Interaction of Strychni Semen Combined with Paeoniae Radix Alba after Transdermal Administration: Skin Permeation and Pharmacokinetics
Interaction of Strychni Semen Combined with Paeoniae Radix Alba after Transdermal Administration: Skin Permeation and Pharmacokinetics
Yun-Feng Liu, Yong-Mei Guan, Dan Chen, Jia-Le Chen, Chen Jin, Wei-Feng Zhu, Lu Wu and Li-Hua Chen*
ABSTRACT
Studies on the interaction of the active constituents after Strychni Semen combined with Paeoniae Radix Alba. Following transdermal administration to mouse, the content alterations in paeoniflorin after application of a combination of Strychni Semen extract (SSE) and Paeoniae Radix Alba extract (PRAE) by in vitro skin permeation were observed. The penetration quantity, infiltration rate and skin retention quantity of paeoniflorin in co-administrated with SSE were increased significantly (P<0.05). In the skin and brain, the peak concentration (Cmax) and the area under the concentration-time curve (AUC0→t) of brucine and strychnine in co-administrated with PRAE were decreased significantly (P<0.05), and the Cmax and AUC0→t of paeoniflorin in co-administrated with SSE increased significantly (P<0.05). These results showed that the co-administrated of SSE and PRAE can play an attenuation and synergistic effect.
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June 2020
Vol. 52, Iss. 3, Pages 825-1224
