Comparative Efficacy of Newcastle Disease’s Live Vaccines in Broilers Using Hemagglutination Inhibition (HI) Test at Jaba Mansehra
Comparative Efficacy of Newcastle Disease’s Live Vaccines in Broilers Using Hemagglutination Inhibition (HI) Test at Jaba Mansehra
Ayesha Bakhtiar1, Sardar Azhar Mehmood2, Abdul Rauf Bhatti3*, Shabir Ahmad2, Naqash Khalid2, Javed Iqbal5, Azra Nadeem4 and Waqas Ahmad1
ABSTRACT
Two commercial vaccines against the Lasota strain of Newcastle disease (ND), the Lasota vaccine-1 and vaccine-2, and two vaccines against the Mukteswar strain of Newcastle disease, the Mukteswar vaccine-1 and vaccine-2, were assessed for their effectiveness and impact on the productivity of broilers. 75 days old broiler chicks overall were divided into five equal groups and given the following labels: A, B, C, D, and E. Each group was then split up into pens with a maximum of five birds in each pen. On days 14 and 21, the birds in groups B, C, D, and E received active immunisation against ND using Lasota-1, Lasota-2, Mukteswar-1, and Mukteswar-2, respectively, leaving A as the control group left uninfected. On days 21 and 35 of the study, the serum HI antibody response to these four immunisations was assessed. As evidence of its strong efficacy, Group C, which had received the Lasota (vaccine-2) vaccination, displayed high antibody titers throughout the experiment. In terms of geometric mean titers, there was a significant difference (p 0.05) between the groups. On days 7, 14, 21, and 35 of the experiment, data on other performance indicators, including as feed intake, water intake, total body weight, and feed conversion ratio (FCR), were gathered. Throughout the course of the trial, there were significant differences in these performance metrics (p 0.05). There was no discernible difference in the productive performance of the broilers between the vaccinated groups, and the unvaccinated broilers (control group) performed better in terms of weight growth and FCR than the vaccinated groups. According to the data, group C of broilers given Lasota vaccine-2 proved to be more effective in terms of producing antibodies in broilers, while unvaccinated broilers performed better in terms of productivity compared to the vaccinated flock. However, it was advised that the decision on which vaccine to use depend not only on the aforementioned elements but also on the specifics of a given region, including the organization of veterinary services, prior knowledge, population distribution, communication infrastructure, and climate.
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