The Effect of Polycystic Ovary Syndrome on Physiological and Biochemical Indicators in Albino rabbits
The Effect of Polycystic Ovary Syndrome on Physiological and Biochemical Indicators in Albino rabbits
Wasan Abdulmunem Taha1*, Umer Abdullah Ahmed Alelyan1, Raid D. Hashim2, Zainab Nizar Jawad3, Mohammed Khaleel Jameel4, Mohammed Ahmed Mustafa1
ABSTRACT
Polycystic ovary syndrome (PCOS) is a multifaceted endocrine ailment which affects large number of women during their reproductive years and results in heterogeneous metabolic and hormonal derangements. The current study aimed to evaluate the effect of PCOS on blood glucose levels and liver enzyme. A total of 100 grown up, reproductive adult female Albino rabbits was divided into two groups (n = 50). In the control group PCOS wasn’t motivated, while in the residual other group (n = 50) PCOS was motivated with a alone i.m. testosterone injection every day. Biomarkers assessed include: Glutamic-Oxaloacetic Transaminase (GOT), Alanine Aminotransferase (ALT), Alkaline Phospahatases (ALP), Blood glucose, Luteinizing hormone (LH) and Insulin hormone. The research identifies a gap in the current understanding of the specific biochemical effects of PCOS on liver enzyme activity, glucose metabolism and LH disorder. The study aims to fill this gap in providing an exhaustive explanation of relation between PCOS and these biochemical markers. However, further results indicate female PCOS rabbits to exhibit pronounced alterations in liver enzyme levels together with blood glucose concentration, LH and insulin indicative of a metabolic and hormonal link for this syndrome. These findings indicate the significance of obligatory metabolic control in female rabbits with PCOS and suggest an attuned clinical intervention program to either clear out management strategy properly, further experiments are urgently warranted. Within this study, we have identified distinct patterns of ovarian gene expression underlying PCOS which could open new avenues for refined clinical diagnostics and treatment strategies in the future.
Keywords | Polycystic ovary syndrome (PCOS), Liver enzymes, Blood glucose, Luteinizing hormone, Insulin hormone
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November 2024
Vol. 12, Sp. Iss. 1
