Protective Effects of Oviductus Ranae Mediated HPA Axis Regulation on Depressive Model of Mice
Xiaowei Huang1, Chao Ma1, He Lin1, Yuchen Wang1, Yan Xu1, Guangfu Lv2* and Zhe Lin1*
1School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun, 130117, China
2Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, 130117, China
Fig. 1.
Effect of OR on the contents of CRH, ACTH and CORT (A), the pathological changes in hippocampal tissues (magnification: 200×) (B), and the expression levels of proteins (C).
CRH, corticotropin-releasing hormone; ACTH, adrenocorticotrophic hormone; CORT, Corticosterone; BDNF, Brain-derived Neurotrophic Factor; TrkB, Trosine kinase B; CREB, Cyclic adenosine monophosphatec response element binding protein; GR, Glucocorticoid Receptor; MR, Mineralocorticoid Receptor. ##p<0.01, compared with control group; **p<0.01, compared with CUMS group.