Rehana Shahida1, Tasnim Farasat1, Shagufta Naz1,* and Shahjahan2
...atherosclerosis and hyperglycemia within the context of chosen pro atherogenic parameters including plasma glucose level, serum levels of insulin, IL-6, and TNF-α. Serum level of thrombomodulin was assessed as a measure of vascular damage. Different demographic parameters as age, BMI, waist /hip ratio, B.P., personal history and socioeconomic status were recorded. Fasting glucose and HbA1c was done by chemistry analyzer. Fasting serum insulin, IL-6, TNF-...
Faiza Hassan1, Mubshara Saadia1,*, Muhammad Sher1, Mian Anjum Murtaza2, Muhammad Arshad3,Asam Riaz4 and Mahmood Ahmad Khan5
...nd effective against hypoglycemia, hyperlipidemia, and hypercholesterolemia. Present study was designed to evaluate the relative antidiabetic potential of garlic aqueous (AGE) and petroleum ether (EGE) extracts compared to black cumin (Nigella sativa oil; NSO) and insulin. Alloxan induced diabetic rats were post treated with plant extracts (150 mg/kg) and serum samples were collected from overnight fasted diabetic rats on day 15 to observe thepercent ch...
Mian Sajjad Ahmad1, Somia Iqtadar1, Sami Ullah Mumtaz1*, Zafar Niaz1, Iqra Waheed2 and Sajid Abaidullah1
... is associated with hyperglycemia and insulin resistance. To determine the frequency of impaired glucose tolerance in obese patients. This Cross Sectional study was carried out in North Medical Ward, King Edward Medical University/ Mayo Hospital Lahore for 6 months i.e. January to June 2014. Total 160 obese patients visiting outpatient department of North Medical Ward, Mayo Hospital Lahore for 6 months were included by non-probability purposive sampling. Patie...
Chuanpeng Zhou1, Heizhao Lin2,*, Zhong Huang2, Jun Wang1, Yun Wang1 and Wei Yu2
...sulted in prolonged hyperglycemia and high level of hepatic glycogen in T. ovatus which could lead to nutritional stress, and increasing glucose metabolic burden in this species. ...
Abd El-Nasser Ahmed Mohammed1,2,*
... of hypothermia and hyperglycemia due to general anesthesia. Seventy-five albino female mice (21.74 ± 0.19) were distributed into three groups; control (G1; N=25; not receive N. sativa oil) and two N. sativa oil groups supplemented with either 1.0% (G2; N=25) or 2.0% (G3; N=25) for 30 days. Changes of body temperature, heart rate, blood parameters (RBCs, WBCs, hematocrit, hemoglobin, glucose and total protein), oocyte quality after ovarian...
Ahmed Weli Hussein Osman1,2, Rakibul Islam1, Md. Bazlar Rashid1, Abdiaziz Idiris Mohamud2,3* and Pravin Mishra4
Nanoparticle Tactics for the Oral Delivery of Insulin in Alloxan-Induced Hyperglycemia in Rat (Rattus norvegicus domestica) Model
...the alloxan-induced hyperglycemia in rat model. Twenty male rats of age four months were randomly allocated into four different groups (T0, T1, T2, and T3). After acclimatization diabetes was induced in three groups of rats (T1; positive control, T2: insulin only insulin, and T3; insulin with nano particles) by administered alloxan injection at dose of 120mg/kg body weight intraperitoneally. Group T0 was kept for negative control while T1 was kept positive con...
Rana A. Ali1, Abd-Elraheim A. Elshater2, Heba A. Mohammed3*, Mahmoud Elshazly4
...as, that results in hyperglycemia. Streptozotocin (STZ) is a medical agent that could be used in experimental animals to induce diabetes. Nowadays, efforts have been directed and focused on complementary medicine. Aim: Our study was designed to assess the hypoglycemic activity of the laser on diabetic experimental animals. Methods: The present work was carried out on 40 albino rats, and equally divided into 4 groups, (10 rats/group) as following: Group 1, anim...
Asmaa A. Darwish*, Mona A. Mahmoud, Adel M. El-Kattan
...al hyperproteinemia, hypoglycemia, increased kidney function tests, and oxidative stress than the diseased does. Total antioxidant capacity (TAC) and Zn had the highest likelihood ratios among the suggested markers with acceptable sensitivity, specificity, PPV, NPV, and accuracy rates, and their combination yielded better values. The study concluded that the clinicopathological alterations associated with ovine and caprine brucellosis are a mirror for the immu...
