Vol. 54, Iss. 6, Pages 2501-3000

Chemoprotective Effect of Daphnetin against Benzene Induced Leukemia Cancer via Alteration of CYP2E1

Junling Liu, Chen Sun, Qiao Yu, Yanzhi Liang, Shanshan Lin, Meng Tian

Leukemia is a malignant disease of blood forming tissue inducing the over-production of large number of immature blood cells that enter the peripheral blood. Leukemia considered as the 9th most common cancer in men and 12th in women. Available treatment for le…

Effect of Low Molecular Weight Heparin Calcium Combined with Argatroban on the Treatment, Vascular Endothelial Function, Inflammatory Factors and Serum Neurological Function in Patients with Acute Cerebral Infarction

Xiaoli Yao, Xiaofang Yue, Yue Yang, Guobin Zhang

The objective of this study was to observe the effects of low-molecular-weight heparin calcium (LMWHC) combined with argatroban on the treatment, vascular endothelial function, inflammatory factors and neurological function in patient with acute cerebral infar…

Identification and Characterization of a Novel Type of Cartilage Stem/ Progenitor Cells from Tibetan Mastiff

Caiyun Ma, Hebao Wen, Lu Li, Gaofeng Liu, Chunjing Wang, Yu Guo et al.

Based on the physiologically non-self-renewing property of articular cartilage, the treatment of articular cartilage lesions remains an important challenge. Articular cartilage, the target of osteoarthritis (OA), contains renewable cartilage stem/progenitor ce…

Documenting Nesting and Breeding Ecology with Time Activity Budget of White-throated Kingfisher (Halcyon smyrnensis) in Swat, Pakistan

Ejaz Ur Rehman, Shakeel Ahmad, Fathul Bari, Tanveer Khan, Naveed Ullah Khan, Abdullah Khan et al.

White-throated kingfisher Halcyon smyrensis is a common resident of wetlands in Asia including Pakistan. Breeding ecology and time budget activity was investigated in 16 active nests at 6 different sites during the current study. Nest construction was primaril…

Association of rs 9340799 and rs 224693 SNPs in Estrogen Receptor Gene with Breast Cancer

Muhammad Ismail, Jabbar Khan, Zahid Rauf, Khalid Khan, Muhammad Rafi

It was attempted to molecularly characterize breast cancer patients of district Bannu, KP, Pakistan for any possible polymorphism in the estrogen receptor (ESR1) gene. Blood samples in this regard were collected from clinically diagnosed eighteen breast cancer…

Alteration in Blood Stress Marker and Other Vitals of Saudi Medicos in Pre- and Post-Real Time Cardiac Catheterization Procedure

Maher Mohammed Yousef Alobaysi, Turki Albacker, Waleed Alharbi, Osama Almogbel, Sadik Mohammed, Fahad Al-Abbasi et al.

Present work is a prospective cohort study that deciphers the alteration in stress marker and blood profile among trainee medicos during pre and post cardiac catherization procedure. Total 25 medicos were enrolled, only 10 were able to complete the criteria fo…

First Record of Balashark, Balantiocheilos melanopterus (Bleeker, 1850), in the Muara Angke Wildlife Reserve, North Jakarta, Indonesia

Gema Wahyudewantoro, Rahmi Dina, Haryono, Sekar Larashati, Siti Aisyah, Sopian Sauri

Balashark, Balantiocheilus melanopterus (Bleeker, 1850), has been discovered for the first time in the swamp inside Muara Angke Wildlife Reserve, Jakarta, Indonesia. Balashark in Indonesia is originally distributed in Sumatra and Kalimantan. However, the fish…

Effect of Dexamethasone Combined with Ganglioside on Acute Carbon Monoxide Poisoning and its Influence on Cognitive Function

Huajun Lin, Wei Qu, Zhuxian Yu

This study aims to investigate the efficacy of dexamethasone (Dex) with ganglioside in the treatment of patients with acute carbon monoxide poisoning (ACMP) and its effect on patients’ cognitive function. A total of 64 patients with ACMP treated in our h…

