Mudasir Irfan Dar*, Fareed Ahmad Khan and Farha Rehman
E-mail | [email protected]
...ed increasing trend in a dose-dependent manner, attaining maximum at 40 g.a.i ha-1 of Imidacloprid treatment at day 7 after treatment (DAT) followed by 3 and 15 DAT, respectively. On the contrary, the CAT activity was increased at lower concentrations of Imida- cloprid but showed a dose dependence decline at higher concentrations of the insecticide at all the observed growth stages, with maximum decrease under 40 g.a.i ha-1 at 15 DAT followed by 3 and 7 DAT re...
Xiaqing Chen, Yü Huang and Zhen Huang*
...l growth inhibition in a dose-dependent manner was observed when ethyl acetate extract and carbendazim were applied individually. The EC50 of T. hamatum ethylacetate extract or carbendazim in mycelial growth inhibition of S. shiraiana was 6.6 μg/ml or 39.5 μg/ml under laboratory condition, respectiviely. The level of synergism between ethylacetate extract and carbendazim was affected by the concentration of each component in...
Muhammad Usman Akhtar1,2, Abdul Qayum3, Anshan Shan1,*, Shuli Chou1, Hyeonsoo Jo4, Syed Waqas Ali Shah4 and Ishfaq Muhammad5
...iet has a linear effect (dose-dependently) on nutrient digestibilites, nutrient intake and milk yield. Dry matter (DM), crude protein (CP), neutral detergent fiber (NDF) and acid detergent fiber (ADF) intake were higher (P < 0.05) in goats fed 70RDP diet than those fed 30RDP diet. Nutrients digestibilities (DM, CP, NDF and ADF) were significantly higher (P < 0.05) in goats fed 60RDP diet than those fed 30RDP. Goats fed 70RDP diet produced higher milk yie...
Syeda Farzana Bibi* and Siraj-ud-Din
Fluorescence Analysis, Extractive Values and Cytotoxic Screening of Crataeva adansonii DC Leaf and Bark through Brine Shrimp Larvae Assay
...crude drugs of each part dose-dependently exhibited cytotoxic activity. At higher concentration (100-1000 μg/ml) the leaf and bark ethanolic extracts showed cytotoxicity and at lower concentration (10 μg/ml) very low cytotoxic effect was observed (Figure 4). The LC50 values for crude leaf extract were found to be 5.34 and for that of stem bark extract, it was 7.44 ug/ml. This study manifests that the selected plant can be helpful in t...
Feng-Mei Yang1, Rui Li2, Xiu-Xue Hu3, Yong Liang4, Bo Gao3* and Wei Chen3*
...d promote apoptosis in a dose-dependent and time-dependent manner, and high level as well as prolonged UVB irradiation lead to NHSFs senescence.
...
MA Liman1, QI Yongxiao1, Wang Wenji2* and Zhong Qianyi3*
...m 30 to 84.85 μM in a dose-dependent manner. Moreover, quantitative real-time PCR revealed that G-Rh2 suppressed vascular endothelial growth factor (vegf) mRNA expression but not mRNA expression of its receptors (flt1, kdr). Western blot further confirmed that G-Rh2 treatment resulted in reduced Vegf protein expression. Our study suggested that G-Rh2 may exert anti-angiogenic activity by downregulation of Vegf in zebrafish embryos, thus...
Syeda Farzana Bibi* and Siraj ud Din
Unraveling the Bioherbicidal Potential, Elemental Analysis and Nutritional Evaluation of Crataeva adansonii Dc Leaf and Bark
...t results in the form of dose-dependent inhibition of frond growth. Ethanolic extract of C. adansonii exhibited 30% inhibition at 1000 μl concentration, and at the same concentration, the bark extract inhibited the frond growth by 40%. The pharmacognostic evaluation of this medicinal drug will be supportive in the detection of adulteration and quality control. Due to the herbicidal potential, it can be used in the agricultural industry. For future studies, ...
Yihong Tian, Yongmei Qi*, Sajid Naeem, Ke Gao and Yingmei Zhang*
...ility of Hela cells in a dose-dependent manner in conjunction with disrupted morphology. Moreover, spermidine caused cell damage as evidenced by elevated LDH leakage and compromised MMP as demonstrated by flow cytometry. Concomitantly, western blot analysis showed that spermidine induced autophagy by activating the LC3 conversion and p62 degradation at different concentrations and durations. However, inhibition of autophagy by 3-MA rescued the survival of Hela...
