Mustafa Cengiz1*, Jama Hussein Ali2, H. Mehtap Kutlu2, Djanan Vejselova2 and Adnan Ayhanci3
...x and caspase-3-positive hepatocytes, a significantly increase in levels of the activities of biochemistry markers (serum alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP)). In contrast, in the groups given D-GaIN and EA, a decrease in the damage of the liver tissue, a significant decrease activated Bax and caspase-3-positive hepatocytes, while increase in the number of Bcl-2 positive
Pan Hong, Ruonan Li, Yumeng Li, Hainan Lan* and Xin Zheng*
...freshly isolated porcine hepatocytes were used as a somatic cell model to study the internalization and subcellular localization of porcine growth hormone (pGH), and the results showed that pGH could be internalized into porcine hepatocytes in a time-dependent manner. The results also showed that pGH could be translocated into cell nuclei in a time-dependent manner. In addition, the subcellular localization, according to imm...
Asma Karim1, Wajid Ali1*, Noreen Ahmad1, Muhammad Irfan2, Hafiz Abdullah Shakir3
Histological and biochemical study of liver of silver carp (Hypophthalmichthys molitrix) after acute exposure to pyrethoride (deltamethrin)
...pycnosis, hypertrophy of hepatocytes, vacuolization, nuclear atrophy and congestion
of blood vessels were observed as compare to control group. This result was also supported by the significant
increase in levels of hepatic enzymes AST and ALT in blood plasma of exposed fish as compared to control fish.
These results suggested that deltamethrin is highly toxic for aquatic organism like silver carp causing malfunctioning
of liver.
of blood vessels were observed as compare to control group. This result was also supported by the significant
increase in levels of hepatic enzymes AST and ALT in blood plasma of exposed fish as compared to control fish.
These results suggested that deltamethrin is highly toxic for aquatic organism like silver carp causing malfunctioning
of liver.
Aqsa Pervaiz1*, Rukhshanda Afridi1, Zahra Pervaiz1, Rabia Masood1 and Hira Pervaiz2
...c tissue, destruction of hepatocytes, degeneration of bile duct, inflammatory infiltration, vacuolization, pyknosis, presence of MMCs and necrosis in hepatocytes. It can be concludedthat methylmercury has harmful effects on histology of liver of fish. Therefore, the present work suggests that the exposure to the methylmercury should be prevented to avoid injurious health hazard risks to fish.
...
Gasem Mohammad Abu-Taweel
... of the cytoplasm of the hepatocytes, necrosis of hepatocytes, polymorphism of tissue, nuclei and vessel congestions when compared with control group. The development, behavioral, biochemical and histological disorders were observed due to exposure to mercury via placenta during pregnancy and / or during lactation through weaning period. Overall, mercury chloride administration had direct influence on the social behavioural ...
Mai A. Kilany1; Hanaa H.A. Gomaa1; Yousry E. Abo El-magd2 and Nermin Raafat2.
... oxygen species (ROS) in hepatocytes leading to their proliferation and triggers HCC. Manganese superoxide dismutase (MnSOD) is a nuclear-encoded antioxidant enzyme that neutralizes free radicals. Val16Ala single nucleotide polymorphism (SNP) is one of the most widely investigated SNPs in the MnSOD gene, where C to T transition resulting in the con-version of valine to alanine at amino acid 16 within the mitochondrial signaling se-quence. This study was design...
Sajida Batool1, Saira Batool1, Sitara Shameem1, Fatima Khalid1, Tahira Batool2, Summera Yasmeen1, Saima Batool3*
... massive degeneration of hepatocytes, deformed nuclei of hepatocytes, highly disordered trabecular arrangement, vacuolar degeneration, diffuse necrosis, congestion and degeneration of the hepatic portal vein. Micrometric data indicated a significant reduction in themean number of hepatocytes and oval cells per unit area in ATZ treated group as well as significantly increased size and nucle...
Mengke Wang1, Shucheng Huang2, Cai Zhang1*, Haizhou Gong1,
Shunan Cuan1, Shuaishuai Wang1, Qi Shao1, Wenhao Xu1, Sudan Meng1,
Pengfei Li1, Yuqin Wang1 and Zijun Yang1
...hat lipid deposition and hepatocytes apoptosis in the MAG treated groups were significantly lower than that in the control group. Blood biochemical indexes also revealed that MAG supplementation significantly decreased the activity of alanine aminotransferase (ALT) (p<0.05), the content of total protein (TP), albumin (ALB) and globulin (GLB) (p<0.05). Furthermore, supplementation of MAG increased the activity of total superoxide dismutase (T-SOD) (p<0...