Length Weight Relationships of Commercial Fishes from the Mainstream of Yellow River, China

Jun Wang, Xiaoming Jiang, Zhiwei Sun

The present study estimates length-weight relationships (LWRs) of fish species from the mainstream of the Yellow River, which is the largest sediment-laden river in the world. A total of 1168 specimens belonging to 4 families and 18 species were analysed. The…

Fishery Stock Appraisal of Trichiurus lepturus (Linneaus, 1758) by using SPMs: A Case Study of Shandong, China

Zhang Yan, Muhammad Mohsin

Stock assessment of commercial fisheries is very important to ensure sustainable harvesting of fishery resources in China. Therefore, this study endeavors to estimate the fishery status of Trichiurus lepturus in Shandong, China. For this purpose, fishery stati…

Irrigation Stress to Wheat at Sensitive Growth Stages: Tri-trophic Effects and Implications for Aphid Control

Shahbaz Ahmed, Mubeen Ahmad, Muhammad Razaq, Farhan Mahmood Shah

Weather extremes can have profound impact on plant physiology. The altered physiology of stressed plant can also modify trophic interactions in that plant environment. Aphids are important pests of wheat crop causing direct or indirect injury to the crop. The…

Interrelationship Between Rumen Fluid Minerals and Biological Tissues of Growing Lambs Fed Complete Feed Supplemented with Clionptilolite

Mutassim Abdelrahman, Ibrahim Alhidary, Majdi Bahaddi, Mohsen Alobre, Riyadh Aljumaah, Rifat Ullah Khan

This study aimed to investigate the effect of feeding of complete feed with two levels of Zeolite (1% and 2%) on aluminium (Al), chromium (Cr), manganese (Mn), and potassium (K) status in rumen fluid and different biological tissues of growing Naemi lambs. Twe…

Comparative Performance of Three Silkworm Races Fed on Local Mulberry against Biological and Commercial Parameters

Sharon Zulfiqar, Mubashar Hussain, Kiran Aftab, Muhammad Faheem Malik, Rizwan Khursheed, Somia Liaqat et al.

We evaluated the performance of biological and commercial parameters of three bivoltine silkworm races fed on local mulberry. The disease-free eggs of Chinese, Korean and Bulgarian races were obtained from Sericulture Research Laboratory, Lahore. The silkworm…

Screening of Selected Canola Genotypes against Mustard Aphid (Lipaphis erysimi (K.) Hemiptera: Aphididae) through Antixenosis and Antibiosis Assays

Noor Muhammad, Shah Alam Khan

The study on categories of resistance in selected canola genotypes against mustard aphid (Lipaphis erysimi) was conducted under glasshouse conditions, The University of Agriculture, Peshawar during growing seasons of 2018-2019. During this study, a total of tw…

Effect of Feeding Methods on Rumen Bacterial Flora in Chinese Tan Sheep Based on 16S rDNA High-throughput Analysis

Jie Zhang, Na Li, Tingting Guo, Dandan Hu, Xiaofeng XU, Lili Zhang

This study examined the effect of different feeding methods on the rumen bacterial flora of Tan sheep, a Chinese indigenous breed, using 16S rDNA high-throughput analysis. The rumen fluid was collected from 9-month-old Tan sheep that were either house-fed or g…

Java Sparrow Bird Sex Detection Through Texture Analysis and Beak Image Color

Agus Mulyono

Java sparrow is a member of a monomorphic group. Males and females have a physical appearance that looks the same, especially the color of their fur. Limited information regarding the characteristics and behavior of male and female Java sparrows can cause prob…

