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Effect of β- Human Chorionic Gonadotropin and Progesterone Monitoring on the Treatment of Ectopic Pregnancy with Methotrexate and Mifepristone

Effect of β- Human Chorionic Gonadotropin and Progesterone Monitoring on the Treatment of Ectopic Pregnancy with Methotrexate and Mifepristone

Tian Tian, Lili Luo*, Haiyan Wang and Lei Wang

First Hospotal of Jilin University, Changchun, 130021, China

*      Corresponding author: t1929t@163.com

ABSTRACT

The objective of this study was to observe and analyze the clinical value and nursing effect of β- human chorionic gonadotropin and progesterone monitoring on the treatment of ectopic pregnancy with methotrexate combined with mifepristone. One hundred and eighty patients with ectopic pregnancy were included in the study, all of whom were treated with methotrexate combined with mifepristone tablets. According to the treatment results, they were divided into treatment success group and the treatment failure group, each containing with 90 cases. The levels of β- human chorionic gonadotropin and progesterone in the two groups were compared.Of the 180 patients, 168 were cured successfully, 12 were failed, and the success rate and failure rate were 93.33% and 6.67%, respectively. After treatment, serum β- human chorionic gonadotropin and progesterone levels in the successful group decreased more significantly as compared with that before treatment, p<0.05. When the levels of β-human chorionic gonadotropin and progesterone were increased, the success rate of methotrexate combined with mifepristone tablets showed a decreasing trend, p<0.05. When the maximum diameter value of pelvic effusion was increased, the success rate of conservative treatment with methotrexate combined with mifepristone tablets showed a decreasing trend, p<0.05. The risk factors that affect the success rate of methotrexate combined with mifepristone tablets are β-human chorionic gonadotropin level and progesterone level. To conclude β- human chorionic gonadotropin and progesterone monitoring is a key step for treatment of ectopic pregnancy. Combined monitoring is of great significance in predicting the success of conservative treatment of ectopic pregnancy.
 

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Pakistan Journal of Zoology

December

Vol. 53, Iss. 6, Pages 2001-2521

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