Submit or Track your Manuscript LOG-IN

Dose-Dependent Effects of Subchronic Exposure to Glyphosate-Based Herbicide on Behavior and Biochemical Alterations in Adult Rats

Dose-Dependent Effects of Subchronic Exposure to Glyphosate-Based Herbicide on Behavior and Biochemical Alterations in Adult Rats

Abdelghafour El-Hamzaoui*, Mouloud Lamtai, Laila Ibouzine‑Dine, Sofia Azirar, Mohamed Yassine El-Brouzi, Ayoub Rezqaoui, Aboubaker El-Hessni, Abdelhalem Mesfioui

Laboratory of Biology and Health, Department of Biology, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.

 
*Correspondence | Abdelghafour El Hamzaoui, Laboratory of Biology and Health, Department of Biology, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco; Email: elhamzaoui.abdelghafour@uit.ac.ma

Figure 1:
Timeline of the glyphosate-based herbicide (GBH) exposition study. The open field test (OFT), elevated plus maze test (EPM), forced swimming test (FST), nitric oxide (NO), lipid peroxidation (LPO), catalase (CAT).
Figure 2:
Effects of GBH (25, 50, 75 and 100 mg/kg) administration on anxiety associated behaviors in male rats. (A) Total amount time spent in the center (TCA); (B) Number of returns into center area of the arena in the open-field behavior apparatus (NRC); and (C) Number of total squares (NTS) in the open field test. Results are expressed as mean ± SEM. * p<0.05, ** p<0.01, *** p<0.001.
Figure 3:

Effects of GBH (25, 50, 75 and 100 mg/kg) administration on anxiety associated behaviors in male rats. (A) Number of entries in exposed arms (EOA); (B) Total amount of time spent in exposed arms (TOA); and (C) Total number of arms entries (TEA) in elevated plus maze. Results are expressed as mean ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001.

Figure 4:

Effects of GBH (25, 50, 75 and 100 mg/kg) administration on depression-related behavior of male rats subjected to the forced swimming test, immobility time expressed in seconds. Results are expressed as mean ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001.

Figure 5:

Measurement of oxidative stress parameters in the hippocampus after 2 months of GBH exposure (25, 50, 75 and 100 mg/kg). (A) the nitric oxide (NO) levels, (B) Changes in catalase activity, (C) Determination of the lipid peroxidation levels. Results are represented as mean ± SEM. The significance level is 0.05. *p < 0.05, **p < 0.01, ***p < 0.001.

Advances in Animal and Veterinary Sciences

July

Vol. 12, Iss. 7, pp. 1206-1409

Featuring

Click here for more

Subscribe Today

Receive free updates on new articles, opportunities and benefits


Subscribe Unsubscribe