Comparison of Fattening Performances and Meat Yield in Meat Type Kids and Lambs

Murat DurmuÅŸ, Nazan Koluman

The aim of the present study was to compare the fattening performance and carcass characteristics of the offsprings obtained from meat-type crossbreed sheep and goats. For this purpose, 10 head of lambs of the Cukurova Assaf type (75% Ost-Friz + 25% Awassi) an…

Effect of Sodium Hyaluronate and Betamethasone Injection in Knuckle Articular Cavity on Serum Inflammatory Factors and Metalloproteinase of Knee Osteoarthritis Patients

Zhaojun Wang, Yang Zhou, Xinghua Song

The aim of this study was to observe the efficacy of injection of sodium hyaluronate combined with betamethasone into knuckle articular cavity in knee osteoarthritis treatment, and to analyze its effect on the prognosis of knee joint function. A total of 120 k…

Effect of Organic Acids and Probiotics on Growth of Apis mellifera Workers

Ali Hasan, Javed Iqbal Qazi, Nasreen Muzaffer, Shamsa Jabeen, Ali Hussain

In the present investigation, effects of organic acids and probiotics on growth of Apis mellifera workers were studied under different experimental conditions. Significant weight gain was observed in workers of the experimental group 8 (pollen + Bacillus claus…

CDS Cloning, Sequencing and Bioinformatic Analysis of Vasoactive Intestinal Peptide in Wahui Pigeon

Fei Wang, Xiaofen Hu, Feng Wen, Xiaoen Tang, Shanshan Yang, Shengwei Zhong et al.

Vasoactive intestinal peptide plays double roles as gastrointestinal hormone and neuropeptide. Due to few reports on vasoactive intestinal peptide in pigeon, the present study was aim to further explore the correlation between its molecular bioinformatics char…

Liver Metabolism Adaptation to High-Concentrate Diet-Induced Milk Fat Depression

Lin Li, Pingsheng Ye, Xi Chen, Shuping Yan, Yuanshu Zhang

The high concentrate/low forage (HC/LF) diets cause a dramatic decline in milk fat secretion. Hepatic lipid metabolism is active when ruminant is on lactation period. The aim of this study was to evaluate liver metabolism adaptation to high-concentrate diet-in…

Effect of Subclinical Coxiellosis (Q fever) on Selected Hematological and Serum Biochemical Variables of Naturally Infected Camels

Shujaat Hussain, Muhammad Saqib, Khurram Ashfaq, Zia ud Din Sindhu

Coxiellosis, a widely dispersed zoonotic disease due to Coxiella burnetii, serve as a key trade barrier and adversely influence the productive and reproductive potential of animals. The current investigation was designed to determine the selective hemato-bioch…

Enamel Hypoplasia Analysis of Middle Miocene Mammals from Chabbar Syedan, Punjab, Pakistan

Muhammad Khalil Nawaz, Muhammad Akbar Khan

The present article is the first ever report on occurrence of enamel hypoplasia (EH) in extinct mammals of Chabbar Syedan. Three types of EH were observed: single linear hypoplasia, multiple linear hypoplasia and pitting enamel hypoplasia. Single linear hypopl…

Biochemical Profiling of Arsenic Trioxide-Induced Impaired Carbohydrate Metabolism and its Therapeutic Intervention via Modulation of Metabolic Pathways

Muhammad Sajid Hamid Akash, Hina Sharif, Kanwal Rehman, Sumbal Rasheed, Shagufta Kamal

We aimed to investigate the impact of arsenic trioxide (ATO) in impairing carbohydrate metabolism and therapeutic potential of resveratrol (RSV) to treat ATO-induced metabolic disorder. Twenty Wistar rats were used for this study; one group was normal control…

Ni Oxide Nanoparticles has the Potential to Drastically Affect the Behavior of Albino Mice in a Sex Specific Manner

Malik Fiaz Hussain, Atif Akbar, Muhammad Asif, Laraib Nisar, Muhammad Naeem Ashiq, Furhan Iqbal

