer Taş3, Tunahan Sancak3, Arzu Comba2, Devrim Saripinar Aksu4, Hasan Koyun5 and Mohammad Masood Tariq6,*
...o be significant only in testosterone (P <0.05). No significant difference between the control and surgical groups in testosterone was noted. In this study, although the application of different castration methods in 4-month-old male Norduz sheep resulted in changes in the blood hormone levels, it was determined that these changes did not affect body weight. In conclusion, the evaluation of the process in castrated six-mo...
Shafaq Fatima*, Sumrin Sahar and Khalid Lone
... of sex steroids such as testosterone (T), 11-ketotestosterone (11-KT), estradiol-17β (E2), cortisol (C), progesterone (P) and 17α-hydroxyprogesterone (17α-HP) during annual reproductive cycle under semi-arid climate conditions. GSI increased during March concomitant with gradual increase in levels of T, P and 17α-HP. Highest values of these parameters were observed at different stages of go...
A.M. Abdul Azeem, A.N. El Shahat* and Ashraf M. Mounir
... stimulating hormone and testosterone in addition to marked improvement in the level of total antioxidant capacity and glutathione content and the activity of superoxide dismutase activity and catalase activity of the liver and testes of lead-intoxicated rats. In conclusion GPE could ameliorate the damage and apoptotic effects occurred by exposure to toxic dose of lead.
...
Naimat Ullah1, Sarzamin Khan2, Muhammad Mobashar3, Shahbaz Javaid4*, Tarique Tonio1 and Asif Mahmood5
... increase (P<0.05) in testosterone level. However, level of glucose (mmol/lit) and blood urea nitrogen (mg/lit) and triglycerides (mg/lit) were found significantly lower. Therefore it is concluded from the present study that dietary supplementation of fat to crossbred bulls during hot summer tropical conditions can reduce the influence of heat stress on reproductive performance and thus enhances the semen quality.
...
Derya Kocamaz* and Elif Oruc
..., catalase and estradiol/testosterone levels decreased, while the amount of etoxyresorufin-O-deetylase (EROD), superoxide dismutase (SOD), glutathione S-transferase (GST), glutathione (GSH) and protein carbonil (PCO) increased in comparison to the control. After the recovery period, EROD, GST, malondialdehyde, estradiol/testosterone levels were found to be lower than the control. In the pesticide mixture group, the activity ...
Yan-Guo Han, Jia-Yuan Wu, Ri-Su Na, Wei-Jiang Si, Yu-Qin Han, Yan Zeng, Yong-Ju Zhao and Yong-Fu Huang*
...isspeptin antibodies and testosterone by indirect enzyme-linked immunosorbent assay. Scrotal circumference was detected from week 0 to week 14 after primary immunisation, and the testes were weighed at week 14 after primary immunisation after slaughter. The concentrations of 4-methyloctanoic acid and 4-methylnonanoic acid in waist subcutaneous adipose tissue were detected using gas chromatography. Immunisation of oral and plasmid-injected KISS1 DNA vacc...
Shakeel Ahmed* and Sarwat Jahan
...MS administration plasma testosterone (T) and growth hormone (GH) levels were determined in four normally fed and 48 hours fasted adult male rhesus monkeys.Fifty nmol (50 nmol)of NMS was injected through a cannula affixed in saphenous vein. Blood samples were collected individually 60 minutes before and 120 minutes after NMS administration at 15 minutes intervals. Plasma T and GH concentrations were determined by using specific Enzyme Immunoassay (EIA) kits. 4...
Faiqah Ramzan1,2,*, Irfan Zia Qureshi2 and Muhammad Haris Ramzan3
...presses gonadotropin and testosterone release and spermatogenesis. Intraperitoneal kisspeptin administration was carried out in 05 weeks old prepubertal male Sprague Dawley rats, twice daily for 12 days, at three different dosage regimens: 10ρg, 1ηg and 1µg compared to control (saline-treated) rats. Effects on pituitary gonadotropins [Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH)], secretion of testoster...
