Muhammad Aamir Khan*, Abdul Saboor*, Rauf-i-Azam**, Abdul Qayyum Mohsin* and Fayyaz-ul-Hassan***
IMPACT OF AGRICULTURAL TRADE LIBERALIZATION ON INCOME INEQUALITY IN PAKISTAN
...ucing poverty. In this backdrop, the current study evaluates the impact of Pakistan’s agricultural trade liberalization using a modified Global Trade Analysis Project (GTAP) framework. The newly developed MyGTAP program was used to modify the Pakistan’s data in the Global GTAP Database and Standard GTAP model to include multiple households and labor types. This disaggregation allows to analyze distributional impacts and to implement policy scenario...
Ping Jiang1 , Zhihui Zhao1, 2, Xiaohui Li2, Mengyan Wang2, Lixin Xia2, Yang Cao3, Runjun Yang2 and Xibi Fang2*
...ology to specifically knockdown expression levels of the endogenous gene ABCA1 in bovine mammary epithelial cells (BMECs) to analyse the effect on intracellular triglyceride (TG) content by quantitative real-time polymerase chain reaction (qRT-PCR), Western blot, cell TG Assay and RT2 Profiler PCR array. The results showed that ABCA1 knockdown reduced the TG content in BMECs. On the other hand, the RT2...
Mahak Fatima1, Memoona Syed1, Rabia Zeeshan2, Farah Rauf Shakoori3, Naveed Shahzad4, Moazzam Ali1 and Zeeshan Mutahir1*
...ion, MTH1 protein was knockdown to approximately 77% in the transfected sample and resulted in a 1.75-fold increase in sensitivity of MCF7-R cells to gemcitabine. Moreover, higher expression of p21 protein was also observed in transfected MCF7-R cells that may indicate induced cell death. This study highlights the effect of MTH1 gene silencing in drug-resistant cancer cells as a mean to improve combined therapies for targeting drug-resistant cancers.
Maryam Yousaf1, Naveed Shahzad2, Zeeshan Mutahir1 and Moazzam Ali1*
...tance, siRNA mediated knockdown of Rab21 was performed. Results showed that the knocking down of Rab21 decreased the drug efflux ability of PC-3/Res cells, possibly by altering the surface localisation of MRP-1. These results suggest that interruption in MRP-1 trafficking to the plasma membrane by Rab21 is a potential strategy to overcome multi drug resistance in cancer cells.
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Muhammad Zubair1, Habib Ahmad2*, Brian E. Hemphill3, Muhammad Tariq4 and Muzafar Shah5
...were considered in the backdrop of living ethnic groups of peninsular Indians and prehistoric inhabitants of the Indus Valley and South-Central Asia. When consideration was limited to the people of Northern Pakistan, the uniqueness of Khalil and Daudzai, was emphasized. A comparison of the people from Peshawar emphasizes the uniqueness with south-central Asia, and shared no affinities to South Asians either living or prehistoric. These results show the influen...
Arshad Bhat1*, Masudul H. Wani1, Shabir A. Wani2, Abid Qadir3, Iqra Qureshi4 and Abid Sultan2
...and invisible. In this backdrop, present study attempts to highlight involvement of invisible costs in apple industry of Union Territory of Jammu and Kashmir. Defensive Expenditure Method and Willingness to Pay Model was used to estimate the costs incurred on the health and protective items purchased for reducing the impact of excessive pesticide use on health and ecosystem. Furthermore, Contingent Valuation Method was employed for knowing the willingness of t...
Mian Ibad Ali Shah*, Yasir Saleem Afridi and Laiq Hasan
...government implemented lockdown index, etc.) on the new/ active COVID-19 cases, so policies can be devised accordingly to control the spread of the disease. The data was first converted into summary numbers, followed by carrying out the statistical analysis that yielded meaningful results. Descriptive analysis in particular performs best to achieve this strategy. Descriptive analysis comprising of various methods and factors have been used to infer conclusions...
Anwar Khan1, Fareeha Nosheen2,4, Bushra Tabassum2*, Olawale Samuel Adeyinka2, Khurram Shehzad3, Naila Shahid2, Arif Muhammad Khan4 and Idrees Ahmad Nasir2
...A 1 and siRNA 2 where knockdown percentages were only 20 and 73.04%, respectively as revealed by realtime PCR. Maximum knockdown values were obtained at 100 nM concentration of siRNA 1 and 2, while for siRNA 3 promising knockdown was obtained at 50 nM concentration. For long lasting effect of siRNAs, short hairpin RNA corresponding to siRNA3 was designed and tested against CP-PVX which res...
Mirza Gul1*, Muhammad Zahid1, Ikram Ilahi2, Hazrat Ali2*, Fida Hussain3 and Muhammad Anwar Sajad3
...respectively. Percent knockdown after 1 h exposure was 49.0 for A. scoparia. KDT50 and KDT90 values for A. scoparia were 69.7 and 763.5 min, respectively. LC50 values for A. scoparia and A. indica against adult mosquitoes were 0.266 and 3.364 per cent respectively. A linear relationship was found between extract concentration and mosquitocidal activity. Regarding predatory control, it was found that during a 12-hour laboratory study, A. cybister consumed 10 ex...
