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Antigenic Domains of Avian HEV: Bases for Serological Diagnosis of HEV in Avian, Swine and Human

Antigenic Domains of Avian HEV: Bases for Serological Diagnosis of HEV in Avian, Swine and Human

Qin Zhao1,2, Yani Sun1,2, Gaiping Zhang1,3, Frederik Widen4, En-Min Zhou1,2,*

zhouem@nwsuaf.edu.cn

1Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China; 2Experimental Station of Veterinary Pharmacology and Veterinary Biotechnology, China Ministry of Agriculture, Yangling, Shaanxi 712100, China; 3Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Henan Agriculture University, Zhengzhou, Henan 450002, China; 4Department of Virology, Immunobiology and Parasitology, National Veterinary Institute (SVA), 75189 Uppsala, Sweden.

ABSTRACT

Avian HEV capsid protein contains immunodominant epitopes and is responsible for the induction of the protective humoral immune response. Six antigenic domains in the capsid protein have been identified. The fragmented proteins in these domains are analyzed for their application in serological diagnosis of HEV.

 

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Hosts and Viruses

December

Vol. 7, Iss. 6, Pages 129-146

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