Xingdong Yang and Lijuan Yuan
...e animal species for the modeling of human enteric pathogen infections, immune responses and for vaccine evaluations. These are the basis for the successful establishment of the infection and disease models for human rotavirus, human norovirus and human enterovirus 71 using neonatal gnotobiotic pigs. The differences between germ-free and normal animals in the maturation status of immune systems caused by the lack of gut microbiota can be minimized by establish...
Xiangxing Zhu1, Junyu Nie1, Shouneng Quan1,2, Huiyan Xu1, Xiaogan Yang1, Yangqing Lu1, Kehuan Lu1 and Shengsheng Lu1*
...w exciting potential for modeling human CNS diseases due to similarities in body size, anatomy, life span, CNS structure and neurobiology. Previously, via the somatic cell nuclear transfer technique, we successfully generated transgenic Guangxi Bama mini-pigs carrying a fluorescent protein (DsRed) reporter gene regulated by the 2.2-kb human glial fibrillary acidic protein promoter (hGFAP-DsRed). This study characterized transgene expression in such transgenic ...
Abdul Baset1, Qun Liu1,*, Muhammad Tariq Hanif1, 2, Baochao Liao1, Aamir Mahmood Memon1,3 and Muhammad Mohsin1
Muhammad Mohsin Raza*, Muhammad Aslam Khan*, Irfan Ahmad**, Ali Ahsan Bajwa***, Hafiz Muhammad Usman Aslam*, Badar Ahsan Ullah****, and Kashif Riaz*
FOREST PATHOGENS AND DISEASES UNDER CHANGING CLIMATE -A REVIEW
...ategies like monitoring, modeling prediction, risk rating, planning, genetic diversity and facilitated migration, genetic protection and breeding for disease resistance and relating results to forest policy, planning as well as decision making, the suspicions innate to climate change effects can be minimized....
Musrrat Fatima, Muhammad Saad Khan, Hamid Rashid, Asim Mehmood, Sumaira Kanwal, Muhammad Asif Rasheed and Farrukh Jamil*
...e used for pharmacophore modeling, and Zinc natural compounds database (ZND) is screened against the developed pharmacophore. The compounds with the highest pharmacophore fit scores are screened and docked on the identified allosteric site of NS2B-NS3. Analysis of the data showed two compounds (ZINC00845171, ZINC08782519)as potential inhibitors for NS2B-NS3 of ZIKV.
...
Wasim Javaid1, Farid Asif Shaheen1*, Farah Naz2 and Muhammad Usman Raja2
Fouzia Hadi Ali1, Farhat Naz2, Aban Abid Qazi3
Tianlong Cai1, Falk Huettmann2, Kisup Lee3 and Yumin Guo1,*
...Asia. A machine learning modeling algorithm of maximum entropy (MaxEnt) weas applied and evaluated with Stochastic Gradient Boosting and Random Forests based on 115 every year used occurrence points (1990-2013) and 14 environmental layers as predictors. Results show that the Songnen Plain and Korea Peninsula are the most important stopover habitats. Four other major areas are also suitable for stopover: (i) the coastal area of the Bohai Sea, (ii) the Three Riv...
Iftikhar Ud Din* and Qamruz Zaman
...s achieved when we shift modeling approach from classical linear regression (CLRM) to multilevel modeling. The study also discussed an important problem in Multilevel Modeling (MLM) i.e. to find sufficient sample size for accurate estimation purposes. In MLM, apart from the general factors of sample size estimation, the test size, the effect size, SE (standard error) of the effect size and...
Hafiza Sadaf Zahra1, Asia Iqbal2, Sayyeda Hira Hassan1, Hafiz Abdullah Shakir1*, Muhammad Khan1*, Muhammad Irfan3, Chaman Ara1, Shaukat Ali4
...ion through epigenetic remodeling by DNA methylation and histone acetylation.
...
