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Clinico-Biochemical Effects of Xylazine-Ketamine and Isoflurane on Rabbits Undergoing Ovariohysterectomy

Clinico-Biochemical Effects of Xylazine-Ketamine and Isoflurane on Rabbits Undergoing Ovariohysterectomy

Muhammad Kashif Maan1, Muhammad Arif Khan1, Shehla Gul Bokhari1, Muhammad Ijaz2, Hamid Akbar1, Sajid Umar 3 and Muhammad Luqman Sohail4,*

1Surgery Section, Department of Clinical Medicine and Surgery, University of Veterinary and Animal Sciences, Lahore
2Medicine Section, Department of Clinical Medicine and Surgery, University of Veterinary and Animal Sciences, Lahore 
3Department of Pathobiology, PMAS Arid Agriculture University, Rawalpindi
4University College of Veterinary and Animal Sciences, The Islamia University of Bahawalpur, Bahawalpur

*     Corresponding author: vet.luqman@gmail.com

 

ABSTRACT

The serum biochemical and cardiovascular effects of total intravenous anesthesia, xylzine-ketamine and inhalation anesthesia, isoflurane was clinically compared in healthy female rabbits (n=16) undergoing ovariohysterectomy. One group of 8 rabbits was anesthetized with combination of xylazine (3mg/kg) and ketamine (10mg/kg, I/V), while the second group (n=8) was pre-anesthetized with xylazine, followed by treatment with isoflurane (4%) with oxygen flow rate of 1L/min. Rabbits administered with xylazine-ketamine anesthesia showed significant increase (P<0.05) in serum alanine aminotrasferase, aspartate transaminase and blood urea nitrogen as compared to isoflurane anesthesia; whereas, no statistical difference (P>0.05) was observed for alkaline phosphatase, creatinine and bilirubin between the two groups. Heart rate, blood pressure and saturation of oxygen were decreased in both groups but this decline was significantly lesser (P<0.05) in isoflurane administered group compared to xylazine-ketamine administered group. Both xylazine-ketamine and isoflurane proved to be suitable anesthetic agents for successful ovariohysterectomy in rabbits. As injectable anesthesia caused significant effect on serum biochemical and cardiovascular parameters when compared to inhalation, so, it is a less safe choice during lengthy surgical procedures like ovariohysterectomy.
 

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Pakistan Journal of Zoology

June

Vol. 53, Iss. 3, Pages 801-1200

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