Eman A. Al-Shahari1,2, Abdelhalim A. Alkhazendar3, Eman R. ElBealy4 and Abeer A. Alm-Eldeen3*
...xide dismutase activity, testosterone level and sperm count and viability. Seminiferous tubules diameters were 84.3 ± 5.6 µm and their epithelium heights were 21.2 ± 3.4 µm. Only spermatogonia that were positively reacted with proliferating cell nuclear antigen (PCNA). After quercetin administration, they showed an improvement in the previous biochemical parameters. Seminiferous tubule diameters were 105.2 ± 2.1 µm and th...
Hagar E. Mohammed1, Ranwa A. Elrayess2 and Heba N. Gad El-Hak2*
...s and a decline in serum testosterone levels which may have a bad impact on male infertility, on the other side, treatment the rats with the combined extract of different doses of A. monosperma or M. piperita attenuated the deleterious damage to the testes, the sperm index and the sex hormones. This study indicated that the traditional use of these two herbs as a mixture has no effects on male reproductive health.
...
Zafer Karslı1,*, Dilek Şahin1, Meryem Öz2, Ünal Öz2 and Orhan Aral2
...ormones (17α-Methyltestosterone (Mt), 17β-Estradiol (Es) at three different doses (20, 40, 60 mg kg-1) and control feed was without hormone. All six experiment groups receiving experimental diets and control were conducted in 3 replicates in 21 aquariums for 3 months in the first experiment. L. caeruleus were fed orally with these hormone-supplemented feeds and growth parameters, sex conversion and survival rate were examined. In t...
Khlood G. Abdelkhalek*, Aly B. A. Badawy, Mohamed Fathi, Elshymaa A. Abdelnaby
...estradiol 17β (E2), testosterone (T), and serum nitric oxide metabolites (NOMs) were measured in 5 Baladi bucks weighting (13–15 kg; with a body condition score of 3.5 ± 0.01) from 4-months- to 10-months-old in relation to testicular hemodynamics. Testicular morphometry, scrotal circumference, Doppler examinations, image analysis, and blood sampling were performed on a weekly basis. Results showed that FSH level was elevated (P<0.05) first...
Wassan Mhammed Husain1*, Zainab Sattar Ali2
...(p≤0. 05) decrease in testosterone, somatic testicular index, and sperm quality in the G3 group, nevertheless, there was a significant (P<0.05) increase in LH, FSH, sperm abnormalities percent, and dead sperm percent in the G3 group. The capacity of Phitofert ® to restore all passive effects of CCL4 and increase epididymal sperm quality was demonstrated in G4 groups.
Keywords | CCl4, Phitofert ®, Epididymal sperm, Testicular somatic index...
Nacira Djabali1*, Souad Dougat2, Wahida Haddadi2 and Lamis Fadhli2
...mone (FSH), the level of testosterone, the biological characteristics of the sperm, the weight and the histopathology of the testes were studied. The results obtained show a significant dose-dependent decrease in LH, FSH and testosterone in the treated groups compared to control. The administered solvent caused severe deterioration in sperm quality, decreased sperm concentration, mobility and vitality, with increased sperm m...
A.M. Abdul Azeem, Ashraf M. Mounir and Amr N. El-Shahat*
...ne, leutinizing hormone, testosterone and testicular antioxidant parameters (glutathione content , the activity of xanthine dehydrogenase, superoxide dismutase and catalase) in the group of alloxan (150 mg/kg B.WT)-administrated rats as compared to control group. Treatment of diabetic rats with GPSDP (1 g/kg B.Wt/day/ 8 weeks) resulted in significant reduction of glucose level and lipid-peroxidation with amelioration of hormonal disturbance and enhancement of ...
Nour El-Hoda Khayrat Hammad1*, Yousef Y. El-Seady3, Azza E. Hassan1, Sara T. Elazab2, Magdy S. Amer2
...ficant decrease in serum testosterone hormonal levels and spermatozoa (viability and motility) which accompanied by some histopathological damage in testes and epididymis. On a molecular basis, mRNA expression of CYP17A1 and LHR genes were significantly reduced in testicular tissues of FCZ group while aromatase gene was elevated. The administration of LIN oil after FCZ treatment markedly improved the aforementioned alterations caused by FCZ. So linseed oil is ...
