Huma Naz1*, Sajid Abdullah2, Khalid Abbas2, Muhammad Rizwan Tariq3, Laiba Shafique4, Ghazala Nazeer5
...or positive control (PC) cyclophosphamide was injected into fish. The tolerance limits of C. catla against END+CPF was computed as 1.35±0.01µgL-1(LC50) and 2.25±0.02µgL-1(LC100). Genotoxic results showed that END+CPF mixture caused significant damage to nuclei (22.58±5.37%) and GDI (0.73±0.15%) in RBCs of fish as compare to control. Aduration-specific damage to DNA was o...
Yan Jiang1,2, Xia Tao3,4 and Hongxia Chen5,6*
...-assisted prednisone and cyclophosphamide on the treatment of idiopathic membranous nephropathy (IMN) and its influence on serum levels of nephrin and B-cell activation factor belonging to the TNF family (BAFF). For this purpose, a prospective randomized controlled study method was designed for this study. 92 patients with IMN in our hospital from December 2015 to December 2017 were divided into study group (n=46) and control group (n=46) based on a computer-g...
Ahmed Alazzouni1, Ashraf Al-Brakati2,*, Sherif Rabie1, Mohamed Gabry1 and Basmaa Hassan1
...en tea and curcumin, and cyclophosphamide (7.5 mg/kg) groups. All groups were treated for one month after the induction of leukemia. We found that the extracts ameliorated most histopathological changes in MLNs and spleens in rats exposed to benzene, restoring normal mast cell counts and elastic fiber area percent in a benzene-induced leukaemia model. To conclude Moringa oleifera, curcumin, and green tea extracts could be used as natural chemotherapeutic agent...
Florence N. Nworah*, Nene O. Uchendu, Ifeoma F. Chukwuma*, Emmanuel C. Ossai and Emmanuel C. Ezeako
...ios sinuatus (turtle) on cyclophosphamide induced myelosuppression in rats. Blood constituents were determined to identify the presence of vitamins and minerals. Thirty albino rats used were grouped into six comprising of five rats each and each group except group A was induced with cyclophosphamide. Group A received normal saline, group B remained untreated, group C, D, E and F were respectively treated with standard haemat...
Indira Jurinskaya1*, Tynyshtyk Kenzhebaeva2, Kairat Iskakov3, Bekzat Niyazbekov1
...uscular injection of the cyclophosphamide drug at a dose of 7 ml/kg of body weight. The results showed one-year-old goats of the Kazakh coarse-haired and Gorno-Altai downy breeds subjected to an intramuscular injection did not show a molt of down, but the output during their brushing was, respectively, 14.3 and 7.8% higher than that of the peers in control groups due to better separation of down. The down output in experimental animals partially increased and ...
Muhammad Nasir Bhaya1,2* and Hikmet Keles2
Xiaowei Huang, Yajie Wang, Jia Zhou, Junxiu Liu, Zhe Lin and Ruili Li*
...ablished by injection of cyclophosphamide (CTX) intraperitoneally. 60 SD rats were randomly divided into 6 groups, control, model, positive drug (compound E-jiao slurry), SBG high-, medium- and low-dose (SBG-H, SBG-M, SBG-L) groups. After 21 days of intervention, the changes of thymus and spleen indexs were compared, the levels of white blood cell (WBC), red blood cell (RBC), hemoglobin (Hb), hematocrit (HCT) and platelet count (PLT) in peripheral blood were d...
Mustafa M. Khalaf*, Rana A. Salih
...sorders are treated with cyclophosphamide (CPA). However, as a result of its serious negative consequences, including liver damage associated with oxidative stress, its therapeutic usage is restricted. The most potent antioxidant among flavonoid chemicals is quercetin, the aim of this study was to evaluate the protective effect of quercetin against cyclophosphamide. An explanation of quercetin’s hepatoprotective effect...
Amer Hakeem Chyad1, Omar S.I. Al-Janabi2*, Orooba Mohammed Saeed Ibrahim1, Najeeb Mohaamed Hussein3
...t and 14.2 mg/kg/B.W. of cyclophosphamide were administered orally via gastric tube. Fourth group (G4): These animals were administered 300 mg/kg/B.W. of Chelidonium majus L. alcoholic extract and 14.2 mg/kg/B.W. of cyclophosphamide orally via gastric tube. Five groups (G5) Animals of this group were administered 400 mg/kg/B.W. of Chelidonium majus L. alcoholic extract and 14.2 mg/kg/B.W. of cyclopho...