Yujun Zhao and Jianping Fan*
...(p <0.05) in a dose-dependent manner. Hence, this can be concluded that Kanglaite injection can effectively inhibit the proliferation and induce apoptosis of SW480 cells, which may be correlated with the inhibition of Bcl-2 expression, the promotion of Bax expression and the enhancement of caspase activity.
...
Yuan Xing, Congming Tan, Yan Luo and Wenjun Liu*
...gnificantly reduced in a dose-dependent manner through quercetin. Quercetin (P<0.05) significantly reduced the level of TNF-α, IL-1β, IL-4 and IL-5 cytokines and increased the level of IFN-π in allergic asthma mice caused by OVA. In contrast, there was no significant effect in the body weight of mice treated with quercetin. Based on the result, we may infer that quercetin demonstrates an inflammatory mechanism for the therapeutic effect of inf...
Ibadullah Jan1*, Iqbal Munir2, Inamullah Khan3, Syed Muhammad Suhail4 and Aqib Iqbal2
...used by carrageenan in a dose-dependent way, with the highest levels at 40 and 80 mg/kg. Dosiflavone showed excellent (p<0.05) analgesic activity with anti-nociceptive effect in hot plate test in a dose-dependent manner. Dosiflavone showed significant anti-nociceptive activity and decreased the number of writhes instigated by one % ethanoic acid. Dosiflavone dosages (20, 40, and 80 mg/kg) were relative to the placebo, the...
Junli Liu1, Tongfang Yang2 and Lisheng Wu3*
...P<0.05). All were dose-dependent. LINC00857 targets and regulates miR-340. Overexpression of LINC00857 or inhibition of miR-340 evidently reduced the expression levels of P21, Caspase-3 and apoptosis in U2OS cells after homoharringtonine treatment, and remarkably improved cell survival rate and colony formation (P<0.05). It is concluded that homoharringtonine can inhibit the proliferation of osteosarcoma cells and induce apoptosis by regulatin...
Noor Bad Shah Khattak1, Hamayun Khan1, Muhammad Tarique Tunio2, Shakoor Ahmad1, Nazir Ahmad3, Syed Murtaza Hassan Andrabi4, Obaidullah5, Ihsan Ali1,5,* and Nan-Zhu Fang5,*
Nacira Djabali1*, Souad Dougat2, Wahida Haddadi2 and Lamis Fadhli2
...ained show a significant dose-dependent decrease in LH, FSH and testosterone in the treated groups compared to control. The administered solvent caused severe deterioration in sperm quality, decreased sperm concentration, mobility and vitality, with increased sperm morphological malformations. The treated individuals show hypogonadism and severe tissue damage, especially in group treated with 150ppm dose.
... 
Arkan B. Mohammed*, Ammar S. Abdulwahid, Samah M. Raouf
...chemical parameters in a dose-dependent manner.
Keywords | Antioxidants, Egg production, Laying hens, Thyme
El-Kholy KH1, Tag El-Din H1, Tawfeek FA2, Sara HM Hassab1*
..., SLAE addition result a dose-dependent decrease (P<0.05) in ACTH levels in laying hens. The treatment did not affect T4 and LH hormones (p=0.1470 and 0.2764, respectively). Regarding reproductive traits, the treatment increased the hatchability to total and fertilized eggs, maximizing in groups treated with 5 and 7.5 ml SLAE/kg diet. There was a non-significant association between SLAE addition and all reproductive traits, however, SLAE at the dose of 7.5...
Tao Ren1, Guiqiu Cao2, Xiao Han3, Feng Tan1, Qiaoli Chen4, Shicheng Yang5 and Haiyan Zhang6*
Mehroze Amin1, Afifa Yaqub1, Qindeel Fatima1, Rabail Hassan Toor1,3 and Abdul Rauf Shakoori1,2*
...ated p53 expression in a dose-dependent manner, while the expression of interacting partners is downregulated indicating that metformin exhibits the anti-cancerous effect by regulating the p53 pathway. Altogether this study reports the effect of metformin on the expression of p53 and its interacting partners MDM2, PIRH2 and ΔNp73in breast cancer cell line MCF-7, thereby providing evidence that metformin modulates p53 pathway to exhibit its anti-cancer pr...