Neda Amani1, Mehrdad Shariati1, Rahim Ahmadi2,3*, Mokhtar Mokhtari1 and Saeed Khatamsaz1
...y;">Cytotoxic effects of testosterone on cancer cells have been reported in recent studies, however, the molecular pathway is unclear. This study aimed to investigate the effects of testosterone enanthate on expression level of iNOS, MMP9 and caspase-3, -8 and -9 in human colon (HCT) and gastric (AGS) cancer cells. Cell lines were divided into untreated (control) group and groups exposed to 0.001, 0.01, 0.1, 1 and 10 mg/ml o...
Khaled El-Kholy1*, Yaser Rizk2, Mohamed El-Helbawy1, Eman El-Said1
...lative weight of fur and testosterone hormone levels were observed in rabbits injected with low level of clove oil (T3) compared with other treatment groups. In conclusion, clove oil at 12.5 µml., may be useful for improving growth performance, and increases the release of Gonadotropin-releasing hormone.
Keywords | Clove oil, Growth performance, Hormones, Rabbits, Salbutamol
...
Emtenan M. Hanafi1*, Fouad M. Tawfeek2, Walid S. El Nattat1, Moetazza M. Alshafei3, Seham S. Kassem3, Kawkab A. Ahmed4, Enas N. Danial5, Hagar Elbakry3, Hoda S. El-Sayed2
...markers and low level of testosterone and the epididymal Spermatozoa had low sperm viability and higher abnormalities than control group. Feeding the microcapsules (G2,G3) improved the animals’ health condition. Animals in G2 showed good spermatozoa profile while, those fed SP (G3) showed low sperm count and motility. Histopathological examination declared testicular degeneration in G1 and G3 and a high spermatogenesis in G2 compared to control group. It...
Hamdy Abdala Elnagar, Wael Mohamed Wafa*, Abdelaziz Mustafa Sakr, Mohammed Mahmoud Hegazy
...changes in the levels of testosterone (TES), leptin, and prolactin (PRL) in the blood and their relationships with age advancing of Egyptian buffalo males from one up to 24 month of age. Blood samples were taken from 66 male buffalo calves at 1, 3, 6, 12, 18 and 24 month of age (11 animals at every age). TES, leptin and PRL levels were determined in blood plasma. Results showed insignificant increase in TES and PRL by age advancing at 1-3 month, and in leptin ...
Jiahua Peng1,2, Shiyao Hua3* and Qian Wu4
...he changes in content of testosterone (T), follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were detected. The fasting blood glucose, serum insulin and insulin sensitive index changes were analyzed. The RT-PCR method was used to detect ovarian tissue TNF alpha and the level of IL-6 gene expression; Western blot was used to detect the changes in the expression levels of IKKβ and NF-κB protein expression. The results of fasting blood gl...
Ibrahim El-Ratel1*, Mostafa El-Moghazy2, Amira El-Gaml2, Ibrahim Abu El-Naser2
...ne, luteinizing hormone, testosterone, immunoglobulin, and antibody titer, while reduced lysozyme. All PEE levels improved antioxidants capacity, while reduced malondialdehyde in blood serum and in seminal plasma. Advanced motility, membrane integrity, livability and sperm viability were improved, but sperm abnormality, apoptosis and necrosis were reduced in cryopreserved semen by all PEE levels. Total antioxidants capacity was increased, while malondialdehyde...
Maha Mostafa1, Sohail Soliman1, Reham I. Mohamed2 and Wael M. El-Sayed1*
...were orally administered testosterone at 25 mg/kg for 35 days. The males were allowed to mate with females to estimate the fertility index. After the end of treatment, mice were sacrificed, blood was collected for biochemical analysis, and sex organs were dissected out for histological preparations. Administration of testosterone has significantly increased the body weight and decreased the gonad weight in both sexes. It dra...
