Yi-qiang Ouyang1, Zhen-xin Liang1, Shi-wen Huang2, Ying Zhang3, Shao-shi Luo1, Jin-ning Liang1, Jia-fu Li1, Yu He4 and Song-chao Guo1,*
... acid into the bilateral hippocampus led to significant learning and memory deficits in the Morris water maze test. Pathology analysis of treated animals showed obvious gliosis and neurofibrillary tangles in the cerebral hippocampal area. These results suggest that the tree shrew can recapitulate the major features of AD pathogenesis. To provide the basis for further studies with this new animal model, we used high-throughput sequencing to analyze changes in t...
Kun Wang1,2, Yinglin Cui2, Xu Zhao2 and Changjiang Hu1*
...umber of dead neurons in hippocampus and cortical regions of ICH rats. Furthermore, this treatment significantly increased protein expression of claudin-5, ZO-1 and VE-cadherin while protein expression of DNMT3b and MMP-9 were significantly inhibited. Finally, microRNA-29b level were also lower than the Model group. Our data suggests that XN has significant neuroprotective effects on the ICH model rats, which might help to protect the blood brain barrier by re...
Oussama Zghari*, Mouloud Lamtai, Sofia Azirar, Mohamed Yassine El-Brouzi, Hajar Benmhammed, Aboubaker El-Hessni, Ali Ouichou, Abdelhalem Mesfioui
...y into the right ventral hippocampus. Five days after treatment period, all the rats were subjected to the neurobehavioral tests. The animals were then decapitated and the hippocampus was removed. Biochemical parameters of OS and the histology of Cornu Ammonis 3 (CA3) area of the hippocampus were evaluated. The results clearly showed that Al induced anxiety and depressive-like behaviour an...
Xiaowei Huang1, Chao Ma1, He Lin1, Yuchen Wang1, Yan Xu1, Guangfu Lv2* and Zhe Lin1*
...inding protein (CREB) in hippocampus were detected by western blotting. The results showed that, OR could significantly reduce the contents of CRH, ACTH and CORT in serum and improve the damage of hippocampal structure, and increase the expression levels of GR, MR, BDNF, TrkB and CREB in hippocampus. In conclusion, Oviductus ranae can reduce hypothalamic-pituitary-adrenal (HPA) axis hyperfunction induced by CUMS, increase th...
Abeedha Tu-Allah Khan and Abdul Rauf Shakoori*
...5 TF in male mouse brain hippocampus along with a significant downregulation of three of its predicted interacting partners, i.e., Cop1, Det1 and Bcl6b. Besides presenting new targets for neuroinflammation studies, the discrepancies of expression between different brain regions as well as among the genders suggest that more data with respect to intricate brain region resolution along with single cell data could reflect subtle changes in brain microenvironments...
Xiao-Wei Huang1,2, Mei-Li Liu1, Jin-Ji Wang1, Yue-Xin Liu3, Zhe Lin1, Chun-Shu Rong4* and Ji-Xiang Ren4*
... rapamycin (mTOR) in the hippocampus were detected through western blotting. In the results, VAP contained 17 kinds of AA, including 7 essential AA, with a content of 394.08 g/kg, the total AA content was 831.55 g/kg. In the OFT, the PIR, VAPH and VAPL groups showed significant decreases in slient period, significant increases in exercise time and behavior path, and center residence time in the PIR and VAPH groups were also increased significantly. The MDA con...
Sara Brikat, Mouloud Lamtai*, Miloud Chakit, Laila Ibouzine-Dine, Ilhame Fitah, Oumaima Abouyaala, Abdelhalem Mesfioui, Aboubaker El Hessni
...se activity (CAT) in the hippocampus. The administration of Curc and/or Los increased significantly the recognition index (p < 0.01) as compared with the HFD group, and were able to prevent this effect on the memory induced by the HFD (p < 0.01). Additionally, the levels of TBARS and NO in HFD group significantly exceeded the respective values in female animals when compared to control rats (p < 0.05). In contrast, the administration of HFD + Curc + L...
Laila Ibouzine-Dine1*, Inssaf Berkiks1,2, Mouloud Lamtai1*, Hasnaa Mallouk1, Ayoub Rezqaoui1, Abdeljabbar Nassiri1, Abdelhalem Mesfioui1, Aboubaker El Hessni1
...n the prefrontal cortex, hippocampus, striatum, and hypothalamus of male and female “Wistar” rat pups, as these areas have differential developing states. NO level was determined on postnatal days (PND) 1, 2, 3, 4, 7, 8, 9, 10, 11, 12, 14, 15, 16, and 17. The supernatant nitrite/nitrate (NOx) concentration was assessed after the reduction of nitrates to nitrites using the Griess reaction. Results revealed three distinct periods during postnatal dev...
Abdelghafour El-Hamzaoui*, Mouloud Lamtai, Laila Ibouzine‑Dine, Sofia Azirar, Mohamed Yassine El-Brouzi, Ayoub Rezqaoui, Aboubaker El-Hessni, Abdelhalem Mesfioui
...ing markers of OS in the hippocampus as potential contributors to the observed neurobehavioral changes. Thus, our findings underscore OS as a plausible mechanism explaining the underpinnings of the neurotoxic effects observed following exposure to GBH....
Zhongjiang Niu1, Periyannan Velu2, Annamalai Vijayalakshmi2*
...ing. Neuronal damage and hippocampus swelling were reversed with NF45 in a dose dependent manner. P2y agonist, methylene - ATP, significantly reduced the positive effect of NF45.P2y3 receptors had a significant role in epilepsy kindling. This mechanism has potential in epilepsy therapy and future research....