Ni oxide nanoparticles (NiO NPs) are extensively used in industries dealing with welding, electroplating and in production of alloys but despite of their large scale uses, it is expected that they might have lot more drawbacks than their bulky counter parts. P…

Effect of Artificial Saliva Supplementation on Growth, Rumen Characteristics and Fecal Odor of Growing Naeemi Lambs Fed Total Mixed Ration

Mutassim M. Abdelrahman, Ibrahim Alhidary, Mohsen Alobre, Riyadh S. Aljumaah, Rifat Ullah Khan

We investigated the effect of feeding a complete feed as a total mixed ration (TMR) with different levels of artificial saliva (AS) on the rumen pH, epithelial tissues pigmentation, fecal odor and status of some trace minerals. Forty-five growing lambs were us…

Evaluation of Antimicrobial Activity of Organic Acids against Campylobacter jejuni in Broilers

Faiza Ghazanfar, Masood Rabbani, Aamir Ghafoor, Muhammad Hassan Mushtaq

Campylobacteriosis is a collective term used for the infection caused by the members of Campylobacter species. The causative agent is Campylobacter that asymptomatically colonizes broilers during development and contaminates it during slaughter. Outbreaks most…

MiR-216b-5p and HDAC8 Inhibit Breast Cancer Cell Proliferation, Metastasis and Invasion

Qi Zhuo, Yuanchun Yao, Meisongzhu Yang, Jinhua Chen, Miao Tian

The objective of this study was to investigate the mechanism of MiR-216b-5p and HDAC8 inhibiting the proliferation, metastasis and invasion of breast cancer cells. Tissue samples (28) were collected, and malignant and normal tissues were confirmed pathological…

Use of Growth Promoter in Feed: Tylosin Phosphate and Oxytetracycline Di-Hydrate Show Synergistic Effect on the Haematological Parameters and Biochemical Components of Broiler Chicken Blood

Irfan Shahzad Sheikh, Syed Haseeb Shah, Niamatullah Kakar, Mohammad Masood Tariq, Muhammad Essa Kakar, Muhammad Zahid Mustafa

The antibiotic growth promoters (AGPs) are provided in poultry feeds as an additive on sub-therapeutic level. The in vivo study was designed to evaluate the effect of oxytetracycline di-hydrate (OXY) and tylosin phosphate (TP) on different blood physiological…

Huaier Aqueous Extract Mediates Keloid Cell Proliferation and Apoptosis by Regulating miR-128-3p / EPHB2

Xiaoguang Su, Yanjun Gao, Yanling Wang, Yaohui Ma

This study was aimed to investigate the effect of HAE on the proliferation and apoptosis of keloid fibroblasts and its mechanism. Primary HFB cells were isolated and cultured, and treated with different concentrations of HAE for 48 h. Cell viability was measur…

Oriental Skylark (Alauda gulgula) Nestling Morphometry and Feeding Habits in Bajaur Khyber-Pakhtunkhwa Pakistan

Rahmat Ullah Khan, Asif Sadam, Karim Gabol, Waheed Ali Panhwar, Sajid Mahmood, Mustafa Kamal et al.

The present investigation was aimed to improve the contemporary information about morphometry and diet of Oriental skylark Alauda gulgula nestling from hatching to 8th day very carefully during the breeding season (April, May, June, and July) 2019, in district…

Feeding Ecology, Threats and Conservation Management of Kalij Pheasant (Lophura leucomelanos) in Azad Jammu and Kashmir, Pakistan

Muhammad Furqan, Zulfiqar Ali

Pheasants are bioindicators of our ecosystem and their population is declining. We investigated diet composition and threats to kalij pheasant Lophura leucomelanos to prepare conservation and management strategies in Azad Jammu and Kashmir, Pakistan. The diet…

FK228 Ameliorates the Liver Toxicity and Oxidative Stress on Thiram-Induced Tibial Dyschondroplasia in Chicken

Muhammad Kashif Iqbal, Khalid Mehmood, Shakeel Ahmed, Fazul Nabi, Muhammad Arif Rizwan, Muhammad Kaleem et al.

