Saba Manzoor1,*, Ali Raza Awan1, Abdul Wajid1, Sehrish Firyal1, Muhammad Tayyab1, Muhammad Mansha2, Asim Khalid Mahmood3, Abu Saeed Hashmi1 and Muhammad Wasim1,*
...votal role in diagnosis, prognosis and comparative studies. c-Myc gene was selected to study the mutation and expression profiling of different canine and feline tumors due to its predetermined role in tumor pathogenesis. A total of 52 tumor and normal samples were examined, among these, 40 canine and 12 feline samples were analyzed using Sanger sequencing method and RT-qPCR for the mutation and expression profiling of c-Myc gene. The coding regi...
Tania Ahmed Shakoori1,*, Muhammad Saqib Saeed2, Asif Hanif2, Saima Mukhtar3 and Ayesha Ghauri4
... directly related to the prognosis of the disease. The objective of this study was to identify the ‘frequent exacerbator’ phenotype and determine the risk factors for increased frequency of acute exacerbations in local chronic obstructive pulmonary disease (COPD) patients in a cross sectional analytical study design. For this purpose 137 patients were included in the study after obtaining necessary permissions from the ethical board of the hospital...
Munir Ahmad1, Aisha Hameed2*, Saba Khaliq3, Hamid Saeed Malik4 and Shahida Mohsin5
...rtant parameters of good prognosis. The objective of this study was to detect the frequency of TEL-AML1 fusion oncogene in ALL and its association with already established prognostic factors such as age, WBC count and FAB subtype.
Materials and Methods: Sixty-six patients with newly diagnosed ALL were studied and patients on chemotherapy and T-ALL were excluded. The data was analyzed by SPSS20 for prognostically important parameters such as ...
Ankur Abrol, Madhumeet Singh, Akshay Sharma* and Pravesh Kumar
...al examination. However, prognosis of uterine torsion is mainly dependent on the degree and duration of condition and can be categorised into 3 successive stages i.e. stage of positive prognosis, stage of less positive prognosis and stage of negative prognosis. Body condition assessment of the dam is of paramount importance as it can provide a snapshot a...
Bibi Nazia Murtaza1, Mazhar Saeed Chaudry2, Shamaila Inayat Nadeem1, Muhammad Shahid Nadeem3 and Abdul Rauf Shakoori4,*
...cending colon with worst prognosis of disease. Through mutagenic PCR, codon 12 was analysed by creating a single nucleotide mismatch at the 3′-end of primers to produce a BstNI recognition sequence at codon 12 while codon 13 was analysed by introducing HaeIII recognition sequence. By using RFLP and sequencing, point mutation substituting the glycine (GGC) to aspartic acid (GAC) was observed at codon 13. The p.G13D or cDNA.230G>A/ g....
Bo Gao1,2, Fengmei Yang3, Wei Chen2, Xiaojia Song4, Xiaobo Liu5 and Dongmin Li1*
Mai A. Kilany1; Hanaa H.A. Gomaa1; Yousry E. Abo El-magd2 and Nermin Raafat2.
Eman H. Mahrous1, Mohamed. W. Abd Al -Azeem2, Faisal A. Wasel1, Waleed Younis2*
...economic losses and poor prognosis in Egypt. So, this study aims to detect and identify P. multocida isolated from rabbits by molecular techniques. To establish this goal, lungs, liver, and heart (50 for each organ) were collected from 50 diseased rabbits (suffering from respiratory signs) from backyard rabbits at different localities in Sohag governorate, Egypt. All samples were submitted for PCR test and other conventional methods of identification. Recover...
Zhaojun Wang1, Yang Zhou2 and Xinghua Song3*
...nalyze its effect on the prognosis of knee joint function. A total of 120 knee osteoarthritis patients admitted to our hospital from January 2019 to February 2020 were selected as the study subjects and randomly divided into control group and observation group (60 cases each). The control group was given injection of sodium hyaluronate in knuckle articular cavity, and the observation group was further treated with compound betamethasone. Clinical efficacy of t...
Md. Sabuj Rahman and Md. Mahmudul Alam*
...flammatory drugs, a good prognosis in the calf was noticed. After 1 month, a mild skin problem occurred which was minimized simultaneously....
Man Wang1 and Fengmei Yang2*
...ression and methylation, prognosis and immune cell infiltration in databases. The expressions of TOP2A gene and protein in tumor tissues were higher than those in normal tissues, and the differences were statistically significant (P<0.05); TOP2A gene expression was positively correlated with immune cells infiltration (P<0.05); the overall survival, disease-free survival and survival probability of patients with high expression of TOP2A gene were lower th...
