Anti-Inflammatory Activity of Clove (Syzygium aromaticum) Oil Extract Against Chronic Inflammation in Rat
Anti-Inflammatory Activity of Clove (Syzygium aromaticum) Oil Extract Against Chronic Inflammation in Rat
Rana Mahmood Ahmad*, Orooba Mohammed Maeed Ibrahim
Clove oil extract.
Phytochemicals analysis of S. aromaticum essential oil by GC-MS.
Show the Pus and granuloma after implanted Cotton Pellet A: Positive control, B: treated with clove oil extract 10 mg/kg, C: treated with piroxicam 5mg/kg.
TNF-α concentration in serum (pg/ml) values after nine days on cotton pellet granuloma in rat treated with clove oil and piroxicam.
Photomicrograph in AandB: G1 (control positive group): Overexpression of TNF-α in fibroblasts (black arrow) and macrophages (yellow arrow) in dermis layer of affected area. Note, massive expression of TNF-αcovered more than 75% of tissue area. Also, the affected dermis layer showed deposition of collagen fibers due to chronic inflammation. C and D: (G2) Weak of TNF-αin fibroblasts (black arrow) and macrophages (yellow arrow) in dermis layer of affected area. Note, expression of TNF-α covered less than 20% of tissue area. EandF: (G3) Moderate expression of TNF-α in fibroblasts (black arrow) and macrophages (yellow arrow) in dermis layer of affected area. Note, expression of TNF-α covered more than 30% of tissue area. DAB and Hematoxylin. A,C,E: 100x and B, D, F: 400x.
TNF-α score.
IL-10 concentration in serum (pg/ml) values after nine days on cotton pellet granuloma in rat treated with clove oil and piroxicam.
