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Expression of Apoptosis Marker Genes bax and bcl-2 in WiDr Colon Cancer Cells Treated with Red Eye Sea Snail (Cerithidea obtusa) Extract

Expression of Apoptosis Marker Genes bax and bcl-2 in WiDr Colon Cancer Cells Treated with Red Eye Sea Snail (Cerithidea obtusa) Extract

Wisnu Jaka Dewa1,2, Ekowati Handharyani3*, Sri Purwaningsih4, Silmi Mariya5 

1Animal Biomedical Study Program, IPB Postgraduate School, IPB University, Bogor 16680, Indonesia; 2National Animal Health Training Centre, Ministry of Agriculture Republic of Indonesia, Cinagara, Bogor 16740, Indonesia; 3Department of Pathology, School of Veterinary Medicine and Biomedical Science, IPB University, Bogor 16680, Indonesia; 4Department of Aquatic Product Technology, Faculty of Fisheries and Marine Sciences, IPB University, Bogor 16680, Indonesia; 5Primatology Major, IPB Postgraduate School, IPB University, Bogor 16680, Indonesia.

*Correspondence | Ekowati Handharyani, Department of Pathology, School of Veterinary Medicine and Biomedical Science, IPB University, Bogor 16680, Indonesia; Email: ekowatieko@apps.ipb.ac.id  

Figure 1

Apoptotic gene expression in WiDr cells treated with red eye snail extract at 125 ppm, 62.5 ppm, and 31.25 ppm. Positive control using doxorubicin 0.01 ppm. Blue color: bax gene, red color: bcl-2 gene. 

Figure 2

Ratio between pro (bax) and anti (bcl-2) apoptotic genes of WiDr cell treated with red eye snail extract. 

Advances in Animal and Veterinary Sciences

May

Vol. 12, Iss. 5, pp. 802-993

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