Chun Shi, Juanjuan Guo, Meng Li, Qi Yang and Jingang Li*
...sive disease with a poor prognosis and high fatality rate. However, whether it can promote or slow down intestinal ischemia-reperfusion injury remains unclear. Spermophilus dauricus is a hibernation animal with a short awake time that interrupts the long hibernation period. When these events occurred, the long-term ischemic intestine in hibernation rapidly congested and entered the hibernation and ischemic state again. However, Spermophilus dauricus is not sic...
Bing Yan1, Meng Meng Zhang2, Xi Chen2, Yongming Li2*, Muhammad Khan3* and Tonghui Ma1*
...therapeutic methods, the prognosis of GBM still remains very poor. The poor prognosis is associated with cancer stem cells (CSCs) which hold the potential of self-renewal, and differentiation into pathogenomic heterogeneous tumor formation leading to therapeutic resistance. Therefore, targeting CSCs and their associated signaling pathways is crucial for effective treatment of GBM. In this study, we showed that alantolactone ...
Qiangsheng Wu1, Yumei Yin2, Hui Gao1, Baoding Chen3, Jianjun Yu2, Jian Zhang4, Donglai Zhu5, Fang Liu6, Guohong Ge7 and Ya-Mei Dang8*
...ly correlated with worse prognosis of survival, which may be potential diagnostic and therapeutic targets of HCC....
Qi Jiayi1, Huang XuMiao2, Lin Wei3, Ao YaHui3, Zhao Wenting2* and Cao Chunhao3*
...n provide assistance for prognosis prediction and immunotherapy of SKCM....
Qingsen Ran1,2, Manjing Li3, Jiayin Han3, Lifang Wang3, Han Wang3,4, Shaobo Liu5* and Yanping Wang1*
... genes in predicting the prognosis of colon cancer (CC), a common invasive gastrointestinal tumor. In this study, clinical and gene data were collected to identify glycolytic genes that significantly associated with overall survival (OS) rate of CC patients through gene set enrichment analysis (GSEA) and Cox regression models. The K-M method was used to determine the difference of OS rate with high and low risk scores. The accuracy of risk scores were determin...
Muhammad Wasif Gulzar*, Riffat Maqsood, Muhammad Zain, Muhammad Suleman, Tayyab Ur Rehman, Sana Asif, Abdul Wadood and Jawad Hussain
...ic symptoms and a deadly prognosis. The Rabies virus uses several strategies to circumvent the host’s defenses. As a major zoonosis, initial treatment and successful preventive and control efforts depend on a clear and prompt diagnosis. For the diagnosis of Rabies, conventional techniques such as Direct Fluorescent Antibody Test (dFAT) and histopathology are still employed. The OIE and WHO both frequently propose the gold standard test, the Direct Fluore...
Muhammad Usman1*, Aneela Zameer Durrani1, Nasir Mehmood2, Muhammad Hassan Saleem1 and Mamoona Chaudhry3
...vely used to monitor the prognosis of Lyme borreliosis in pet dogs. These results will be helpful for the pet clinicians and veterinarians working to diagnose, treat, and monitor Lyme borreliosis under field conditions....
Yan Wang1,2*, Lin Liu3, Na Li4, Yijun Zong1, Wei Liu1, Wenhua Xu1, Qi Wang1, Peijuan Zhang1 and Huiling Feng2,5*
... expression and survival prognosis. Western blot was used to detect the protein expression of proteins. RT-PCR was used to detect the mRNA expression level of genes. Cell proliferation was discovered using the CCK8 test and plate cloning. The impact on the cell cycle was examined by using flow cytometry. The production of glycolytic enzymes and the significance of LY6K in the development of lung cancer in naked mice were both noted. The effects of LY6K knockdo...
Ali Asghar Khan
...us wallichiana). The prognosis of this approach is discussed briefly, to create awareness about the effects of unwarranted
changes in environment and need for studying the factors involve don pilot basis.
...
Lei Chu1, Jie Yang2, Zhenshi Chen2, Xiajun Zhang1, Weidong Wu3*, Shaoru Zhang2 and Lihui Wang2*
... tumor in women, and its prognosis is poor. The key genes and pathways of CC need to be further discovered. GEO2R was used to identify differentially expressed genes (DEG), GO and KEGG enrichment were analyzed by DAVID. Then, the PPI network is constructed with strings. The HUB gene and module of DEGS were obtained by Cytoscape. Finally, GEPIA also analyzed the differential expression and survival of key genes. 234 DEG were extracted from GSE9750. The uterus i...
