Licofelone Inhibits Proliferation of Rat Hepatoma Cells
Licofelone Inhibits Proliferation of Rat Hepatoma Cells
Pinar Oztopcu-Vatan1, Gokhan Kus2, Emine Inan3, Melek Gunindi Korkut3, Selda Kabadere4,* and Ruhi Uyar4
Pinar Oztopcu-Vatan1, Gokhan Kus2, Emine Inan3, Melek Gunindi Korkut3, Selda Kabadere4,* and Ruhi Uyar4
Fig 1
Time and dose dependent effects of licofelone on survival rate of hepatoma cells after 24 and 48 h applications. C, Control (* p < 0.05, ** p < 0.01, *** p < 0.001).
Fig 2
The survival rates in percentage of hepatoma cells in culture after treatment with DMSO and different doses of 5-FU for 24 and 48 h.
Fig 3
Morphological appearance of H4IIE cells after treatment with three licofelone doses for 24 h (a, control; b, 150 µM; c, 200 µM; d, 250 µM; scale bar 50 µm; → shows rounded cells).
Fig 4
Typical quadrant analysis of Annexin V-FITC/PI flow cytometry of hepatoma cells that were treated for 24 h with three higher doses of licofelone.
Fig 5
Proportions of early apoptotic and late apoptotic/necrotic cells after exposure to high licofelone doses for 48 h
June 2017
Vol. 49, Iss. 3, Pages 761-1149
