Jixue Hou1,2, Xueling Chen3, Jing Wang4, Hongwei Zhang2, Yu Xi2, Jie Xia2, Xinyu Peng2,* and Xiangwei Wu2,5*
...hophysiologic process of cardiovascular disease, but for a long time it is just limited to large animals, like pigs, rabbits, and big rats. The mice with reproduction fast cycle, lower costing, and close to human genes, can be showed about some phenomenon quickly, also more easy to form model of atherosclerosis. Thus, a mouse model of vascular injury is vitally important for researching the pathophysiological mechanisms to restenosis after percutaneous translu...
K.N. ArulJothi1, M. Abinaya1, B. Suruthi Abirami1, Melvin George2, S. Elangovan3 and A. Devi1*
...evels and development of cardiovascular disease (CVD) in different populations. In this study, we investigated the association of rs5888 polymorphism with serum lipid levels and CVD risk in an Indian population. A total of 412 samples which included 148 myocardial infarction survivors, 162 Normolipidemic healthy controls and 102 patients with hypercholesterolemia in a Indian Tamilian population were included in the study. Genotyping of SCARB1 gen...
A. Hamid1,*, M. Ilyas2 and S. Kalsoom3
...holestrolemia leading to cardiovascular diseases are very common problem in Pakistan and in most cases it is caused due to insufficient intake of dietary fiber.A study was conducted to evaluate the role of dietary fiber and ß-glucan from major food grains used locally on plasma cholesterol level of dietary-induced hypercholesterolemic rats. Insoluble dietary fiber (lignin and cellulose) was extracted from wheat and maize, while ß glucan was extract...
Sana Qanber Abbasi1*, Ejaz Ahmed2 and Rabia Sattar1
Muhammad Kashif Maan1, Muhammad Arif Khan1, Shehla Gul Bokhari1, Muhammad Ijaz2, Hamid Akbar1, Sajid Umar 3 and Muhammad Luqman Sohail4,*
...he serum biochemical and cardiovascular effects of total intravenous anesthesia, xylzine-ketamine and inhalation anesthesia, isoflurane was clinically compared in healthy female rabbits (n=16) undergoing ovariohysterectomy. One group of 8 rabbits was anesthetized with combination of xylazine (3mg/kg) and ketamine (10mg/kg, I/V), while the second group (n=8) was pre-anesthetized with xylazine, followed by treatment with isoflurane (4%) with oxygen flow rate of ...
Kaleem Ullah1, Zafar Niaz2, Sami Ullah Mumtaz3, Sajid Abaidullah4*
...onary disease (COPD) and cardiovascular diseases strongly exists as diastolic dysfunction is commonly reported in COPD patients.
Objective: This study was conducted to determine the presence of left ventricular diastolic dysfunction in patients of COPD.
Material and Methods: A cross sectional study was conducted in Mayo Hospital Lahore for one year. A total of 50 confirmed cases of COPD were included in the study. History ...
Syeda Ain-ul-Batool1, Sadia1, Kathrin Blasius2,3,4, Angela Kaindl2,3,4 and Ghazanfar Ali1,*
...t, hirschsprung disease, cardiovascular and liver disorders. So far 21 genes are reported that cause BBS (BBS1-BBS21). A consanguineous family having clinical symptoms of BBS9 is described in current study. Mutation was detected in BBS9 on chromosome 7p14.3 using whole exome sequencing (WES). A splice acceptor site mutation (c.1131G>A) in exon 3 was revealed by Sanger sequencing.
... 
Ghulam Akbar1*, Muhammad Anjum Zia1, Ali Ahmad2, Neha Arooj1 and Shahneela Nusrat1
... all deaths occur due to cardiovascular diseases. Among fibrinolytic enzymes streptokinase (SK) is commonly used in the world to cure heart diseases because its low cost and efficacy. It’s a microbial origin enzyme produced especially by Streptococcus bacterial spp. Therefore, it is antigenic in nature due to microbial source which restricts its use. However, it is necessary to truncate antigenic regions present in the SK gene for the removal of streptok...