Ibrahim Samir Abd El-Hamid1, Alaa Emara Rabee2, Moustafa Mohamed M. A. Ghandour2, Rasha Salah Mohammed3, Ahmed Mohamed. Sallam4
...mbrane integrity. Plasma testosterone concentration and number of red blood cells were higher (P≤0.05) in both treated groups. However alanine aminotransferase, cholesterol, total antioxidant capacity and glutathione peroxidase levels were reduced (P≤0.05) in both treated groups. It can be noted that, supplementing of plant herbs mixtures had positive effects on some reproduction and immunological traits in goat males under heat stress conditions.
<...
Doaa H. Assar1, Rasha A. Al-Wakeel2, Zizy I. Elbialy3, Mahmoud M. El-Maghraby4, Helmy K. Zaghlool5, Adel A. El-Badawy4, Abdel-Khalek E. Abdel-Khalek6*
...gh-density lipoproteins, testosterone, and thyroid hormones (T3 and T4), and significantly decreased activity of aspartate and alanine transaminases (AST and ALT), triglycerides, cholesterol, low-density lipoproteins (LDL), very-LDL, and urea. Semen variables including semen volume, and percentages of sperm motility, livability, and abnormality as well as concentration and output of sperm cells were significantly by SPL. In serum and seminal plasma, glutathion...
Moustafa M. Zeitoun 1,3; Mohamed M. Mansour 2,4*
...l plasma aldosterone and testosterone levels of male dromedary camels and their outcome on semen parameters and fertility. Methods; From breeding history records, depending on fertility status, sixty camels had divided into two groups; control “fertile” (n = 20) and infertile (n = 40). Blood and seminal plasma have obtained from all camels for hormone analysis. Results; Blood testosterone level was lower (p < ...
Ayoola J. Shoyombo1, Ake A. Moses1, Comfort I. Ukim2, Mustapha A. Popoola2, Olayinka O. Alabi1, Noah C. Edozie1, Faith Ogbor1, Jacob Kuusu1, Ekemini M. Okon3*
...ing the wet season. Only testosterone was significantly (p<0.05) higher in the wet season compared to the dry season in WAD bucks. All other measured hormones in WAD bucks showed no clear pattern. This study hypothesized that the seasonal effect is more pronounced in the female gender than in the male. Also, both genders tend to be significantly influenced by seasonal variations regarding their reproductive physiology; thus, proper management procedures mus...
Zainab Sattar Ali* , Safa Azhar Razzaq , Layla Hammody Hashem
...ration value of FSH, LH, testosterone, and inhibin B hormone for each of groups above. At the termination of experiment were taken in from them specimen of testes for a purpose pathohistology study and assessed the percentage of DNA fragmentation. The current study observed damage in this sperms DNA and alteration of histopathological section. In addition reduction the levels of testosterone, inhibin b, FSH and LH hormones i...
Ahmed H. El-Anwar, Eid A. Mabrouk, Khaled M. Ali, Nermeen A. Helmy, Rehab M. Reda*
... and thyroxine (T4), and testosterone were recorded monthly. The study also extended to examine androgen receptor (AR) gene expression and microscopical structure of testicular tissue at the end of the 5th-month-old. Results revealed that the n-ZnO group exhibited significant (P ≤ 0.05) improvement over that of the ZnO group on all growth performances and serum biochemical parameters compared with the control group except for FC, T3, and T4, which wer...
Kanwal Nisa1, Sadia Roshan1, Shazia Shamas1,2*, Raheela Atta Mustafa3, Shamaila Irum1, Kalsoom Sughra4 and Memoona Iqbal1
...on between the levels of testosterone with prostate cancer patients by the evaluation of a tumor marker Prostate-specific antigen (PSA). Prevalence was recorded in Gujrat, Punjab, Pakistan. Blood samples of normal and prostate cancer males were taken from Gujrat, Punjab, Pakistan. Information including age, marital status, smoking, Prostate-specific antigen (PSA), testosterone, and any previous record was obtained with the p...