Yonis Abukar Mohamed1, Md. Nazrul Islam1, Md. Haydar Ali1, Mahfuza Akther1 and Abdiaziz Idiris Mohamud2*
...e swelling of individual hepatocytes by increase in size and characterized by opaque cytoplasm. Sometime there was fatty change in which clear vacuoles appeared in the cytoplasm with peripherally located nuclei. Microscopically, depending on the duration and intensity of the infection, various changes were observed in the structures of fasciola infected cattle liver. Gross lesions of fascioliasis found in the liver were increase in the size of the organ and al...
Syed Shahid Imran Bukhari1*, Nusrat Jahan2, Muhammad Khalil Ahmed Khan3, Mariam Zaheer1, Sabir Javed1
...and lobular structure of hepatocytes.
Novelty Statement | This study reports that Aloe vera which is commonly grown in houses has very strong antidiabetic and antihyperlipidemic properties.
... 
Sozan A.A. Ismaeil1*, Hassan Emam2
...portal areas and between hepatocytes. Histochemical: in the liver of pigeons gave few amounts of reticular, collagen, and elastic fibers with silver, Crossman, and Orcein stains respectively and faint positive reaction with PAS while in the liver of Ibis was vice versa. This study aims to understand normal gross anatomy and histology of the liver in Young Homing Pigeons and Cattle Egrets. It can be concluded that the presence of gall bladder and absence of it ...
Barirah Rehman Talpur1, Zaheer Ahmed Nizamani1*, Imdad Hussain Leghari2, Mansoor Tariq1, Aisha Rehman3, Shahnawaz Kumbhar1
...nd fatty degeneration of hepatocytes. Kidney tissues of both rabbits and broilers revealed marked shrinkage of glomeruli with widened bowman’s spaces along with inflammatory cellular infiltration. It is concluded that high dose (200mg/l) of Sodium Fluoride causes liver and kidney dysfunction in both species along with lesions in digestive system of broilers.
Keywords | Fluorosis, Rabbits, Broilers, Liver, Kidney
...
Eman A. Al-Shahari1,2, Eman R. ElBealy3, Abdelhalim A. Alkhazendar4 and Abeer A. Alm-Eldeen4*
...e antioxidant defense of hepatocytes in aged male rats....
Sajida Batool*, Sitara Shameem, Kainat Malik and Aneela Iram
...an number of mononuclear hepatocytes was observed in all treated groups as compared to control. While, ACSA of mononuclear hepatocytes increased significantly (P<0.001) in the direct and glass container group as compared to control. Relative nucleo-cytoplasmic index of hepatocytes and mean number of oval and kupffer cells per unit area was significantly decreased in all treated groups a...
S. Feroza1, A. G. Arijo1†, F. M. Bilqees2 and M. S. Phulan1
...epatici and shrinkage of hepatocytes were found to have resulted into dilation of sinusoids....
Hussein Jabar Jasim1*, Amer Murhum Al-Amery2
... coagulative necrosis of hepatocytes with large numbers of inflammatory cell infiltration such as eosinophil, Kupffer cell and scattered lymphocytes in the area previously migrated by young flukes as well hepatocytes displayed a fatty change with dilated hepatic sinusoids. Furthermore, our findings show that the bile ducts have hyperplasia, which is associated with fibrous cholangitis and an abundance of inflammatory cells w...
Nawfal Hammadi Jasim1, Yasmeen Jassim Mohammed2 , Jala Amir Salman Alahmed1, Majdy Faisal Majeed3*
...ion of the central vein, hepatocytes degeneration, nuclei pyknotic, sinusoids dilation, and slight inflammation, while group 2 revealed severe damage mainly , lost the typical polymeric shape, hepatocytes alteration, hepatocytes vacuoles, necrotic foci, inflammation cells aggregation, sever dilated and congestion of sinusoids and nucleus pyknotic. Conclusion: These findings demonstrated th...