Xuya Zhou1, Ying Liu1, Deqin Xu1, Jie Bao1, Yaru Cao2 and Yong Jin3*
...ugs increase the risk of cardiovascular disease, such as thiazolidine diketone: rosiglitazone, selective cyclooxygenase (COX)-2 inhibitors: rofecoxib, celecoxib. This study was aimed to find out whether unification of two drugs would increase cardiovascular side effects. Type 2 diabetic rat model was induced through feeding with fodder containing high sugar and lipid and intraperitoneal injection of streptozotocin. The adjuv...
Ahmad Sadiq1, Muzafar Shah2*, Habib Ullah1, Irfan Ali1, Amir Alam3,
Navid Jalil1 and Muhammad Khan3
...ch are the main cause of cardiovascular diseases (CVD). The present work revealed the role of glycated hemoglobin (HbA1c) for the detection of lipid profile and CVD. In recent study 108 (56 males and 52 female) type 2 diabetes (T2DM) subjects were diagnosed at Hayatabad Medical Complex (HMC) Peshawar and private diabetic clinic “Khattak Medical Centre” (KMC), Dabgari Garden Peshawar, Khyber Pakhtunkhwa, Pakistan. The normal or control group consist...
Roheela Yasmeen1*, Nida Mobeen1 and Samia Chaudhry2
...d are reason for serious cardiovascular disease including myocardial injury. This virus can persuade cardiac damage, arrhythmias, severe coronary syndrome and venous thromboembolic complications. Patients of COVID-19 having already cardiovascular problems showed severe symptoms of this disease and have greater chance of death. This review article especially pays attention on cardiovascular...
Kanwal Haneef1,2, Rakhshinda Habib1,3, Nadia Naeem1,3 and Asmat Salim1,*
Meiping Deng1, Xiaowen Ye1, Jiashan Wu1, Lijuan Chen1, Xiaoxia Jiang1, Changzheng Zhang1, Peiling Zhou1* and Yi Luo2*
...t concerns regarding the cardiovascular effects of arecoline treatment in clinical practice.
... 
Blood Profile of Soybean Meal Substitution with Black Soldier Fly Larvae in New Zealand White Rabbit
Ardi Prasetio1*, Christina Maria Sri Lestari2, Sutaryo Sutaryo2, Manar Fayiz Mousa Atoum3,4, Muhammad Zahoor5, Asma Nisar6 and Muhannad Illayan Massadeh7
...that can lead to several cardiovascular diseases. Rabbits (Oryctolagus cuniculus Linnaeus, 1758), known as low cholesterol meat, can be alternatively chosen for daily consumption. Soybean meal (SBM), as the primary protein source in rabbit ration, has some disadvantages. Protein value in Black Soldier Fly Larvae -BSFL (Hermetia illucens Linnaeus, 1758) is equal to SBM and better in the amino acid profile. However, the chitin contained in BSLF may...
Juliet N. Ozioko1, Obinna V. Ayogu2, Benjamin O. Ezema1, Dilibe C. Uramah3 and Kingsley O. Omeje*,1
...elet index implicated in cardiovascular ailments was lowered after consumption of the leaf extract of C. albidum. The liver marker enzymes aspartate transaminase and alanine transaminase showed no significant changes in their serum activity. Similarly, superoxide dismutase and catalase showed no significant increase after the period of study....
Rafiqul Islam1, Nasrin Sultana1*, Md. Abu Hadi Noor Ali Khan2
...rexposure can harm adult cardiovascular health. Dexamethasone (DEX) is a widely administered synthetic glucocorticoid. The focus of this study was determining how DEX affects serum biochemistry (cholesterol and triglycerides), morphology, and morphometry of broiler hearts. Eighty one-day-old chicks (DOCs) were randomly categorized into four groups i.e., one control group and three trial groups (i.e., E1, E2, and E3). The control group was given commercial broi...