Asim Faraz1*, Abdul Waheed1, Muhammad Mudasser Nazir2, Aneela Hameed3, Nasir Ali Tauqir4, Riaz Hussain Mirza1, Hafiz Muhammad Ishaq1, Rana Muhammad Bilal5
...hrough effects on cell remodeling. Observed effects of OT administration on reproductive anomalies are anestrous, the development of corpus-luteum cysts, follicular ovarian cysts, delayed age at puberty, repeated estrous cycles, dystocia, abortions, dead fetuses and retention of the fetal membranes. OT administered exogenously or secreted endogenously, establishes in minutes the desired effects and metabolized to inactive products rapidly in the body. Irrespec...
Application of MATLAB for Designing and Simulation of High-Efficiency Center Pivot Irrigation System
Filza Fatima Rizvi1*, Waqar khan2, Syed Mohsin Raza Kazmi3 and Muhammad Umer4
...ndly software for linear modeling. The simulation showed 99 % accurate results as the actual readings, e.g. the actual flow rate calculated at the field was 274 GPM while the designed value was 276.76 GPM. The designed total dynamic head was 110.34 feet, while the actual in the field was 108 feet. Through linear modeling, we can get our desired results very quickly and easily by adjusting our input parameters. Such a
Mujahid Khan1*, Mohammad Tufail2, Muhammad Fahad1, Hazi Muhammad Azmathullah3, Muhammad Sagheer Aslam1, Fayaz Ahmad Khan4, Asif Khan5
EXPERIMENTAL ANALYSIS OF BRIDGE PIER SCOUR PATTERN
...onducted in the physical modeling laboratory of River Engineering and drainage control, USM, Malaysia.
The study shows that the pier scour depth and affected area around pier increase with the increase in pier size.
The study further demonstrates that the square pier models results in greater scour depth and area as compared to
circular pier models. Magnitudes of scour depths and area with reference to variation in shapes and sizes of pier...
The study shows that the pier scour depth and affected area around pier increase with the increase in pier size.
The study further demonstrates that the square pier models results in greater scour depth and area as compared to
circular pier models. Magnitudes of scour depths and area with reference to variation in shapes and sizes of pier...
Zulfiqar Ali Soomro1*
NOISE CONTROL FILTRATION OF LATERAL AND YAW DYNAMICS FOR RAILWAY VEHICLE WHEELSET ON TRACK
...sed framed for necessary modeling. The estimation
of perturbations for the movement by wheels and velocity of train in lateral and yaw phases are enumerated.
Here dual bucy kalman estimator is implemented to decrease the influence of the noise caused due improper ratio
of adhesion level upon track. One estimator reduces the overshoot of noise and other to minimize it at lower level
of level of error. Further the behavior of lateral ...
of perturbations for the movement by wheels and velocity of train in lateral and yaw phases are enumerated.
Here dual bucy kalman estimator is implemented to decrease the influence of the noise caused due improper ratio
of adhesion level upon track. One estimator reduces the overshoot of noise and other to minimize it at lower level
of level of error. Further the behavior of lateral ...
Samreen Fatima1*, Mudassir Uddin1
COMPARISON OF ASYMMETRIC GARCH MODELS WITH ARTIFICIAL NEURAL NETWORK FOR STOCK MARKETS PREDICTION, A CASE STUDY
...forts have been done for modeling of financial data theoretically and empirically for the international
stock markets, for example: Asia, Europe and Australia etc. But no frequent research has been done for the SAARC
countries stock markets. Therefore, bench mark Index of Pakistan; Karachi Stock Exchange (KSE-100) and Bombay
Stock Exchange (BSNSE) of India are selected as case study. They are not only the member of SAARC but also sharing
stock markets, for example: Asia, Europe and Australia etc. But no frequent research has been done for the SAARC
countries stock markets. Therefore, bench mark Index of Pakistan; Karachi Stock Exchange (KSE-100) and Bombay
Stock Exchange (BSNSE) of India are selected as case study. They are not only the member of SAARC but also sharing
Muhammad Imran Ahmad*, Nan Zhang**, Megan Jobson**, Muhammad Younas*, Kamran Ghani***
DELUMPING PROCEDURE FOR PREDICTION OF DISTRIBUTION OF PRODUCTS IN DISTILLATION USING A SHORT-CUT MODEL
... the application in modeling of distillation using short-cut calculation methods. The proposed methodology helps retain molecular information of composition of petroleum fractions and may help extend the premise of molecular components-based modeling to separation processes such as distillation.
