Search for Nephropathy

The Effect of Rituximab assisted Prednisone and Cyclophosphamide on the Treatment of Idiopathic Membranous Nephropathy and Its Influence on Serum Nephrin and BAFF Levels

Yan Jiang^1,2, Xia Tao^3,4 and Hongxia Chen^5,6*

...of idiopathic membranous nephropathy (IMN) and its influence on serum levels of nephrin and B-cell activation factor belonging to the TNF family (BAFF). For this purpose, a prospective randomized controlled study method was designed for this study. 92 patients with IMN in our hospital from December 2015 to December 2017 were divided into study group (n=46) and control group (n=46) based on a computer-generated random number table. On the basis of conventional ...

Descurainia sophia Reduces Podocyte Damage in Diabetic Nephropathy by Down Regulating LncRNA KCNQ1OT1

Sheng Dong¹*, Ning Li², Jiawei Zhang² and Ting Wang²

...ocyte damage in diabetic nephropathy.

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Effects of Tetrahydroxystilbene Glucoside on VEGF and MMP-9 Protein Expression in Kidney Tissues of Rats with Diabetic Nephropathy

Xiaojing Liu and Zhongxin Li*

...coside (TSG) in diabetic nephropathy (DN) rats and analyze its action on vascular endothelial growth factor (VEGF) and matrix metalloproteinase (MMP-) 9 protein expression in kidney tissues, in order to reveal the mechanism of TSG. After 12 weeks of administration, compared with those in the DN modeling group, 24 h urine protein, serum creatinine (Scr), blood urea nitrogen (BUN), blood uric acid (UA), alanine aminotransferase (ALT) and aspartate aminotransfera...

Genetic Polymorphism of ACE (I/D) is Associated with Diabetic Nephropathy in Pakistani Subjects

Umara Amir ud Din¹, Waqas Ahmed Khan¹*, Khurrum Shahzad^1,2, Basharat Ali³, Misbah Hussain^1,4 and Fazli Rabbi Awan⁴

...lign: justify;">Diabetic nephropathy (DN), also known as diabetic kidney disease (DKD), is a leading cause of morbidity and mortality in diabetic patients. A major cause of DKD is high blood pressure (hypertension) which remains uncontrolled chronically. Renin angiotensin aldosterone system (RAAS) is a major regulator of the blood pressure, electrolytes and fluid homeostasis. RAAS plays a key role in modulating the sodium metabolism, vasoconstriction, vascular...

Trigonella foenum-graecum Extract’s Effectiveness of Improvements in Renal Functions and Histological Profiles in Male Rats with Streptozotocin-Induced Diabetes

Eman Ali Hussein¹*, Majdy Faisal Majeed²

... which leads to diabetic nephropathy. The goal of this investigation was to see if Trigonella foenum-graecum (TFG) flavonoid extract could protect the kidneys from the effects of (SZ). The goal of the current study was to determine if the ethanolic extract of (TFG) exhibited antioxidant activity against nephropathy resulting from the effects of diabetes due to (SZ). Animals in groups 2, 3, 4, and 5 were employed as experimen...

Renoprotective Impact of Dapagliflozin and Mulberry Extracts Toward Fr-STZ Induced Diabetic Nephropathy in Rats: Biochemical and Molecular Aspects

Emad M. Gad¹, Haidy G. Abdel-Rahman², Mohy Eldin Abd-El-Fattah¹, Merna M. Kamal¹, Ahmed Shaker Eltahan³, Amina A. Dessouki³*

...sease (ESRD) is diabetic nephropathy (DN), which is also rated as a major microvascular complication of diabetes mellitus. The prevalence of diabetic nephropathy is more than 40% of diabetic patients. Even with current treatments, many individuals with DN progress to end-stage renal disease and needing dialysis or kidney transplantation. So,the development of new prevention and treatment strategies of diabetic

TGF-β Mediates the Role of P53 and microRNA-Related Signaling Pathways in the Pathogenesis of Diabetic Nephropathy in Rats

Yonghong Ma¹, Jinlan Ma², Qifu Zhang³, Huajie Zou¹ and Shenghua Ma¹*

... development of diabetic nephropathy. The sample of rats was randomly assigned to a control group and an experimental group, and a rat model of diabetic nephropathy was established. After the establishment, HE staining, immunohistochemical staining and real-time quantitative PCR were performed to compare the groups. The situation after the successful model creation; observe the two groups of TGF-β1, P53, microRNA103 and...