Amer Hakeem Chyad1, Omar S.I. Al-Janabi2*, Orooba Mohammed Saeed Ibrahim1, Najeeb Mohaamed Hussein3
...ters (sperm count, total testosterone levels, FSH, and LH) compared to the CP group (P 0.05). Root extract of Chelidonium majus L. can be administered. Increase in all parameters and decrease in CP’s adverse effects on the testis.
Keywords | Herbal medicine, Biochemical indices, Chelidonium majus L. roots extract, Sperm count, Testosterone, FSH, LH and Cycloph...
Budianto Panjaitan1, Husnurrizal Husnurrizal2, V.Y. Edward3, D.A. Nishcaya3, Teuku Armansyah4, Tongku Nizwan Siregar2, Mulyadi Adam5, Arman Sayuti1, Amalia Sutriana4, Hafizuddin Hafizuddin2*
...ave a positive effect on testosterone concentration. This research aimed to determine the effect of PGF2α injection and the optimal time for sample collection on improving semen quality and testosterone concentrations in Aceh bull. Aceh bull was used in this study and allotted into two treatments. In treatment 1 (P1), the bull received 25.0 mg PGF2α (Lutalyse™, dinoprost, tromethamine) 1 hour before semen c...
Makruf Arif1*, Claude Mona Airin1, Dwi Sunu Datrianto2, Vincentia Trisna Yoelinda1, Sarmin1, Yuda Heru Fibrianto1, Pudji Astuti1
...minated the influence of testosterone hormone and stress on bird songs, with the stress response being measured by their corticosterone levels. Since the data about Stone Magpie testosterone and corticosterone levels during songbird competition remains unreported, this study aims to investigate testosterone and corticosterone hormone levels in Stone Magpies before and after the songbird co...
Nittaya Thongtip1, Sukanya Poolthajit1, Sirikhan Thartrak1, Qiongxian Yan2, Suntorn Wittayakun1*
...8), TSH (p = 0.403), and testosterone (p = 0.671). These results suggest that supplements did not significantly affect feed and nutrient intake, complete blood count, blood metabolites, and hormones. However, there was little benefit to animal health when growing male goats were fed high-concentrate diets. Further longer-term trials should be conducted to determine additional effects on productive performance and changes in semen quality. ...
Ali Bouzekri1,2*, Souheila Slimani1,2, Meryem Nassar1,2, Souad Zaaboub3 and Nora Sakhraoui1
...imulating hormone (FSH), testosterone (T), total cholesterol (TC), LDL-C, HDL-C, and triglyceride (TG) were evaluated at week 10. The obtained data reveal that under a long photoperiod of 19L:5D, sexual activity lasted only 06 weeks in the control and TT groups, with a significant increase in testicular volume followed by spontaneous gonadal regression up to week 10. But testicular weights were superior in TT pigeons compared to the control during all experime...
Wei Li1, Xvming Qi2, Xueli Lu3, Li Yuan4 and Huaiqing Deng1*
...vels of progesterone and testosterone were analyzed by high-performance liquid chromatography mass spectrometry. The results showed that the menstrual cycle of adult females in Hainan gibbon group C was 32±3.6 days and the duration of the menstrual period was 10±2.4 days. There was no significant difference in progesterone levels between individuals of different age and sex classes, no significant periodicity in the change of
Farhatul-Ain Arshad1, Asia Bibi1*, Amna Mushtaq1, Rubaida Mehmood2 and Nahid Kausar1
...m TG/HDL ratio, LH, FSH, testosterone and progesterone levels were significantly higher in non-obese cases as compared to non-obese controls. Taken together, we showed that obesity is not an exclusive factor involved in the development of PCOS. The occurrence and prevalence of PCOS are attributed to multiple alternative factors which warrant future studies comprising of larger cohorts and at the national levels....