...
Usman Ali Naeem*, Hashim Nisar*, Habib-ur-Rehman** and Naeem Ejaz*
DEVELOPMENT OF FLOOD DISCHARGE MODELS USING GIS
...cerned departments, modeling and predictions of futuristic results is possible which will yield better decision making leading to fructifying outcome. Physical hydrologic models for drainage areas are significant utensils to hold water assets management and foresee diverse hydrologic contacts and risks. Indus River is considered as salvation of Pakistan and it is also the largest river of the country. The approximate length of the river is ...
Arshad Habib Malik*, Aftab Ahmed Memon** and Muhammad Rafiq Khan***
DYNAMIC MODELING AND CONTROLLER DESIGN FOR NUCLEAR POWER PLANT
...igher order mathematical modeling and discrete fast output sampling control synthesis for PHWR (Pressurized Heavy Water Reactor)-type nuclear power plant is presented in this paper. The nonlinear dynamic model of PHWR power reactor is developed based on reactor, logarithmic amplifier, moderator level control valve and reactivity system. The nonlinear model is characterized by 15 state variables and one input. This higher order nonlinear mod...
Samet Hasan Abaci1,*, Hasan Onder1, Mustafa Sahin2 and Esra Yavuz3
...mal breeding. Therefore, modeling lactation curves with appropriate and precise equations are of great importance for obtaining estimates. Lactation curves have different tendencies in different breeds. To examine the tendencies and differences Jersey (J), Brown Swiss (BS) and Holstein Friesian (HF) breeds which are commonly raised in Turkey were used in this study. This study aimed to statistically determine the optimal position and number of knots in cubic s...
Yuan Xing, Congming Tan, Yan Luo and Wenjun Liu*
...nced, ultra-structural remodeling, and airway mucus production. The current experimental study was aimed at scrutinizing quercetin’s inhibitory effect on airway inflammation in mice and its possible mechanism of action. The mice received varying doses of quercetin from 22-30 days (1, 10 and 50 mg / kg, p.o.) and montelukast (10 mg / kg, p.o.). Intranasal OVA has been instilled on the 21 days. Biochemical parameters, spleen weight, physiological parameter...
Minghao Gong1*, Shiliang Pang2, Zhongyan Gao2, Wanyu Wen1, Ling Zhang3, Gang Liu1, Huixin Li1, Fawen Qian4 and Wenfeng Wang2
...ulation Models in Maxent modeling to project changes, including suitability and fragmentation, in RCC breeding habitat up to the year 2050. Based on climate change, we predicted a decline in 2050 of suitable and sub-suitable habitat from the current 26.2% to 14.3%-19.7% in the study area, but an even larger loss (from 71.3% to 27.3%-32%) of suitable habitat in Zhalong Reserve. The predictions also showed a northward movement of RCC habitat and a loss of curren...
Shakeel Ahmed Soomro1,2, Sikandar Almani3, Lal Bux4, Khalil Ahmed Ibupoto2, Muhammad Sohail Memon2, Farman Ali Chandio2, Shakeel Hussain Chattha2, Zaheer Ahmed Khan2, Zubair Ahmed Soomro5,Babar Mustafa Ansari6 and Kunjie Chen1*
Amreen Zahra1, Mushtaq A. Saleem1*, Hasnain Javed2, Muhammad Azmat Ullah Khan3, Muhammad Naveed1 and Abdul Rauf Shakoori4
...ol proteins by molecular modeling approaches. Mutational analysis in our study revealed S61A, S61M, S61Y, S61G, S61Q and M90L as the most hypervirulent mutations. This induces a selection pressure and a rate of increased virulency on Gag-Pol cleavage sites. These results significantly highlight the fact that the identified SNPs possibly contribute towards a positive selection pressure contributing to the identification of novel mutations like S61A, S61M and M9...
