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The Restorative Effect of Titanium Dioxide Nanoparticles Synthesized with Origanum vulgare L., Carvacrol, Hypericum perforatum L., and Hypericin Loaded in Calcium Alginate Scaffold on Staphylococcus aureus-Infected Ulcers in Diabetic Rats

The Restorative Effect of Titanium Dioxide Nanoparticles Synthesized with Origanum vulgare L., Carvacrol, Hypericum perforatum L., and Hypericin Loaded in Calcium Alginate Scaffold on Staphylococcus aureus-Infected Ulcers in Diabetic Rats

Dhiya Altememy1, Mohammad Darvishi2*, Samira Shokri3, Saber Abbaszadeh4 

1Department of Pharmaceutics, College of Pharmacy, Al-Zahraa University for Women, Karbala, Iraq; 2Faculty of Aerospace and Subaquatic Medicine, AJA University of Medical Sciences, Tehran, Iran; 3Department of Environmental Health, Food Safety Division, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran; 4Department of Biochemistry and Genetics, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.

*Correspondence | Mohammad Darvishi, Faculty of Aerospace and Subaquatic Medicine, AJA University of Medical Sciences, Tehran, Iran; Email: [email protected], [email protected] 

Figure 1

Wound healing steps in different treatment groups (day 3-21) - Grage 1-8 (H&E staining) 

Figure 2

A: Tio2 N.P. synthesis by Hypericin ؛ B: Calcium alginate pad (Nondiabetic rat)؛ C: Tio2 N.P. synthesis by Origanum vulgare; D: Tio2 N.P. synthesis by Hypericum perforatum; E: Methicillin; F: Calcium alginate pad (Diabetic rat); G: Tio2 N.P. synthesis by Carvacrol; H: Tio2 N.P. (Highest to lowest collagen density in different NPs treated rat A-H) 

Figure 3

H&E staining Photomicrograph of angiogenesis (groups A-C) - A: Hypericin Tio2 N.P. ؛ B: Calcium alginate pad (Non-diabetic rat) ؛ C: Tio2 N.P 

Advances in Animal and Veterinary Sciences

December

Vol. 12, Iss. 12, pp. 2301-2563

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