Evaluation of Acute Toxicity, Antidepressant, Antioxidant Activities and Memory Ability of Curcuma longa Methanolic Extract in High fructose-treated rats
Evaluation of Acute Toxicity, Antidepressant, Antioxidant Activities and Memory Ability of Curcuma longa Methanolic Extract in High fructose-treated rats
Sara Brikat1*, Imane Kherrab1*, Yassine Taaifi2*, Sara Haida3, Laila Ibouzine-Dine1, Oumaima Abouyala1, Ilhame Fitah1, Abdelhalim Mesfioui1, Aboubaker Elhessni1
ABSTRACT
Curcuma longa is a rhizomatous herbaceous plant used as a spice and food supplement, known for its valuable natural bioactive compounds. This study aims to investigate the acute toxicity, antidepressant effects, antioxidant activities, and memory enhancement potential of methanolic extract of Curcuma longa (MECL) in high fructose-treated rats. To assess acute toxicity, rats were divided into five groups treated with different doses of MECL (2000, 3000, and 4000 mg/kg) for 14 days. For the evaluation of antidepressant, antioxidant activities and memory performance, rats were randomly distributed into six groups included Control, Group (2) provided with a 23% fructose solution for one month; Group (3), administered 0.1 g/kg/d of MECL for 10 days, followed by fructose solution; Group (4) treated with 30 mg/kg/d of losartan for one month alongside a fructose solution; while Group (5), subjected to a combination of MECL, losartan, and a fructose-based diet, and finally a Group (6), receiving MECL and losartan supplementation. The MECL used contain 48.70% β-turmerone and 10.64% α-turmerone. For the 2000mg/kg group, no variation in clinical signs of toxicity was observed during the acute toxicity test. One month of fructose consumption led to the development of depressive and anxious behaviors as well as memory deficits, as revealed in various behavioral tests, including forced swimming test, open field test, elevated plus maze, Y-maze test and Morris water maze. Furthermore, the supplementation with MECL effectively mitigated the depressive behaviors and prevented the memory impairments induced by fructose consumption. Thus, the present study supports the use of Curcuma longa as a potential nutri-therapeutic agent in mood regulation and memory enhancement.
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