Tao Ren1, Guiqiu Cao2, Xiao Han3, Feng Tan1, Qiaoli Chen4, Shicheng Yang5 and Haiyan Zhang6*
...HD) is a common multiple cardiovascular disease (CVD) in clinical settings. It is a major contributor to mortality and morbidity worldwide and causes a serious threat to human life and health. Naringenin, a flavonoid possesses the potent antioxidant potential and it is proposed to be useful in the treatment of CVD. In this experimental study, we aimed to scrutinize the cardio-protective effect of naringenin against the I/R induced myocardial injury and elucida...
Chinar Mustafa Mohammed1*, Thamer M. Bashir1, Omar A.M. Al-Habib2, Farhad Ramadhan1, Mohammed Bassam1
...taurine, on behavior and cardiovascular function in the male rat following arrhythmia induced by the social stressor. Here, we studied levels of heart electrical activity following experimental conditions: Cage control, social isolation in standard rat housing for 14 days, and pharmacokinetics effect of intravenous administration of different doses of taurine on arrhythmia induced by social isolation in vivo after. The ECG signals and parameters were recorded ...
Muneeza Zafar1,2,3, Fazli Rabbi Awan2,*, Munazza Raza Mirza3,*, Sumaira Nishat2,4, Sajid Ali Rajput5 and Imran Riaz Malik1,*
...ion studies in cohort of cardiovascular patients. While their structural impact on APOB may suggest these predicted nsSNPs possibly be a better drug target and contribute to the treatment and better understanding of human cardiovascular disease....
Zahra Hussain, Zulfiqar Ali* and Rida Ahmad
...testinal issues 17%, and cardiovascular issues 7%. In animals, out of total 102 different diseases and pathological conditions, the maximum variation was noted in mouflon sheep (Ovis orientalis orientalis), hog deer (Axis porcinus) and spotted deer (Axis axis). In birds, 37% infectious diseases, 24% generalized conditions, 15% gastrointestinal and 9% respiratory issues were recorded. Among infectious diseases, salmonellosis, infectious coryza and colibacillosi...
Muhammad Akram1*, Muhammad Imtiaz Shafiq2, Amber Malik3, Farmanullah Khan4, Munir Ahmad Bhinder5 and Muhammad Sajjad6
Aysam Fayed1, Mohga A Ibrahem2, Soha A. Hassan3, Mohammed Abdalla Hussein4*, Tamer Roshdy1
...rs like Type 2 diabetes, cardiovascular disease, and several types of cancer has made obesity a challenge for world health. The current study’s objective was to assess the antioxidant capacity of cranberry extract in high-fat diet-induced obesity. For eight weeks, 36 white albino rats weighing 197±10 g were selected at random to five groups: Group I was administered a regular diet; Group II was fed a high-fat diet; Group III was given a high-fat d...
Ashira Manzoor1, Imran Ahmad Khan1,2*, Muqadas Sadiq3, Muhammad Omer Iqbal4 and Shaukat Hussain Munawar5
...ine for the treatment of cardiovascular disorders....
Samina Kausar1, Rana Badar Aziz2, Muhammad Waseem3, Muhammad Ahmad3, Hamza Shafiq4, Muhammad Asim5, Usama Zia6, Sobia Afzal7, Wanpeng Xi8*, Mansoor Hameed1* and Muhammad Usman Shoukat9
...d lowering the chance of cardiovascular illnesses or cancer. The tremendous results of carotenoids in human food have prompted numerous efforts in plant genetic engineering to supply products with greater carotenoid accumulation, which isn’t always only beneficial for agriculture but also has consequences for scientific research in terms of organic, chemical, and molecular or genetic regulation. Carotenoid metabolism and its regulatory network is not onl...
