Shenhong Buxue Granules Improve the Vascular Endothelial Injury and Hematopoietic Function in Rats with Aplastic Anemia
Shenhong Buxue Granules Improve the Vascular Endothelial Injury and Hematopoietic Function in Rats with Aplastic Anemia
Xiaowei Huang, Yajie Wang, Jia Zhou, Junxiu Liu, Zhe Lin and Ruili Li*
Fig. 1.
Effect of SBG on thymus index (A) and spleen index (B) of rats.
Notes: C, control group; M, model group; P, positive drug group; SBG-H, SBG high-dose group; SBG-M, SBG medium-dose group; SBG-L, SBG low-dose group; n = 10, ̅x±s. Compared with control, ## P <0.01; Compared with model, * P <0.05, ** P <0.01.
Fig. 2.
Effect of SBG on haematological parameters of rats: A, RBC; B, Hb; C, HCT; D, WBC; E, PLT
RBC, red blood cell; Hb, hemoglobin; HCT, hematocrit; WBC, white blood cell; PLT, platelet count. For other abbreviations and statistical details, see Figure 1.
Fig. 3.
Effect of SBG on shear rates of whole blood viscosity of rats: A, low shear viscosity (LSV); B, medium shear viscosity (MSV), and C, high shear viscosity (HSV).
For other abbreviations and statistical details, see Figure 1.
Fig. 4.
Effect of SBG on NO (A), TNF-α (B), IL-6 (C), SOD (D), GSH-Px (E), MDA (F) and LDH (G) levels in serum of rats. NO, nitric oxide; TNF-α, tumor necrosis factor-α; IL-6, interleukin-6; SOD, superoxide dismutase; GSH-Px, glutathione peroxidase; MDA, malondialdehyde; LDH, lactate dehydrogenase. For other abbreviations and statistical details, see Figure 1.
Fig. 5.
Effect of SBG on histological structure of rats in (×200, ×400). A, B: control; C, D: Model group; E, F: Positive drug group; G, H: SBG-H dose group; I, J: SBG-M dose group; K, L: SBG-L dose group.
Stain: H & E. Magnification: A, C, E, G, I, K= 200X; B, D, F, H, J, L=400X.
Fig. 6.
Effect of SBG on western blot (A) and TLR4/β-actin (B), NF-κB p65/β-actin (C) protein expression levels kidney of rats. For other abbreviations and statistical details, see Figure 1.
October 2023
Pakistan J. Zool., Vol. 55, Iss. 5, pp. 2001-2500
