Interaction of Strychni Semen Combined with Paeoniae Radix Alba after Transdermal Administration: Skin Permeation and Pharmacokinetics
Interaction of Strychni Semen Combined with Paeoniae Radix Alba after Transdermal Administration: Skin Permeation and Pharmacokinetics
Yun-Feng Liu, Yong-Mei Guan, Dan Chen, Jia-Le Chen, Chen Jin, Wei-Feng Zhu, Lu Wu and Li-Hua Chen*
Fig. 1.
Chemical structures of strychnine (a), brucine (b), and paeoniflorin (c).
Fig. 2.
In vitro mouse skin permeation profiles of paeoniflorin from different compatibility proportions.
Fig. 3.
Mean concentration-time profiles of the in vivo pharmacokinetic study after transdermal administration of different proportions of gels; (A): brucine in skin; (B): strychnine in skin; (C): brucine in brain; (D): strychnine in brain; (E): paeoniflorin in the skin; (F): paeoniflorin in the brain.
June 2020
Vol. 52, Iss. 3, Pages 825-1224