Chattida Panprom1, Nakrob Pattanapon1, Wannisa Meepoo1, Soontaree Petchdee2*
...erse events and preserve cardiovascular functions. This case report provides recommendations for anesthetic protocols and management in dogs with valvular heart disease. This study suggested that the anesthetic drug protocol of alfaxalone 2.5 mg/kg and a maintenance fluid rate of 5 mL/kg/hr in dogs with valve disease is safe and appropriate for preserving cardiovascular functions.
Keywords | Dog, Gener...
Ghulam Akbar1*, Muhammad Anjum Zia1, Amer Jamil1 and Faiz Ahmad Joyia2
... The mortality rate with cardiovascular diseases is 85% in less developed countries and 75% prevalence is in women. The wild and mutant strains of Streptococcus mutans were used for this trace element optimization study. There are some salts like KH2PO4, K2HPO4, NaHCO3, CaCO3, CH3COONa.3H2O and FeSO4. 7H2O have been optimized for the production of SK. The K2HPO4 has shown the highest enzymatic activity with UV-Et mutant 680.0 UmL-1 and with CaCO3 UV-Et mutant ...
Mian Shamas Murtaza1,*, Aysha Sameen2, Saima Rafique3, Muhammad Shahbaz1,*, Nabeela Gulzar4, Mian Anjum Murtaza5, Umar Farooq1 and Iram Hafiz6
...e hypertension, obesity, cardiovascular diseases etc. Inulin is a food ingredient that belongs to a class of carbohydrates known as fructans with degree of polymerization range from 2-70. Resistant starch is obtained by chemical and enzymatic treatment of starch to increase its properties. These have functional and health-promoting properties as they reduce caloric value, add dietary fiber and endorse prebiotic effects. These are frequently used in industriall...
MUHAMMAD MUNEEB SOHAIL1, FATIMA AMEER2, GUR CHARN SINGH2, MUHAMMAD ZAID1*
...ilia, diabetes mellitus, cardiovascular disease (CVD), cancer, or anemia were excluded from this study. Statistically significant and non-significant results were obtained for different lipoprotein fractions. Although, Body Mass Index (BMI) was a good classical indicator of obesity, other indicators like A Body Shape Index (ABSI) and Body Roundness Index (BRI), also proved significant in assessing the type and severity of dyslipidemia. Different lipoprotein fr...
Amr N. El-Shahat1*, A.M. Abdul Azeem1 and Mohamed H.M. Abd el Megid2
...tivity and prevention of cardiovascular diseases. The present study aims to investigate the effectiveness of bay leaf extract (BLE) in protection against high cholesterol diet (HCD) induced hypercholesterolemia. About thirteen compounds of essential oils were identified by GC/MS analysis including 1.8-cineole, Linalool and sabinene which represent the main volatile oils of bay leaf. Supplementation of BLE with HCD for 10 weeks resulted in reduction in the leve...
Asifa Majeed*, Amir Rashid, Palvasha Waheed, Asma Faryal, Aden Razaq and Ayesha Maryam
... risk factors to develop cardiovascular diseases. The genetic predisposition in association with environmental and lifestyle modifications can play a central role in the progression of diabetic dyslipidemia. A cross-sectional study was designed to detect pathogenic genetic variants in APOA1 and ABCG1 genes associated with dyslipidemia in type 2 diabetic patients. A total of ninety subjects of both genders, aged between 30-70 years were randomly selected ...
Haiyan Nan, Ran Feng, Guiling Zhang and Jingqin Liu*
...ing accurate warning for cardiovascular abnormalities in patients with vascular disease and T2DM....
Rehana Shahida1, Shagufta Naz1*, Tasnim Farasat1, Saima Sharif1, Shah Jahan2 and Farkhanda Manzoor1
... risk of atherosclerotic cardiovascular disease. The development and outcome of atherosclerosis are both influenced by vascular inflammation. The main purpose of this study is to find the impact of Interleukin-6 (IL-6) and thrombomodulin on vascular damage in the patients having impaired glucose tolerance (IGT) and to identify the relationship of IL-6 with insulin resistance. The patients visiting Amin Hayat Memorial Diabetic Center, Lahore from (January 2017 ...