Experimental and Numerical Assessment of Masonry Infill on Seismic Performance of RC Frame Structure
Syed Azmat Ali Shah1*, Asfandyar Ahmed2, Khan Shahzada3, Syed Muhammad Ali4, Akhtar Naeem Khan5 and Akhter Gul6
...ntal tests and numerical modeling were performed, and the results compared show a good relationship. The analysis results match very well with the experimental observations. For numerical modeling of the infill wall, a modified micro-modelling approach is selected where the head and bed joints are lumped into the bricks and an interface model was defined between these bricks representing the behavior of the mortar joint. App...
Bambang Yudi Ariadi1*, Rahayu Relawati1, Barbara Szymoniuk2 and Waris Ali Khan3
...dash;structural equation modeling (PLS-SEM) model. The results revealed that product, psychography, and demography influence the purchase of organic vegetables. Furthermore, product and demography also influence the WTP of organic vegetables. All product attributes positively correlate with product variables, except the label. About psychography, consumers’ concern regarding the environment is more critical than health motivation, primarily in influencin...
Tao Ren1, Guiqiu Cao2, Xiao Han3, Feng Tan1, Qiaoli Chen4, Shicheng Yang5 and Haiyan Zhang6*
...at I/R induced cardiac remodeling can be successfully mitigated by naringenin....
Xiaojing Liu and Zhongxin Li*
...red with those in the DN modeling group, 24 h urine protein, serum creatinine (Scr), blood urea nitrogen (BUN), blood uric acid (UA), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) significantly reduced in rats treated with TSG (20 mg/kg) (P<0.05), blood total protein (TP) and albumin (ALB) significantly increased (P<0.05), VEGF expression significantly reduced (P<0.05) and MMP-9 expression significantly increased (P <0.05). Th...
Mohammed A. Almujtaba1, Turky Omar Asar2, Salma Naqvi3, Vikas Kumar4, Fahad A. Al-Abbasi1, Abdulbasit I. Al-Sieni1 and Firoz Anwar1*
...ubicin induced cardiac remodeling in rats. Male Wistar albino rats were divided into 4 groups (n=6) for 28 days of experimental protocol. Group-1 served as normal control (NC), group 2 as doxorubicin control (DC), group 3 as doxorubicin+ Zamzam treatment (DZ) and group 4 as Zamzam control (ZZ). Doxorubicin (1mg/ kg bw) was injected i.p. in DC and DZ groups on first day of study. NC and DC groups were at normal bottled water p.o., while DZ and ZZ groups receive...
Zheng-Yong Wen1, 2*, Chuan-Jie Qin1,2, Bin Li1,2, Rui Li1,2 and Xiao-Tao Shi3*
...mensional (3D) structure modeling revealed that pvLeptin was highly conserved with that of other tetrapods. Genetic synteny analysis revealed that lepB had specifically lost in siluriformes teleosts. Phylogenetic analysis showed that fish lineage contained two clades of leptinA and leptinB, and the pvleptin was grouped into leptinA clade and shared a close relationship with its counterpart in P. fulvidraco. Tissue distribution analysis showed that pvleptin was...
Eighty Mardiyan Kurniawati1*, Budi Santoso1, Fedik Abdul Rantam2, Widjiati3, Budi Iman Santoso4, Tri Hastono Setyo Hadi1, Gatut Hardianto1, Hari Paraton1
...issue structure in the remodeling phase of the vesicovaginal fistula between the use of freeze-dried amnion and primary suturing on day 21. Materials and Methods: This experimental study used New Zealand rabbits which were female and weighed 3-4.5 kg. The first stage of the study created a model of a vesicovaginal fistula. The second stage of the study closed the vesicovaginal fistula which was successfully created in the first stage. The study used a post-tes...