Afifa Yaqub1, Mehroze Amin1, Qindeel Fatima1, Rabail Hassan Toor1,3, Saira Aftab1 and Abdul Rauf Shakoori1,2*
...ession was observed in a dose-dependent manner in both cell lines with increasing UNC0642 concentrations. A dose-dependent downregulation of gene expression of proliferation marker genes (FGF-1, CCND1, and ENO2) was observed in both cell lines, whereas upregulation of tumor suppressor genes (AMPKα2 and ELL2) and apoptotic marker gene (BIM) was observed in a dose-dependent manner. Tak...
Ashira Manzoor1, Imran Ahmad Khan1,2*, Muqadas Sadiq3, Muhammad Omer Iqbal4 and Shaukat Hussain Munawar5
...ced myocardial damage in dose-dependent manner. The cardiac tissues showed marked improvement in extract treated groups as compared to doxorubicin treated group. This research indicates that the hydro alcoholic leaf extract of C. colocynthis have exceptional cardio protective potential as compared to toxicity induced by DOX. As a result, it could be used as an alternative medicine for the treatment of cardiovascular disorders....
Asmatullah Kaka1*, Wahid Haron2, Nurhusien Yimer3, Abdullah Channo1, Ali Raza Jahejo2, Mahdi Ebrahimi3, Dildar Hussain Kalhoro4
...ed and control groups. A dose-dependent increase (P<0.05) was found in C22:6n-3, DHA and n-3PUFA as compared to control group. In conclusion, supplementation of 10 ng/ml of DHA in a Tris-based extender improves the frozen-thawed quality of bull semen.
Keywords | Docosahexaenoic acid DHA, Fertility, Freezing, Tris-Extender, Spermatozoa.
...
Ahmed Ali Chandio1, Asghar Ali Kamboh1*, Nazar Ali Korejo2, Riaz Ahmed Leghari3 and Muhammad Ali Chandio4
... and gut microflora in a dose-dependent fashion thus suggested its’ inclusion in broilers diet up to 2% level....
Bing Yan1, Meng Meng Zhang2, Xi Chen2, Yongming Li2*, Muhammad Khan3* and Tonghui Ma1*
... glioblastoma cells in a dose-dependent manner. Further mechanistic study showed that ALT inhibits glioma SCLP and tumor growth through repression of EGFR/MOB1/LATS1/YAP signaling pathway. These findings were further validated using in vivo xenograft mouse model. Taken together, the data provides convincing evidence of ALT-mediated inhibition of glioma SCLP and tumor growth via repression of EGFR/MOB1/LATS1/YAP pathway and suggests ALT as a promising therapeut...
Sajida Batool, Iqra Ashraf, Shafaat Yar Khan, Sitara Shameem* and Breha Kazmi
...ls in time-dependent and dose-dependent manner. These findings are suggesting the immunomodulatory potential of methanolic leaf extract obtained from C. procera that together with its other therapeutic properties can be used towards modulating the immune response....
Arslan Muhammad Ali Khan1, Rao Zahid Abbas1*, Zia ud Din Sindhu1, Muhammad Shahid Mahmood2
... rates of mortality in a dose-dependent manner of adult and larvae of Hyalomma spp. Egg number, egg mass, and larval hatching were also reduced significantly (p<0.05) in a dose-dependent manner. As a result, reproductive index (RI), reproductive efficiency index (REI), and nutrient index (NI) were also decreased significantly (p<0.05) in a dose-dependent manner. Similarly, A. subulat...
Rizqan*, Hilda Susanty, Linda Suhartati, Azhar, Arief, Elly Roza
...iffusion test revealed a dose-dependent inhibitory effect of the citrus fruit peel eco-enzyme against both Staphylococcus aureus and Escherichia coli. These findings underscore the antibacterial potential of the citrus fruit peel eco-enzyme solution and suggest its viability as a natural and environmentally friendly teat dipping solution for dairy cattle.
...
...
Waseem Abbas, Imtiaz Ahmed* and Imran Khan
...ldquo;significantly in a dose-dependent manner with the increasing incorporation of these two herbs” when compared with the CB. When the carbohydrate content of both breads was compared, the functional bread had significantly lower values (p, for all trends < 0.05), respectively, as the ratio of incorporation increased. Total starch (TS) and DS reduced non-significantly at 1 and 2 % and significantly at 3% incorporation as compared with CB. Resistant ...
