Antimicrobial Evaluation of Different Types of Aurantioideae Extracts Against Some Pathogenic Bacteria
Antimicrobial Evaluation of Different Types of Aurantioideae Extracts Against Some Pathogenic Bacteria
Orooba Mohammed Saeed Ibrahim1*, Rawaa Saladdin Jumaa2, Nibras Zeyad Yahya1
ABSTRACT
The antimicrobial resistance phenomenon has recently emerged as the major public health problems, and efforts to create new medication to counter bacterial infections. Consequently, there is a gap in the market for novel adjuvants. The primary initial source of many medicines used to treat diseases today was plants. This study aims to ascertain the antibacterial activities of fruit Citrus aurantium and Citrus limonum juice on isolated Staphylococcus aureus, Sterptococcus pneumoniae and Klebsiella pneumonia. The antibacterial activity of fruit juice extract on bacterial strain was determined using macro-broth dilution, agar well diffusion methods and time kill curve. Results revealed that the used juice extracts were variously bacteriostatic and bactericidal against the examined bacteria depending on concentration. Phytochemicals analysis indicated the presence of alkaloids, phenol, saponins, flavonoids, tannins, and glycosides. The test organism was more sensitive to C. limonum compared to C. aurantium. The MICs ranged from 1.56 to 12.5mg/ml; MBCs, (3.125 - 25mg/ml) and MBC/MIC ratios (2.0-4.0). Furthermore, a time killing curve of each 4x MICs and 8x MICs concentrations of juice extract showed a distinguished bactericidal effect at 6th hr. Therefore, the use of citrus fruit juice as medicine to treat infections is supported scientifically by these findings.
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