Qing Cao1, Wei Jiao2, Huihui Lu1, Jing Zhang2, Meiling Ren3, Yan Xu1* and Shuyang Hu1*
...re divided into the hyperglycemia group (n = 126) and hypoglycemia group (n = 112). Patients in the hypoglycemia and hyperglycemia groups had higher levels of fasting blood glucose (FBG), 2 hPG and glycosylated hemoglobin (HbA1c) when comparing to their counterparts in the control group, with a lower level of fasting insulin (FINS) in serum (all P < 0...
Qing Cao1, Wei Jiao2, Huihui Lu1, Jing Zhang2, Meiling Ren3, Yan Xu1* and Shuyang Hu1*
...re divided into the hyperglycemia group (n = 126) and hypoglycemia group (n = 112). Patients in the hypoglycemia and hyperglycemia groups had higher levels of fasting blood glucose (FBG), 2 hPG and glycosylated hemoglobin (HbA1c) when comparing to their counterparts in the control group, with a lower level of fasting insulin (FINS) in serum (all P < 0...
Eman Ali Hussein1*, Majdy Faisal Majeed2
...ells and results in hyperglycemia in rats, which leads to diabetic nephropathy. The goal of this investigation was to see if Trigonella foenum-graecum (TFG) flavonoid extract could protect the kidneys from the effects of (SZ). The goal of the current study was to determine if the ethanolic extract of (TFG) exhibited antioxidant activity against nephropathy resulting from the effects of diabetes due to (SZ). Animals in groups 2, 3, 4, and 5 were employed as exp...
Idrissi Ouedrhiri Housna1, Bikri Samir1,2*, Benloughmari Douae1, Aboussaleh Youssef1
...us benefits against hyperglycemia and stress-related complications, is particularly intriguing. The primary objective of this study was to investigate whether combining Melatonin and Metformin (MET) could ameliorate biochemical and behavioral changes associated with persistent hyperglycemia, specifically by reducing lipid peroxidation (LPO), a key marker of oxidative stress (OS), in T2DM mice exposed to chronic immobilizatio...
Aamir Khan Awan1, Nighat Sultana1*, Rahmat Ali Khan2, Rifhat Sultana3,
Umm-e-Kalsoom1, Fayaz Ahmed Sahibzada4, Rifat Ullah Khan5, Naimat Ullah Khan6, Nazir Ahmad Khan7, Syed Haider Zaman8, Mir Sadiq Shah9 and Assar Ali Shah10*
...her species against hyperglycemia and biochemical profiles of treated rats. It was concluded that the extracts of peels of P. granatum possess significant antihyperglycemic and antihyperlipidemic potentials due to presence of phytochemical and have no side effects. Based on the outcome of the study it can be recommended that the peel of P. granatum can be further used for the development of antidiabetic drugs or in folk medicines traditionally to treat the dia...
Soumia Ed-Day1*, Meryam Laanaya1, Chaimae El Kourchi3, Radia Elgui1, Fatima Ezzahra Kacimi2, Latifa Didou1, Samira Boulbaroud2, Hicham Harhar3, Fatima-Zahra Azzaoui1
Shireen Ali Hasan1*, Ahlam A. Al-Rikaby2, Maitham Ali Al-Rikaby3
...ads to weight gain, hyperglycemia, hyperlipideamia and liver dysfunction, and highlight the use of animal models to assess important aspect of health. ...
Bassant Mahmoud Emam1, Jehan Abd Elrazek Hassanen1, Abeer Gaffer Ali Hassan3, Azza Mahmoud Abdullah1, Hadeer Said Aboelnaga2, Amina Ali Dessouki2*
...or extract (FSE) on hyperglycemia, dyslipidemia, and hepatic alterations of streptozotocin (STZ)-provoked DM rats. Here, DM was triggered by administrating 10% fructose (Fr) for two weeks, then intraperitoneally injected with a single STZ dosage (40 mg/kg). The study was carried out using 50 male albino rats allocated into 5 groups (n = 10/group): Control, diabetic non-treated, and diabetic groups treated by DAPA (1 mg/Kg b.wt), FSE (250 mg/kg, b.wt) and FSP (...
Ashraf B. Said*, Ibrahim A. Ibrahim, Hoda I. Bahr, Marwa A. El-Beltagy
...ificant (P≤0.05) hyperglycemia, hyperinsulinemia, and elevation in inflammatory cytokines with hepatic and kidney tissues disruption. At the same time, treatment alleviated hyperglycemia and IR with a significant (P≤0.05) decrease in inflammatory biomarkers levels and tissue expressions, especially GLP-1 and Stem cell groups combined with metformin. The study concluded that whether BM stem cells or GLP-1 able to declin...