Tianhoun Denté Fidèle1,2*, Meda Nãg-Tiéro Roland2, Zabré Geneviève3, Koama Benjamin2, Kaboré Adama1, Tamboura H. Hamidou1, Bélem Adrien Marie Gaston4
...ent of the parasite in a dose-dependent manner. The inhibitory concentration 50 (IC50) for egg hatching ranged from 2.189 and 2.994 mg/ml for the hydroacetone and aqueous extracts respectively, and that for larval development was 1.970 for the hydroacetone extract and 2.761 mg/ml for the aqueous extract. The addition of polyvinylpolypyrrolidone (PVPP) to the extracts showed that the tannins present were responsible for the bioactivity observed in both plant ex...
Abdelghafour El-Hamzaoui*, Mouloud Lamtai, Laila Ibouzine‑Dine, Sofia Azirar, Mohamed Yassine El-Brouzi, Ayoub Rezqaoui, Aboubaker El-Hessni, Abdelhalem Mesfioui
...ndertaken to examine the dose-dependent impact of GBH exposure over 8-week period on anxiety- and depression-like behaviors in male Wistar rats, administering daily subcutaneous injections of four different doses 25, 50, 75, and 100 mg/kg of GBH while a control group received 0.9% NaCl. Based on behavioral tests (the open field, elevated cross maze, and forced swim), behavioral alterations were detected, specifically anxiety levels and depressive behavior. Sim...
Hala Harifi*, Mouloud Lamtai*, Siham Ait Salhi, Fatima-Zahra Azzaoui, Omar Akhouayri, Abdelhalem Mesfioui, Leila Bikjdaouene
...c exposure to Mn induces dose-dependent toxic effects, as evidenced by the observed clinical signs of toxicity.
Keywords | Manganese, Chronic exposition, Toxicity, Clinical symptom, Dose-dependent, Rat
...
Muhammad Salman1, Rao Zahid Abbas1*, Muhammad Kasib Khan1 and Muhammad Shahid Mahmood2
... The results indicated a dose-dependent effect of C. verum essential oil showing 20% concentration to be the most effective in view of the acaricidal and the repellent activities. Hence, this essential oil can be considered as a potential candidate for the effective control of cattle tick (R. microplus)....
Waqas Ahmad Shams1*, Gauhar Rehman2, Muhammad Ismail3, Rahmul Kabir4 and Abdul Qahar1
...ract showing significant dose-dependent activity. Overall, our findings suggest that both aqueous and ethanolic extracts possess substantial antioxidant potential, warranting further validation through in vivo experiments and clinical trials. This study underscores the promising therapeutic applications of Crab Himalayapotamon emphysetum extracts as natural antioxidants in combating oxidative stress-related diseases.
Bilal Ahmed1, Faheem Ahmed Khan2, Nuruliarizki Shinta Pandupuspitasari1*, Muhammad Rizwan Yousaf1 and Asep Setiaji1
...ble insights into future dose-dependent studies to address the methanogenic potential of yeast-based products recognizing the urgency of identifying effective mitigation strategies while maintaining productivity. As the cattle industry seeks sustainable solutions, further research should explore alternative strategies and optimize interventions for both productivity and environmental sustainability....
Nasr Tarq Mohammed
...strates the significant, dose-dependent anticancer effects of aqueous garlic extract on breast cancer cell lines, highlighting its potential as a promising and accessible therapeutic agent in cancer treatment strategies. ...
Safaa El Bialy1*, Nabil Bker2, Hossam Ibrahim3, Saber, A. Saad4, Eman Ali5
...status, the results were dose-dependent, showing that higher concentrations of PEO, especially 3%, led to greater reduction percentages. The highest reduction, reaching 100%, was observed in the counts of Enterobacteriaceae and coliforms. The study concluded that using parsley essential oils at varying concentrations, particularly at 3%, could extend the shelf life of fish up to 8 days during refrigeration, specifically due to to their antioxidant and antibact...
Abrar ul Haq1, Shusheng Yin2, Amara Maryam1, Muhammad Khan1*, Hafiz Abdullah Shakir1, Muhammad Akhtar Ali3, Muhammad Irfan4, Muhammad Faisal Maqbool1 and Yongming Li2*
...stant Hey-T30 cells in a dose-dependent fashion. Using Molecular docking study, we found that lathyrol exhibits strong binding interactions with STAT3 DNA binding domain through hydrogen bonding and hydrophobic interactions with various amino acid residues of STAT3. Using immunoblotting, we found that lathyrol did not inhibit STAT3 phosphorylation and dimerization. Moreover, we showed that lathyrol induces apoptosis as evident from a remarkably increased expre...