Mohamed Mahrous Amer1*, Hanaa Sayed Fedawy2, Hoda Mohamed Mekky2, Khaled Mohamed Elbayoumi2, Ahmed Ali El-Shemy3, Mohamed Abd El-Rahman Bosila2
...opic degeneration of the hepatocytes and congested splenic sinusoids. While treated groups showed limited skin inflammatory condition at the site of injection and return of skin to normal color and thickness. Doxycycline+ colistin combination helps in reduction of lesions in treat infected birds, with marked improvement in measured parameters. We recommended active actions to prevent causes and factors helping in including cellulitis, regular lowering bird den...
Samia Afzal1*, Jahanzaib Ahmad1, Iram Amin1, Liaqat Ali2, Muhammad Shahid1, Mohsin Ahmad Khan1 and Muhammad Idrees1
...lopment and release from hepatocytes. It causes the most severe viral hepatitis and suppresses the serological and molecular markers of HBV infections; for example, Hepatitis B envelope antigen (HBeAg), inhibition and reduction of HBV DNA titer during HDV infections. Very few studies described the clampdown of HBV-related markers during HDV replication and the current study is the only report from Pakistani perspective. The objective of this study is to find t...
Salma Jameel Askar
..., enlarged and apoptotic hepatocytes. Liver sections of G3 showed less side effect than Meloxicam-treated group. From this study concluded supplementation with beetroots ethanolic extract may attenuate the toxicity of Meloxicam, leading us to deduce that Meloxicam induces hepatotoxicity and creates abnormalities in hematological and biochemical markers. ...
Oghenebrorhie M. Oghenochuko1,4*, Olubukola T. Adenubi3, Olusola L. Ajayi3, Fakilahyel M. Mshelbwala3, Johnny O. Olukunle3, Samson A. Rahman3 and Godfrey N.O. Ezeri2
...ons were observed in the hepatocytes and epithelia cells in the kidney in some treatments especially in bath treatments. In conclusion, onion bulb showed no toxicity in the blood parameters but dose should be considered to avoid harmful effect on liver and kidneys....
Suhad Mohmmed Alrobyrai1 , Falah Muosa Al-Rekabi2*
...tions displayed necrotic hepatocytes in G3 after 30 days, and G4 showed normal features. G5 exhibited normal hepatocytes after 30 days, with mild cellular swelling after withdrawal. These findings suggest the potential of ALA and Tempol in mitigating APAP-induced subacute toxicity, indicating a promising therapeutic avenue. However, further research is essential to elucidate the precise mechanisms, and caution is warranted i...
Tayfun Karatas1*, Betul Apaydın Yıldırım2 and Serkan Yıldırım3
...s, and necrosis in liver hepatocytes as well as hyperemia and inflammation in the liver and caused degeneration, desquamation, necrosis and adhesion in the gill epithelium. Additionally, expression levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) and Caspase 3 were severe in the liver and gill tissues. However, both 50 and 100 mg doses of TLE had protective effects against CMN-induced toxicity in all the above parameters. As a result, we have shown that 100 mg of...
Sumaira Fiaz1*, Huma Naz1*, Tanveer Ahmed2*, Iqra Zulfiqar1, Khalid Mehmood1, Muhammad Jabbar1, Syed Qaswar Ali Shah1, Muhammad Usman4
...n liver, the diameter of hepatocytes was significantly lesser in Cd-treated fish in comparison with control fish. The width of sinusoids in Cd-treated fish was significantly greater in comparison with control fish. Some other histological disorders were also seen in liver of Cd-treated fish viz. infiltration of sinusoid, dilation and increased hemorrhage in sinusoids, inflammation and vacuolation in hepatocytes and ruptured ...
Fatima Aziz Mahdi Al-Badry
... well as necrosis of the hepatocytes. Conclusion: It was concluded in this study eating of Puma for long times causes renal-hepatic damages.
Keywords | Puma, (Super fat), Histopathological changes, Urea, Liver enzymes, Rats, Nutritional supplements, Biochemical indices, Traditional products
...
Duaa Jasim Mohammad
...sent around the affected hepatocytes. In contrast, liver of the untreated control group depicted normal histological features. Findings of this study articulate that halothane anesthesia can induce pathology in the liver of male white mice and offer consideration of mice as animal model to investigate useability, practicalities and implication of such anesthetic agents in animal health practices. ...
