Evaluation of Acute Toxicity, Antidepressant, Antioxidant Activities and Memory Ability of Curcuma longa Methanolic Extract in High fructose-treated rats
Evaluation of Acute Toxicity, Antidepressant, Antioxidant Activities and Memory Ability of Curcuma longa Methanolic Extract in High fructose-treated rats
Sara Brikat1*, Imane Kherrab1*, Yassine Taaifi2*, Sara Haida3, Laila Ibouzine-Dine1, Oumaima Abouyala1, Ilhame Fitah1, Abdelhalim Mesfioui1, Aboubaker Elhessni1
Experiment design of high fructose-treatment on 6 groups of female rats. C. Curcuma longa, F. fructose, L. losartan, PND. Postnatal day.
Inhibition percentage versus Ascorbic acid and methanolic Curcuma longa extract concentration for the DPPH reduction assay
Inhibition percentage versus Ascorbic acid and methanolic Curcuma longa extract concentration for the DPPH reduction assay
Organs weight rats taken after sacrifice after 14 days of acute toxicity of MECL. The results are represented by the mean ± SEM (n = 6). Dimethyl sulfoxide (DMSO).
Evaluation of the effect of the fructose, the MECL and losartan on the anxiety of rats in open fields. Number of central squares visited (A) and the time spent in the central cells (B) in the open field test. The results are represented by the mean ± SEM (n = 6), the statistical analyses were carried out by unidirectional ANOVA followed by Tukey’s post hoc test; the significance level is. * P <0.05, ** P <0.01, *** P <0.001, C. Curcuma longa, F. fructose, L. losartan.
Evaluation of the effect of the fructose, the MECL and losartan on anxiety like in the EPM. A: Number of entries into open arms. B: Time spent in open arms. The results are represented by the mean ± SEM (n = 6), the statistical analyzes were carried out by unidirectional ANOVA followed by Tukey’s post hoc test; the significance level is. * P <0.05, ** P <0.01, *** P <0.001. C. Curcuma longa, F. fructose, L. losartan.
Evaluation of the effect of the fructose, the MECL and losartan on the immobility time in the forced swimming test.
The results are represented by the mean ± SEM (n = 6), the statistical analyses were carried out by unidirectional ANOVA followed by Tukey’s post hoc test; the significance level is. * P <0.05, ** P <0.01, *** P <0.001. C. Curcuma longa, F. fructose, L. losartan.
Evaluation of the effect of the fructose, the MECL and losartan on the alternation percentage in the Y-MAZE test.
The results are represented by the mean ± SEM (n = 6), the statistical analyses were carried out by unidirectional ANOVA followed by Tukey’s post hoc test; the significance level is. * P <0.05, ** P <0.01, *** P <0.001. C. Curcuma longa, F. fructose, L. losartan.
Evaluation of the effect of the fructose, the MECL and losartan on the Recognition index in the object recognition test. The results are represented by the mean ± SEM (n = 6). C. Curcuma longa, F. fructose, L. losartan.
Evaluation of the effect of the fructose, the MECL and losartan on the time spent in the quadrant where the platform was located during the acquisition phase. The results are represented by the mean ± SEM (n = 6), the statistical analyses were carried out by unidirectional ANOVA followed by Tukey’s post hoc test; the significance level is. * P <0.05, ** P <0.01, *** P <0.001. C. curcuma longa, F. fructose, L. losartan.