Hind A.Norii1, Adel M.Hassen ALZobidy2*
...increased in the hormone testosterone and prolactin was noticed in the group of PCO. The ameliorative effect of extract of VAC was clearly observed at doses of 150 and 250 mg/kg bw on the release of estrogen and progesterone. Taken together, our findings illustrate that Vitex agnus-castus alcoholic extract impact the physiological parameters of female rats....
Husnurrizal Husnurrizal1,2, Hafizuddin Hafizuddin2*, Sri Wahyuni3, Cut Nila Thasmi2, Tongku Nizwan Siregar2,4
... of spermatozoa quality, testosterone, cyclic adenosine monophosphate (cAMP), and adenosine triphosphate (ATP) levels. A total of 15 rats (Rattus norvegicus) categorized into five treatment groups (n=3) were used in this study. In the control group (P0), the semen and blood samples were collected 30 minutes after a 0.5 ml NaCL injection. In groups P1, P2, P3, and P4, semen and blood samples were collected 30, 60, 90, and 120 minutes, respectively, after intrap...
Truong Thanh Trung1, Nguyen Thi Kim Dong2, Tran Long Hai1
Al-Moataz Bellah Mahfouz Shaarawy1, Mahmoud Yassin Mohamed1*, Mahmoud Sayed Sayah2,1, Ashraf Ali Mehany1, Ezzat Arafa Ahmed El-Beltagi1, Shimaa M. Ali1
...emen characteristics and testosterone levels for bulls developed earlier than the 1st group. Heifers in the same group were superior in reproductive performance such as reaching puberty, and fertility compared to other groups. The 3rd group showed the highest concentrations of serum proteins, glucose, and lipid profiles. The 2nd group came next, and 1st group registered the lowest concentrations. In conclusion, data on GH and LP levels from birth to weaning co...
Aya Salah Eldin Mohamed1*, Gamal E. Shams1, Gihan G. Moustafa2, Reda M. Abd El-Aziz3
...05) alterations in serum testosterone (TS) level when compared to the control group. Treatments by citalopram plus ginseng, vitamin D, or both caused significant declines in the circulating serum TS (p<0.01), LH (p<0.001), and FSH (p<0.001) levels matching to G2. Citalopram had detrimental effects on male rat fertility, as evidenced by a significant reduction (p<0.0001) in sperm counts and motility and a large rise (p<0.0001) in the percentage o...
Shimaa R. Hamam, Reham A. El-shafei, Nani N. Abdelaziz, Magdy S. Amer
...age to measure levels of testosterone, luteinizing hormone and follicle stimulating hormone. Furthermore, samples from the testis, epididymis, and seminal vesicles were taken at the second week of treatment to perform a histopathological analysis, analyze the semen profile and measure the activities of the enzymes glutathione-s-transferase and nitric oxide in the testicles. Testicular GST and NO activities, as well as the level of test...
Manar Mousa Alhussein*, Eman Faisal Albghdady
...s were taken to estimate testosterone and estrogen serum concentrations using competitive ELISA kits. The scrotum was dissected, the epididymis detached from the testis, and the weight and length were taken, then divided into three divisions (caput, corpus, and cauda) for histopathological study. HandE staining was used to detect general structures and histopathological changes. Special stains are used to detect collagen fibers, and mucopolysaccharide. The tre...
N. M. Abed
...T3, T4, TSH, LH, FSH and testosterone in the rats after four weeks of medication. Results analysis indicated a significant increase (P≤ 0.05) in TSH and lower T3 and T4 levels in the NiCl2, CCl4 and NiCl2+ CCl4 groups compared to the control group. Propolis treatment in the NiCl2 and CCl4 groups significantly (P < 0.05) lowered TSH levels compared to the control group. In contrast, the CPF-treated group had significantly higher serum levels. Our investig...
Dheyab D. Radhi1*, Rasheed H.A. Al-Aidi2, Ali Ahmed Khalaf 3
...indicators including LH, testosterone, ALT, AST, and glucose in blood serum was also observed.
Keywords | Iraqi sheep, L-carnitine, Sperm quality, Sexual ability
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