In Vivo Effect of Novel Lytic Phage Cocktail against Salmonella Pullorum
In Vivo Effect of Novel Lytic Phage Cocktail against Salmonella Pullorum
Rida Haroon Durrani1, Ali Ahmad Sheikh1*, Masood Rabbani1, Muti-ur-Rehman Khan2, Aneela Zameer Durrani3, Salman Ashraf1, Muhammad Anas Naeem1, Muhammad Usman3 and Tauqeer Mahmood4
ABSTRACT
Despite advances, avian salmonellosis pose a major challenge to the poultry health, associated with high production losses. The study aimed to investigate the effect of oro-nasal phage delivery on bacterial population. As prophylaxis, oral phage delivery via drinking water and feed resulted in a significant (P ≤ 0.05) reduction in bacterial numbers with a mean log101.43, log101.17, log101.92 and log101.625 on 3rd and 6th dpc, respectively. The least reduction was seen in the birds that received cocktail intranasally showing log100.85 on the 3rd day. As a delayed treatment, oral delivery significantly (P ≤ 0.05) reduced count with a mean log101.2 and log101.55 on 3rd dpc, with efficiency decline on 6th dpc. No reduction was recorded for nasal delivery test subjects in delayed treatment group. As an immediate intervention, the oral delivery reduced bacterial count to log100.86 and log101.02 on the 3rd dpc. Phage-cocktail is promising pre-harvest biocontrol approach to curtail host-adaptive antibiotic resistant Salmonella.
To share on other social networks, click on any share button. What are these?