Tibial dyschondroplasia (TD) is a disorder of rapidly growing avian species characterized by enlarge avascular growth plate with lesions in proximal tibiotarsal bone. The aim of present study was to investigate the antioxidant capacity of FK228 and role of vas…

Zinc in Alkaline Water (Zamzam) Ameliorates Doxorubicin induced Cardiac Remodeling

Mohammed A. Almujtaba, Turky Omar Asar, Salma Naqvi, Vikas Kumar, Fahad A. Al-Abbasi, Abdulbasit I. Al-Sieni et al.

The holy Zamzam water is believed to be beneficial in curing several diseases. Studies report that its alkaline nature renders it a therapeutic potential. We aimed to determine the effect of Zamzam water in doxorubicin induced cardiac remodeling in rats. Male…

Effects of Antibiotics on Growth Performance, Immune Response, and Intestinal Microflora of Broilers

Shahan Azeem, Muhammad Akram Muneer, Liaquat Ahmad, Sameera Akhtar, Talat Naseer Pasha

This study was conducted to evaluate the effects of flavomycin, lincomycin, and zinc bacitracin on body growth, morphometery of immune organs, Newcastle disease virus (NDV) and avian influenza virus (AIV) antibody response, intestinal microflora, and feed effi…

Pinocembrin Ameliorates Neuronal Cell Death by Regulating Autoimmune Signals

Hairul Islam M. Ibrahim, Abdalla A. Sayed, Abdel Naser A. Ahmed, Emad A. Ahmed

Pinocembrin is a type of flavonoid present in honey and propolis. It has high antioxidant and neuroprotective effect. The present study was designed to evaluate the immunomodulatory properties of pinocembrin (PCB) and the anti-apoptosis effects using in vitro…

Role of Glutathione S Transferase Polymorphism in the Pathogenesis of Cardiovascular Diseases: A Case Control Study

Muhammad Akram, Muhammad Imtiaz Shafiq, Amber Malik, Farmanullah Khan, Munir Ahmad Bhinder, Muhammad Sajjad

Cardiovascular diseases (CVDs) are major health problems all over the world. Oxidative stress contributes an important pathological role in the development of CVDs. To counter this oxidative stress, the most important natural antioxidant defense mechanisms inc…

Effect of Inhibitor UNC0642 on Expression of G9a and Its Proliferative and Apoptotic Markers in Breast Cancer Cell Line MCF-7

Afifa Yaqub, Mehroze Amin, Qindeel Fatima, Rabail Hassan Toor, Saira Aftab, Abdul Rauf Shakoori

G9a is a lysine methyltransferase that has been reported to downregulate the expression of tumor suppressor genes in a variety of cancerous cells. The present study explores the anti-cancer activity of UNC0642, a novel potent inhibitor of G9a in MCF-7 breast c…

Optimum Conditions for Enhanced Production of Podophyllotoxin from Penicillium sp. Isolated from Khanspur, Pakistan

Umar Farooq Gohar, Attia Majeed, Bushra Muneer, Hamid Mukhtar

Podophyllotoxin, a naturally occurring aryl tetralin lignan produced by few plant species and endophytic fungi is used as precursor for the chemical synthesis of the anticancer drugs. In the present study, for the isolation of podophyllotoxin producing endophy…

Prokaryotic Expression, Purification, and Functional Characterization of the Large Yellow Croaker (Larimichthys crocea) Mannose Receptors Subunits (MRC1 and MRC2)

Xiangli Dong, Shilin Mikhail Borisovich, Jiji Li, Jianyu He, Zeqin Fu, Yingying Ye et al.