Heba Ali Salih*, Mohanad A. Al-Bayati
...s, suggesting a negative prognosis. The velocity of sperm within a semen suspension exhibited a marked decrease as the concentration of gold nanoparticles increased. Concurrently, The Fraction of Rapidly Moving Sperm was reduced with increasing Gold nanoparticle concentrations, indicating a negative correlation.The motility index of sperm was notably influenced by the presence of gold nanoparticles, exhibiting a pronounced decline as the concentration of these...
Hongxiao Li1*, Xiying Wu2, Dengxiang Wu1 and Jiangqing Yu1
...atients, and enhance the prognosis of the disease, which can provide a reference for clinical application....
Shrikant Verma1; Mohammad Abbas1,2*; Sushma Verma1; Aliya Abbas Rizvi1; Almas Khan1; Syed Tasleem Raza3; Farzana Mahdi1
Novel Research in Microbiology Journal (2021), 5(4): 1313-1324
...iagnosis, treatments and prognosis. The aim of this review was to summarize how precision medicine is impactful in the management of COVID- 19....
Soumya Nigam1; Urvashi Vijay2*; Bhumandeep Kour3
Novel Research in Microbiology Journal (2022), 6(3): 1601-1613
...enefit in evaluating the prognosis and management strategies....
Yashu Lv*, Yueyue Gao, Jinyi Wang, Yunchun Liu and Guiqing Jiao
...cians to fully judge the prognosis of mother and child and to administer clinical interventions as early as possible, with high diagnostic efficacy....
Hongqi Li1 and Meidong Xu1,2*
...with the of ESCA patient prognosis. TCF3 silencing suppressed ESCC colony-forming capacity and cell proliferation, in contrast, overexpression of TCF3 prominently accelerated ESCC cell proliferation and colony formation. Mechanistically, ACSS2 is a critical nucleocytosolic enzyme that converses acetate to acetyl-CoA, and acts as a TCF3 downstream molecule. TCF3 modulates the aggressiveness of ESCC by regulating the levels of ACSS2. In consistence, ACSS2 knockd...
Hao Weng, Liang Zhu, Zhu Mei, Mingxian Wu and Qiang Xu*
...d on their postoperative prognosis, patients were categorized into a control group (CG) (favorable FNF healing, n=100) and an observation group (OG) (non-union FNFs, n=34). Levels of interleukin (IL)-1, IL-6, IL-8, C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-α) were compared at preoperative (D0), postoperative day 1 (D1), postoperative day 7 (D7), postoperative month 1 (M1), postoperative month 3 (M3), and postoperative month 6 (M6). T...
Zhihong Huang1, Xuemei Zhang1, Ling Li1, Min Hu1, Mo Chen1 and Qunchao Mei2*
...rs that confirm the poor prognosis of the disease cannot be introduced alone as a possible candidate for further studies to confirm the role of a poor prognostic biomarker in gastric cancer....
Chunqin Tian1, Lichun Cui1 and Xiaoyan Wang2*
...hese changes and patient prognosis. One hundred thirty-nine GC patients receiving PD-1 inhibitor therapy were enrolled. Peripheral blood (PB) and tumor tissues were collected before treatment (TB), during treatment (TM), and after treatment (TA). Multiple-parameter flow cytometry and immunohistochemical analysis were employed to analyze changes in immune cells and biomarkers. Correlations between these changes with treatment response, overall survival (OS), an...
Mao MeiYa, Sheng Yuehua, Ding Huiqing*, Zheng Xiaojiao and Du Yongming
...h a significantly better prognosis. The functions of differentially expressed MMPs are primarily related to the matrix metalloproteinases signaling pathway, cell surface receptor receptor interactions, and immune response signaling pathway. Our data suggest that JUN, STAT3, ETV4, ETS1, RELA and NFKB1 are key transcription factors for MMPs, and the SRC family of tyrosine kinases (LCK, LYN, and FYN), threonine kinase (ATR and ATM), CSNK2A1,CDK2 and EGFR are MMPs...
Haixiao Zhang1, Xilong Yang2, Yinfeng Li3, Binyu Xu4, Juan Du2,5, Ronghua Wu6 and Sangsang Xiong2*
...ng early and improve the prognosis of the disease....