Yar Muhammad Jalbani1,2*, Muhammad Farooque Hassan2, Kiran Nazish2 and Yang Shuming1
... driven soft independent modeling of class analogy. The meat samples from day 0 were selected as target class and checked against other day samples. All the samples were accepted for training data set with 4 PCs while for test data set the constructed model accepted 100% samples and 100% rejection for other day samples. Three PCs were depicted for target class 3 and model accepted all the training samples, while for test set samples, the rejection ratio for Da...
Hongfeng Guo
...h continuous CPAP during modeling. The expressions of malondialdehyde (MDA), superoxide dismutase (SOD) and prostaglandin (PGE) in lower respiratory tract were detected by the kit; the expressions ofprotein kinase B (Akt), Bax and Bcl-2 were detected by Western blot. According to our findings after drug treatment, the body weight and respiratory ventilation of mice returned to normal level compared with the intermittent hypoxia group. Compared with the blank c...
S. Anwar1, K. Wieczorek1 and E. Inselsbacher2 †
...door to understand the remodeling of amino acid metabolism in response to H. schachtii infection in plants....
Usman Ali1,2*, Basharat Ahmad1, Riaz Aziz Minhas1, Muhammad Kabir3, Muhammad Siddique Awan1, Liaqat Ali Khan1 and Muhammad Bashir Khan1
Siswanto Imam Santoso*, Agus Setiadi, Wahyu Dyah Prastiwi
...ity. Structural equation modeling (SEM) using TETRAD-IV software was employed to establish the analytical model. The results show that duck farming is sustainable regarding social, economic, and environmental aspects. Medical and technological factors significantly affect production. Social factors, egg processing, technology, and production significantly affect sustainability. To improve the sustainability of duck farming, it is necessary to increase the role...
Mohammad Bani Ismail
...">Pathological cardiac remodeling can lead to heart failure and cardiac hypertrophy. Zizyphus jujuba var spinosa seeds contain SPN, a C-glycoside flavonoid used in traditional medicine. A growing body of evidence indicates they have pharmacological potential against a wide range of diseases. Spinosin (SPN), however, has not been examined in relation to doxorubicin (Dox) induced cardiac injuries. To find out if SPN can reverse Dox-induced cardiomyopathies, we c...
Burarah Arooj1, Zeeshan Mutahir1, Moazzam Ali1, Mohsina Akhter2, Malik Siddique Mahmood1, Arslan Hamid3 and Mahjabeen Saleem1*
Yanmei Wang1,2, Haoyun Li1, Lijuan Han1 and Wenkui Wang1*
...monary artery vascular remodeling, and lead to PH. This study aims to provide theoretical basis for finding new therapeutic targets for broiler PH....
Romaan Hayat Khattak1, Shakeel Ahmed2, Liwei Teng1,3* and Zhensheng Liu1,3*
... We used maximum entropy modeling (MaxEnt) to identify suitable habitats for red fox (Vulpes vulpes) in Nowshera district, Pakistan. MaxEnt was applied to 62 red fox occurrence points and topographical and current bioclimatic variables. The receiver operating characteristic (ROC) values obtained in the present study, i.e., the area under the curve (AUC: 0.828), showed that the results were good and valuable. Of the total area studied (1747 km2), 272 km2 (20.15...
...mum entropy distribution modeling was used for predicting potential suitable habitat for gummy bark disease in Egypt using occurrence records. The Maxent model's internal jackknife test Of variable importance showed that altitude and mean temperature of driest quarter are the most important predictors of citrus gummy bark disease-habitat distribution....
MUHAMMAD JAVAID AFZAL*1, FARAH JAVAID2, MUHAMMAD WASEEM ASHRAF3, SHAHZADI TAYYABA4, MAMOONA ASHIQ5 & AYESHA AKHTAR5
...gic deliver an effective modeling presentation by showing good agreement with the parametric measurements. Therefore, Fuzzy Logic is an alternate method to obtain outflow rate and other parameters for nanoneedles. This nanoneedle technology is revealed as a dominant and multipurpose technology. It can deal with many new customs to discover biomedical procedures with new bio-physical characteristics of the living cells....
