Immunisation of Somatostatin DNA Vaccine in Ewes Can Affect Serum Somatostatin and Prolactin Levels in Offspring Lambs Through Maternal Related Hormones
Immunisation of Somatostatin DNA Vaccine in Ewes Can Affect Serum Somatostatin and Prolactin Levels in Offspring Lambs Through Maternal Related Hormones
Yan-Guo Han, Yu-Qing Han, Jia-Yuan Wu, Jia Guo, Ri-Su Na, Yan Zeng, Guang-Xin E, Yong-Ju Zhao and Yong-Fu Huang*
ABSTRACT
This study aimed to analysis the effect of immunisation of somatostatin (SS) DNA vaccine in maternal animals on serum related hormones in offspring. In this study, ten ewes with two newborn lambs were randomly divided into SS DNA vaccine group (Group T) and empty vector group (Group C), and these vaccines were given orally into the ewes at weeks 0, 3 and 6 of the research. Blood samples of ewes or offspring lambs were collected at week 6 or 9 of lactation, respectively. Serum SS, prolactin (PRL), growth hormone (GH) and insulin-like growth factor 1 (IGF-1) concentrations were detected by radioimmunoassay. The offspring lambs in T group showed significantly lower serum SS and higher PRL concentrations than those in the control group, and there were no difference between T group and the control group in terms of serum GH and IGF-1 concentrations. There was a significant negative correlation between offspring lambs serum SS and GH, IGF-1, PRL concentration, and there was a significant positive correlation between offspring lambs serum PRL and GH, IGF-1 concentration. There was a significant positive correlation between ewes serum SS concentration and offspring lambs serum SS concentration, ewes serum PRL concentration and offspring lambs serum PRL concentration. The findings indicate that the immunisation with oral somatostatin DNA vaccine in ewes may affect serum SS and PRL levels in offspring lambs through maternal related hormones.
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April 2020
Vol. 52, Iss. 2, Pages 425-824