The mannose receptor (MR) is an important receptor for the innate immune response. It is a member of the C-type lectin domain family, and has two subunits, MRC1 and MRC2. The MRC1 and MRC2 cDNA sequences have been analyzed and characterized in the large yellow…

Effect of Low Molecular Weight Heparin Calcium Combined with Argatroban on the Treatment, Vascular Endothelial Function, Inflammatory Factors and Serum Neurological Function in Patients with Acute Cerebral Infarction

Xiaoli Yao, Xiaofang Yue, Yue Yang, Guobin Zhang

The objective of this study was to observe the effects of low-molecular-weight heparin calcium (LMWHC) combined with argatroban on the treatment, vascular endothelial function, inflammatory factors and neurological function in patient with acute cerebral infar…

Association of Chemokine Genes CXCL9 and CXCL10 Polymorphisms with Tuberculosis in Pakistani Population

Saleha Tabassum, Muneeza Zafar, Munazza Raza Mirza, Muhammad Iqbal Choudhary, Ikram ul Haq, Imran Riaz Malik et al.

The CXCR3 ligand family, including CXCL9, CXCL10 and CXCL11, play important role in T-cell, natural killer (NK) cell, NKT cell and dendritic cell trafficking. These chemokines were suggested for their use as alternative markers for TB diagnosis, and their poss…

Relationship between Testicular Traits, Body Measurements and Body Weight in Boer Goat Bucks

Madumetja Cyril Mathapo, Thobela Louis Tyasi

The study was conducted to evaluate the relationships between testicular traits, body measurements and body weight. A total of twenty-five (25) Boer goat males aged between one and two years were used in the study. Testicular length (TL), scrotal circumference…

Improvement of Fertility Rate Using Ovsynch and Biostimulation Protocols with Timed Artificial Insemination in Thari Cattle

Ghulam Nabi Dahiri, Akeel Ahmed Memon, Qudratullah Kalwar, Asmatullah Kaka, Waseem Ali Vistro, Yar Muhammad Jalbani et al.

The study was carried out to compare efficacy of estrus synchronization protocols with or without biostimulation in Thari cattle. A total of forty Thari cattle maintained at semi intensive management conditions at Thari Cattle Farm Nabisir Road, Distt: Umerkot…

Stock Assessment of Trichiurus lepturus (Linneaus, 1758) in Zhejiang, China: A Proposal for Fishery Management

Qian Chong, Muhammad Mohsin, Zhu Ting, Chen Qiqi, Ana Mehak

Zhejiang province marine waters are a significant place of commercial fisheries in China as these resources are rich in fish fauna. However, decreased fish biomass catch has been observed during recent years, putting a big question about the ongoing stock stat…

Single Step Detergent Assisted Extraction and Solubilization of the Recombinant Matrix Protein of Newcastle Disease Virus (NDV) and Development of ELISA for Detection of Anti-NDV Antibodies in Chickens

Zahra Naz, Fouzia Ismat, Muhammad Saleem, Mazhar Iqbal, Aamir Shehzad, Moazur Rahman

The matrix (M) protein is the most abundant structural protein in Newcastle disease virus (NDV), the causative agent of Newcastle disease (ND) in chickens. Owing to its highly conserved nature among NDV strains and also due to its pivotal role in the viral lif…

Influence of Varying Dietary Cation-Anion Difference on Blood Metabolites of Holstein Dairy Cows

Hazem E. M. Hassanien, Awad M. M. Mahmoud, Elsayed M. Abdel-Raouf, Nabil M. Eweedah, Midhat. N. Nassif

A negative dietary cation-anion difference (DCAD) motivates a compensated metabolic acidosis, stimulating calcium (Ca) absorption and mobilization before calving and decreasing clinical and subclinical hypocalcemia postpartum. The objective of this trial was t…

Effect of Metformin on P53 and its Interacting Partners in Breast Cancer Cell Line MCF-7

Mehroze Amin, Afifa Yaqub, Qindeel Fatima, Rabail Hassan Toor, Abdul Rauf Shakoori

