Search for Nephrotoxicity

Comparative Effects of Radon Inhalation According to Mouse Strain and Cisplatin Dose in a Cisplatin-induced Renal Damage Model

Kaori Sasaoka¹, Takahiro Kataoka¹, Norie Kanzaki¹, Yusuke Kobashi¹, Akihiro Sakoda², Yuu Ishimori² and Kiyonori Yamaoka^1,*

...ers; however, it induces nephrotoxicity caused by oxidative stress. Here, we investigated whether radon inhalation has different effects against CDDP-induced renal injury in two mouse strains differing in radiosensitivity, and determined the appropriate dose of CDDP combined with radon inhalation for highly radiosensitive mice. CDDP was administered at 20 mg/kg weight to C57BL/6J and BALB/c mice after radon inhalation at 1000 Bq/m³and 2000 Bq/m

Haematological and Histopathological Analyses of Levofloxacin Induced Toxicity in Mammals

Chaman Ara¹*, Asmatullah¹, Sehrish Kanwa¹, Asma Chaudhary², Ayesha Siddiqua¹

... induced hepatotoxicity, nephrotoxicity and its likely noxious effects on spermatogenesis in mammals. Forty mice, randomly categorized into four groups (N=10) were administered orally with different concentrations of levofloxacin (0.00, 9.37, 18.75 and 37.50µg/g BW of mice) for 30 days consecutively. Mice were sacrificed on 31^st day (24 hours after last dose administered) under deep chloroform anaesthesia. Blood was extracted through cardiac p...

Protective Effect of Tamarind against Renal Injury Induced by Gamma Rays

Sameh S. Tawfik, Ahmed A. Elkady* and Ehab T. Mohamed

...nst γ-rays-induced nephrotoxicity in irradiated rats was investigated. Forty albino-rats were divided into four groups: Control, rats were orally administered the vehicle for 6weeks, TSE-treated (each rat received 230mg TSE; once daily, for 6weeks), irradiated (animals subjected to whole body γ-rays (8Gy), and TSE-treated and irradiated (each rat received 230mg TSE; once daily for 6week, then one-hour later after last-treatment, rats were exposed t...

Insight into the Mechanism of Doxorubicin-induced Nephrotoxicity through Gene Expression Analysis of Oxidative Stress, Kidney Injury and Inflammation Markers

Uzma Jabeen¹, Asmat Salim²*, Irfan Khan², Nadia Naeem³ and Rubina Mushtaq⁴

Biochemical and Histopathological Effects of Repeated Low Oral Doses of Malathion, Metalaxyl and Cymoxanil on Different Tissues of Rats

Ahmed H. Massoud¹, Mohamed S. Ahmed², Moustafa Saad-Allah¹, Aly S. Derbalah¹, Ashraf Albrakati³* and Ehab Kotb Elmahallawy⁴*

...ally, hepatotoxicity and nephrotoxicity were obvious in rats treated with cymoxanil, meanwhile, neuronal and pulmonary changes were nearly the same in all doses of the used pesticides. Taken together, our study recommends examining pesticides for their possible adverse effects on animals and humans in case of repeated use, even in small doses, before their application to agricultural fields.

...

Chia Seeds Oil Inhibits Hepatic Resistance to Doxorubicin Via Suppressing Cyp3-A4 and Mrp-1 in Male Albino Rats

Shaimaa A.Tawfik2,3, EL S.T. Awad1*, Hoda O.Abu Bakr1, Amira M.Gamal-Eldeen4, Esmat Ashour2, Ismail M.Ahmed1

...ssion in hepatotoxicity, nephrotoxicity and cardiotoxicity induced by DOX in male albino rats evidenced by a significant enhancement in the activity of ALT, GGT, LDH, AST, also creatinine and uric acid. CSO induced antioxidant activity GSH, CAT and inhibited MDA. Histopathological examination in sections of liver, kidney and heart tissues were confirmed these findings. In liver tissues, DOX resulted in an observable induction in CYP3A4 and MRP-1, while CSO/DOX...

Therapeutic Effects of Rocket Leaves (Eruca sativa) against Hepato-Renal Toxicity Caused by Xylene in Wistar Rats

Rahma Boukarine*, Leila Hamdi and Kamel Khelili

...duced hepatotoxicity and nephrotoxicity in wistar rats, while the combination of this solvent with rocket aqueous extract (Eruca sativa) attenuated this toxicity thanks to its antioxidant property.

...

Erlotinib and Garcinia Cambogia Prevent Adenine Induced Nephrotoxicity in Adult Male Albino Rats Through Modulating EKR1/2, STAT3, and p53 Apoptotic Pathways

Dalia M. Amin1*, Noha Mohammed Halloull1, Walaa E. Omar2, Basma A. Ibrahim2, Nahla M. Ibrahim1

Deleterious Effects of Mercuric Chloride Toxicity Initiated Partially from Physiological Disorder of Kidney, Immunocytes and Redox System, can be Reversed by Resveratrol Administration

Rusul Adnan Dawood, Hasan F.K. Alghetaa*

The Protective Effect of Ellagic Acid on Cyclophosphamide Induced Renal Damage in Rats

Muhammad Nasir Bhaya^1,2* and Hikmet Keles²

Histophysiological Effect of Rosuvastatin on the Kidney in Male Albino Rats

Haneen Imad Al-Sultani1*, Ahmed Obaid Hussain1, Hazar Shakir Saleh2

...tin in high doses causes nephrotoxicity.

...

Aqueous Myrrh Extract Relieves Oxidative Stress-Dependent Nephrotoxicity Induced by Ethanol in Male Rats

Abeer Alahmari^1,2*

...idative stress-dependent nephrotoxicity caused by ethanol in rats. Male Sprague‒Dawley rats orally received 40% ethanol (3 g kg-1) and were then orally treated with (500 mg kg-1) AME daily for 30 days. Kidney function, oxidant and antioxidant status, and histopathology alterations in renal tissue were measured. Animals that received ethanol displayed nephrotoxicity, as confirmed by markedly increased serum creatinine, ur...