Iqra Munir*, Farrah Iftikhar, Hira Fatima, Sunbal Khalil Chaudhari and Roha Ramash
... 30% plants used to cure cardiovascular diseases and ulcers. The purpose of this study is to recognize wild plants gathered for medicinal purposes by the local residents of Mandi Bahauddin and to document the common names and therapeutic uses associated with these plants....
Hayder S. Rwayyih*, Tahani S.S. Al-Azawi
...acid has a protection on cardiovascular system in menopause estrogen deficiency and ovariectomized female rabbits. Alpha lipoic acid could fight the deleterious effect of menopause estrogen deficiency.
Keywords | Ovariectomy, Menopause, Estrogen deficiency Alpha lipoic acid, Cardiovascular system, Rabbits, Histology, Biological markers
... 
Sri Purwanti1*, Wempie Pakiding1, Marhamah Nadir1, Nurhayu2, Kusumandari Indah Prahesti1, Sitti Nurani Sirajuddin1, Jasmal Ahmari Syamsu1,4, Andi Mushawwir3
...both of which affect the cardiovascular function and energy metabolism in chickens. This research aims to determine the value of lipid regulation and cardiovascular biomarkers of native chickens given a combination of maggot, indigofera and turmeric. A total of 120, 4-week-old male indigenous native chickens with an average initial weight of 42-45 g were divided into 3 treatment groups and fed diets, namely P0 (basal feed), ...
Kingsley O. Omeje1, Juliet N. Ozioko2, Amaechi L. Ogara2, Benjamin O. Ezema2* and Dilibe C. Urama3
...predispose the animal to cardiovascular diseases....
Ghodrat Akhavan Akbari1, Saman Hayadokht1, Saeed Sadeghiyeh Ahari2 and Ahmad Gasi1*
...overy time and worsening cardiovascular system is important and necessary. The main objective of the present study was to evaluate the efficiency of Meperidine and Oxycodone in preventing shivering in patients who underwent inguinal hernia repair with spinal anesthesia. The present study consisted of patients with herniorrhaphy in the Fatemi and Imam Hospital of Ardabil who were studied through a double-blind clinical trial. with spinal anesthesia from 2017 th...
Roy Sukbir Singh1, Jekson Martiar Siahaan2,3*, Endy Juli Anto4, Syafruddin Ilyas5, Putri Eyanoer6, Hendrika Andriani7,8
...lem that is connected to cardiovascular events. It is characterized by disruptions in lipid profiles and is frequently accompanied by endothelial dysfunction, oxidative stress, and inflammation. Aloe vera, renowned for its secondary metabolites, is suggested as a potential treatment because of its hypolipidemic, antioxidant, and anti-inflammatory qualities. This study employed both in-silico and in-vivo approaches to explore these effects. The in-silico analys...
Mehak Muhammad Ashfaq1*, Aqsa Naeem Chawla1, Muhammad Umaid Ali1 and Adnan Ahmed Bhutto2
... a lower risk of cancer, cardiovascular disease (CVD), and other neurological conditions, including Alzheimer’s, Parkinson’s, and others. Nevertheless, due to research constraints and confounding variables such as study design, population size, and usage of various chocolate product types, dosages, and contents, additional large-scale human experiments are required to validate and advocate the chocolate diet. An increasing amount of research shows ...
Eman Wahsh1, Tarek M Ibrahim2, Mirna E. ElAwady3*
...ddicting properties. The cardiovascular drugs, calcium channel-blocker (CCB), nifedipine, and beta-blocker, propranolol, are currently investigated for their possible anxiolytic effects. Anxiolytic properties of CCBs are attributed to inhibition of brain calcium transportation. Propranolol reduces the physical signs of anxiety by blocking adrenergic neurotransmitters. Currently, Vogel conflict paradigm was applied to measure anxiety and validated by using anxi...
