Asmaa Hamid1,* and Samia Kalsoom2
...-76-A, three groups were alloxan induced diabetic rats which were fed basic purified diet AIN-76-A, Kabuli chickpea HFD and Bengal gram HFD and were monitored for random blood glucose and weight for a period of six weeks. Another three groups of rats with induced hypercholesterolemia were fed the same diet as the diabetic rats and were monitored for total serum cholesterol. It was found that both Bengal gram and chickpea had a significant effect on lowering gl...
Faiza Hassan1, Mubshara Saadia1,*, Muhammad Sher1, Mian Anjum Murtaza2, Muhammad Arshad3,Asam Riaz4 and Mahmood Ahmad Khan5
Tafail Akbar Mughal1, Shaukat Ali1*, Hafiz Muhammad Tahir1, Shumaila Mumtaz1, Samaira Mumtaz1, Ali Hassan1 and Syed Akif Raza Kazmi2
...phenotype was induced by alloxan. A single injection of Alloxan (150 mg/kg) was applied intravenously to induce diabetic phenotype. Alloxan induction raised the overall level of triglycerides, low density- lipids (LDLs), and cholesterol and reduced the level of high density lipids (HDLs). Oral administration of 200 mg/kg aqueous extract of B. lycium Royleroot bark for 28 days rescue...
Ahmed Weli Hussein Osman1,2, Rakibul Islam1, Md. Bazlar Rashid1, Abdiaziz Idiris Mohamud2,3* and Pravin Mishra4
Nanoparticle Tactics for the Oral Delivery of Insulin in Alloxan-Induced Hyperglycemia in Rat (Rattus norvegicus domestica) Model
...livery of insulin in the alloxan-induced hyperglycemia in rat model. Twenty male rats of age four months were randomly allocated into four different groups (T0, T1, T2, and T3). After acclimatization diabetes was induced in three groups of rats (T1; positive control, T2: insulin only insulin, and T3; insulin with nano particles) by administered alloxan injection at dose of 120mg/kg body weight intraperitoneally. Group T0 was...
Syed Shahid Imran Bukhari1*, Nusrat Jahan2, Muhammad Khalil Ahmed Khan3, Mariam Zaheer1, Sabir Javed1
A.M. Abdul Azeem, Ashraf M. Mounir and Amr N. El-Shahat*
...atalase) in the group of alloxan (150 mg/kg B.WT)-administrated rats as compared to control group. Treatment of diabetic rats with GPSDP (1 g/kg B.Wt/day/ 8 weeks) resulted in significant reduction of glucose level and lipid-peroxidation with amelioration of hormonal disturbance and enhancement of testicular antioxidant status with relative to alloxan-induced diabetic group. Therefore, this study concluded that γ-irrad...
Dhiya Altememy1, Mohammad Darvishi2*, Samira Shokri3, Saber Abbaszadeh4
...aperitoneal injection of alloxan. After the rats were anesthetized, 2cm2 wounds were created and inoculated with bacterial suspension of S. aureus (ATCC 12600) equivalent to the 0.5 MacFarland tube. The hydroalcoholic extracts of Origanum vulgare, Hypericum perforatum, and their active ingredients including carvacrol and hypericin, were prepared, and then TiO2N.Ps. were prepared from them using isopropoxide. The antibiotic methicillin and calcium alginate pad ...
Owolabi Olutunmise Victoria1*, Saka Olusola Stephen2, Olashinde Oluwaseun Ruth1, Alli Smith Yemisi Rufina3
...abetes was induced using alloxan monohydrate.5 ml of normal saline was given to group I , group 2 received 5 mg/kg/ body weight of the standard drug glibenclamide, group 3 was given 140 mg/kg of alloxan while groups Young C. acuminata leaves aqueous extract was administered orally in graded doses to the diabetic animals (50mg/kg, 100mg/kg, 200mg/kg and 400mg/kg bodyweight) and glibenclamide. Results showed a significant redu...
Waheed Khan1, Muhammad Ajmal Khan2, Bakhtawar Khan1*, Aftab Amin3, Muhsin Ali4, Awais Farid, Ali Hazrat5 and Muhammad Yahya5
...aperitoneal injection of alloxan (150 mg kg-1, b.w.) to cause diabetes. There were five groups of mice (n=10): group 1 (normal control) received normal food and water, group 2 (diabetic control) received normal food and clean water, group 3 (diabetic mice) received 200 mg of methanolic plant extract, group 4 (diabetic mice) received 400 mg of methanolic extract, and group 5 (diabetic mice) received 10 mg of the medication Glibenclamide for 28 days. Glucose was...
Rasema Majeed, Alaa Kamil Mahmood*
...cal changes in dogs with alloxan-nicotinamide-induced diabetes. histological analysis was assessed. The results showed that first group (Control negative) administered distilled water showed no abnormal lesion, while second group (Control positive) is diabetic without treatment showed destruction and necrosis of islet cells, congestion and edema between their acini. Third group was administered 81.7 mg/kg BW of ginger ethanolic extract orally for 45 days showe...
SYED SHAHID IMRAN BUKHARI1*, IQRA AZAM1, MUDDASIR HASSAN ABBASI1, MEERAB DAUD1, NADEEM SHEIKH2, ANDLEEB BATOOL3, RABIA MAHMOOD2 & MARYAM MUKHTAR2
HAFIZ MUHAMMAD ARSALAN1,2*, SUMMARA TABASSUM1, MUHAMMAD SHERAZ YASIN3, FAROOQ SALEEM4, ZEEMAL SEEMAB AMIN1, MUNIB ASHFAQ1, UMAR FAROOQ GOHAR5 & RASHIDA BASHIR6
Aamir Khan Awan1, Nighat Sultana1*, Rahmat Ali Khan2, Rifhat Sultana3,
Umm-e-Kalsoom1, Fayaz Ahmed Sahibzada4, Rifat Ullah Khan5, Naimat Ullah Khan6, Nazir Ahmad Khan7, Syed Haider Zaman8, Mir Sadiq Shah9 and Assar Ali Shah10*
...anatum peels extracts in alloxan-induced diabetic albino rats. The diabetes was induced in albino rats using alloxan at the concentration of 150 mg kg-1 body weight. After 15 days, the treated groups with glabinclemide and different varieties of methanolic and aqueous extracts showed a significant (P<0.05) decrease in the blood glucose level as compared to diabetic control while slight differences were seen in body weight...
Amal Mahmood Alwan1*, Thekra Atta Ibrahim1, Ghalib Idrees Atiya Ali2
...reatment sub-groups with alloxan with 5 mg/kg concentration of empagliflozin, once daily for 30 days- and the animals of the first sub-group were left untreated. A through examinations showed pathological and histological changes in the group of animals with induced diabetes without treatment, as well as in the group with diabetes and treated with empagliflozin. These lesions were characterized by the intra-glomerular haemorrhage and infiltration of inflammato...
Mohamed H.M. Abd El-Megid1, A.N. El shahat2, A.M. Abdul Azeem2* and Amal A. Mansour2
... hypoglycaemic effect in alloxan-diabetic rats. The results observed that gamma-irradiation of sesame seeds at different doses induced significant increase in the total phenolic contents and antioxidant activity, significant decrease in the free fatty acids, fungal growth and colony formation and no significant change in the oil contents and fatty acid composition compared to raw seeds. Also, the inhibitory activity on α-amylase and α- glucosidase ...
