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Efficacy of Low-Dose Epinephrine in Treatment of Severe Asthma

Efficacy of Low-Dose Epinephrine in Treatment of Severe Asthma

Fengbin Jin1, Xin Liu2 and Yanqiu Yue3*

1Emergency Department, Qingdao Huangdao District Hospital of Traditional Chinese Medicine, Qingdao, Shandong 266500, China.
2Health Development Center of Qingdao West Coast New Area, Qingdao, Shandong 266500, China.
3Department of Renal and Pulmonary Diseases, Qingdao Huangdao District Hospital of Traditional Chinese Medicine, Qingdao, Shandong 266500, China.
 
* Corresponding author: yanqiuyue2021@gmail.com

ABSTRACT

The objective of this study was to explore the efficacy of 0.25 mg dose of epinephrine as a low-dose on the severe asthma. A total of 114 patients with severe asthma of hospital were selected between December 2017 and February 2020 as the subjects of this study and divided into the observation group and the control group randomly. Patients in the control group received the regular treatment, while those in the observation group received the treatment by low-dose epinephrine, and the efficacy of these two methods was compared between two groups. Besides, we compared the changes in the vital sign (including blood pressure and heart rate), blood-gas indicators and scores of symptoms before and after treatment between two groups. Additionally, we also observed the adverse reactions of patients in two groups. After treatment, the effectiveness rate of patients in the observation group and control group were 96.49% and 79.70%, and the difference had statistical significance (P < 0.05); besides, patients in two groups gained significant improvement in vital signs, while the improvement of patients in the observation group was much better than that in the control group (P < 0.05). Following the treatment, significant decreases were seen in the blood-gas indicators of patients in two groups, while the decrease in the observation group was much more obvious than that in the control group (P < 0.05). Similar changes were also observed in comparison of the clinical symptoms between two groups: Medication could significantly improve the symptoms of patients in two groups as compared to the status before medication, while the improvement in the observation group was much better than that in the control group (P < 0.05). As for the adverse events, there were 3 cases of allergy and 1 apnea, and the rate of adverse event was 7.02%, significantly lower than 21.05 in the control group (4 cases of allergy, 3 cases of apnea and 5 cases of shock) (P < 0.05). For patients with severe asthma, medication of low-dose epinephrine could stabilize the vital signs, improve the blood-gas indicators and relieve the patients form dysphoria, perspiration, wheezing rale and cyanosis, with fewer adverse reactions.

 

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Pakistan Journal of Zoology

October

Vol. 54, Iss. 5, Pages 2003-2500

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