Metformin is known to favor p53 anti-cancer activity and promote apoptosis and cell senescence in cancer cells. It is also known to decrease the incidence of several cancers though it is not entirely true for breast cancer. In the present study, the effect of…

Plant Taste Affects Diet Selection by Plateau Zokors (Eospalax baileyi)

Shou-Dong Zhang, Dao-Xin Liu, Dan Mou, Tong-Zuo Zhang, Jian-Ping Su, Jiu-Xiang Xie

Diet selection can be influenced by many factors and is crucial for survival. In this study, we measured the diet selection (Ei index) of plateau zokors (Eospalax baileyi) by comparing the composition of plant species present in overwinter caches and inside ne…

Effect of Anthropogenic Disturbance Intensity on the Vigilance Mode of Wintering Hooded Crane (Grus monacha)

Xinran Wang, Lizhi Zhou

Wetland degradation has resulted in waterbirds choosing more habitats to forage and facing increased intensity of anthropogenic disturbance. Usually feeding in a large flock could provide safety by the vigilance partners through coordinated and synchronous vig…

Time-Based Effects of Xanthium strumarium Extract on Rats

Hakan Kececi, Yasin Ozturk, M. Bahaeddin Dortbudak, Seda Yakut, Gurdal Dagoglu, Merve Ozturk

This study is aimed to determine the toxicity of Xanthium strumarium L. (cocklebur) or its seeds to human or an animal. Cocklebur, potentially toxic plants is found abundantly in meadows and pastures. One of the most significant ingredients that causes toxicit…

Prokaryotic Expression of the Toxoplasma gondii SAG2 Gene in Pet Cats and Establishment of an Indirect ELISA Method

Liyun Chang, Aiju Liu, Jianshuang Zhang, Yingbin Chen, Zhiyong Liu

This study aimed to establish an indirect enzyme-linked immunosorbent assay (ELISA) method based on the SAG2 gene of Toxoplasma gondii (T. gondii) to improve the detection of toxoplasmosis in pet cats. Escherichia coli BL21 (DE3) was transformed with a prokary…

Evaluation of a Herbal Muco-adhesive Gel for Treatment of Oral Submucous Fibrosis in Wistar Rats

Iqra Ejaz, Saima Chaudhry, Sarah Ghafoor

The present study was designed to formulate and investigate the role of an oral muco-adhesive gel, having a novel combination of 1% curcumin and licorice, in an animal model of oral submucous fibrosis (OSMF), as a possible treatment modality. Animal model of O…

Effect of LncRNA TINCR on Hepatocellular Carcinoma Hep-3B Cell Growth and Chemosensitivity

Guang Yin, Wencheng Kong, Yuqiang Shan, Jian Zhang, Rongchao Ying, Sixin Zheng

Present study was aimed to investigate the effect of LncRNA TINCR on the proliferation, invasion, migration and chemotherapy sensitivity of hepatocellular carcinoma Hep-3B cells and its mechanism. In present study Hep-3B cells cultured in vitro were divided in…

In Vivo Effect of Novel Lytic Phage Cocktail against Salmonella Pullorum

Rida Haroon Durrani, Ali Ahmad Sheikh, Masood Rabbani, Muti-ur-Rehman Khan, Aneela Zameer Durrani, Salman Ashraf et al.

Despite advances, avian salmonellosis pose a major challenge to the poultry health, associated with high production losses. The study aimed to investigate the effect of oro-nasal phage delivery on bacterial population. As prophylaxis, oral phage delivery via d…

Quercetin Improves Liver Function, Decreases the Expression of Pro-apoptotic Proteins p53 and Bax and Increases the Antioxidant Defense of Hepatocytes in Aged Male Rats

Eman A. Al-Shahari, Eman R. ElBealy, Abdelhalim A. Alkhazendar, Abeer A. Alm-Eldeen

Aging is a natural biological process that leads to deterioration in the liver structures and functions due to oxidative stress and the reduction in the oxidative damage’s tolerance. Quercetin, a flavonoid has the ability to face the oxidative injury thr…