Syarif Husen1*, Devi Dwi Siskawardani2, Setiawan Deny Rexmardi1, Erny Ishartati1, Muhidin Muhidin1, Jumpen Onthong3 and Ivar Zekker4
Kanwal Hanif1, Dilbar Hussain1, Qurban Ali1, Asad Aslam1*, Tamsila Nazir1, Muhammad Saleem1, Muhammad Faheem Akhtar1, Muhammad Zubair2, Najuf Awais Anjum3 and Muhammad Umar Qasim1
...d Nitenpyram had less knockdown effect as compared to other insecticides while Lufenuron was most toxic at 4 h post treatment and at 24 h all the insecticides were equally toxic to the parasitoid at adult stage....
Ishtiaq Ahmad1,2* and Muhammad Akbar Anjum1
S. M. Ashraful Karim1, Md. Shohel Al Faruk2*
Abdul Kabir1, Muhammad Rasheed2, Hubdar Ali Kaleri5, Depeesh Kumar Bhuptani3, Mithan Kumar4, Raza Ali Mangi6, Abdul Wahid Solangi4, Sheva Dari1, Saqib Kakar4, Panah Munir4, Ekra Akbar4 and Rameez Raja Kaleri4,5*
...ona virus. In Covid 19 lockdown situations different types of industries got suffered and including livestock and poultry farming at high range. In the December of 2019, outbreak of corona virus started in China. The most common symptoms of this viral infection was observed and reported by the International Committee on the Taxonomy of Viruses SARS Cov 2. Main signs and symptoms of infections has been observed, tiredness, shortness in respiration, pain in ches...
Ahmed Abdul Gafar
... the COVID-19 pandemic lockdown affected the activities of the rice farmers, the rice supply chain to find out if the general view of the impact from literatures is similar or different and then propose pro-active measures/strategies to mitigating shocks against any future outbreak. Data were collected from over 300 households which include about 165 rice farmers. All the rice farmers are male, with an average age of 34 years with majority 87% reside in rural ...
Farah Naz1*, Asad Umair2 and Ghazala Noureen3
...osing long, nationwide lockdowns in an attempt to “flatten the curve”-a term that refers slowing down the spread of the disease in order to prevent healthcare facilities from being overwhelmed by too many new patients. However, lockdowns and related strategies designed to minimize the spread of the pandemic, like early detection, isolation of confirmed cases, and social distancing, were build and implemented on t...
Lei Jiang, Yi Huang, Runfeng Yang, Xiaohui Jiang* and Hao Yan
...geted miR-455-5p, and knockdown of circ_0009910 up-regulated the expression of miR-455-5p in SKOV3/DDP cells. Overexpression of miR-455-5p can enhanced cisplatin sensitivity of SKOV3/DDP cells. miR-455-5p targeted PAX2 and overexpressed miR-455-5p down-regulated the expression of PAX2 gene in SKOV3/DDP cells. Inhibition of miR-455-5p or overexpression of PAX2 reversed the enhanced cisplatin sensitivity of knockdown circ_0009...
Yajuan Zheng, Qiuping Mo, Hongchao Tang, Qinghui Zheng and Dandan Guan*
...ction. Construct LGR5-knockdown, LGR5-overexpressing and LGR5-ΔC-overexpressing (lack of C-terminal tail) human colon cancer LoVo cell lines. The mechanism of the reaction between LGR5 and IQGAP1 was examined by immunoprecipitation. Expression of LGR5 and phosphorylation ratio of IQGAP1 showed opposite trends in breast cancer and normal body. Viability, migration and invasion ability of breast cancer cells were all affected by LGR5 expression and IQGAP1 ...
Irfan Safdar Durrani*, Noreen Asim and Ammar Sohail
Faiza Naeem1, Muhammad Farooq Sabar1, Muhammad Usman Ghani2,*, Qurat Ul Ain1 and Qurat-ul-Ain Zafar1
...sis representing that knockdown of influential node and edge leads toward the development of the disease. This ranking allows identification of the influential protein for the targeted drug discovery and therapies. An extensive study of published articles was conducted to enlist asthma-associated genes reported significant (P-value < 0.05) in the Pakistani population. Pathway Connector (http://bioinformatics.cing.ac.cy/PathwayConnector) was used to analyze ...
Karima Akool Al-Salihi1*, Luay Jumaah Jihad2, Abbas Najm Aldin Saleh3
...ify;">During COVID-19, lockdown was applied worldwide to reduce pandemic circulating. This study intended to investigate the influence of the COVID-19 lockdown on the distribution of animal and zoonotic diseases and its effects on Veterinary Medical Education (VME) in Iraq. A cross-sectional analysis was designed and the participants were invited to answer an online questionnaire on veterinary medical online education. Data ...