Efficacy of Anti-Müllerian Hormone in Predicting the Levels of Sex Hormones and Pregnancy Outcomes in Patients with Polycystic Ovary Syndrome Undergoing IVF-ET

Jiacheng Du, Yuping Cao

Our study aimed to explore the value of Anti-Mullerian hormone (AMH) level in sex hormone level and pregnancy outcome in patients with the polycystic ovarian syndrome (PCOS) who underwent Invitro fertilization-embryo transfer (IVF-ET). This study selected 200…

Analysis of Shisha Smoking Effect on Haematological Indices in Adult Smokers

Muhammad Hassan Naseem, Muhammad Mansha, Muhammad Triq, Peter C. Thomson

Shisha smoking is a rising trend among youth as a symbol of modernization and fashion. There is misconception that shisha smoking is less harmful than cigarette due to filtering effect of the liquid used in the device. The present study was conducted to invest…

Fish Diversity and Water Quality in Different Zones of Upper River Indus Basin, Pakistan

Zaidi Zona, Zulfiqar Ali, Rida Ahmad, Irfan Zainab

Water quality assessment and freshwater fish diversity of cold-water Indus River, along a 400-kilometer stretch from Raikot (upstream) to Tarbela (downstream) was examined during 2019. The river channel was divided into five zones such as Raikot-Basha, Basha-D…

Developmental Potential of Ovarian Follicles in Mammals: Involvement in Assisted Reproductive Techniques

Abd El-Nasser Ahmed Mohammed, Aiman Al Mufarji, Sultan Alawaid

Ovarian follicles develop through several distinct phases during fetal and postnatal periods and they release their matured ova upon puberty. A finite number of primordial follicles form in the fetal ovary from primordial germ cells (PG) during the first stage…

Efficacy of Low-Dose Epinephrine in Treatment of Severe Asthma

Fengbin Jin, Xin Liu, Yanqiu Yue

The objective of this study was to explore the efficacy of 0.25 mg dose of epinephrine as a low-dose on the severe asthma. A total of 114 patients with severe asthma of hospital were selected between December 2017 and February 2020 as the subjects of this stud…

Microplastics: Their Effects on Amphibians and Reptiles-A Review

Dong-Min Hou, Ding-Qi Rao

Although microplastics provide much convenience to humans, they also pose a threat to the ecological environment on which humans depend. Microplastics persist in the environment and spread throughout the planet through the atmosphere, ocean currents, wind and…

Bacterial Expression and Purification of Antigenic Recombinant Protein Encoded by Hepatitis Delta Virus Antigen of Pakistani Isolate

Iram Amin, Shazia Rafique, Nadeem Ahmed, Muhammad Shahid, Samia Afzal, Tahir Rehman Samiullah et al.

HBV is a global burden and co-infection of HBV/HDV causes additional risks and mortality rate. Currently, there is no vaccine available for HDV, therefore, treatment of patients with dual infection is indeed a challenge for clinicians. A timely and accurate di…

Serological Evidence of Bovine Herpes Virus-1 in Goats in Lahore, Pakistan

Amoon Danial, Shahan Azeem, Sohail Raza, Muhammad Hassan Mushtaq

Recently, BoHV-1 is detected with a 69% seroprevalence in the cattle sampled from Lahore and Rawalpindi districts of the Punjab Province of Pakistan. The objectives of the present study included evaluating the seroprevalence of BoHV-1 in goats accompanied by c…

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Effect of Peritoneal Dialysis on Sclerosin Level in Serum of Patients with Variable Calcification

Lei Xu, Qin Yang, XiaoYan Zhang

To observe the changes in the level of sclerosin in serum of patients after peritoneal dialysis (PD) and to analyze the underlying clinical factors, a total of 94 patients who were subjected to the peritoneal dialysis for over three months in the Nephrology De…