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Interference in Innate Immunity: Another Dimension in ICP0 Multi-functionality

Interference in Innate Immunity: Another Dimension in ICP0 Multi-functionality

Kathryne E. Taylor1 and Karen L. Mossman1,2*

1Departments of Biochemistry and Biomedical Sciences; 2Pathology and Molecular Medicine, McMaster Immunology Research Centre, Institute for Infectious Disease Research, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada

ABSTRACT

The literature regarding the ICP0 protein from herpes simplex virus is complex and frequently contradictory, meaning that although this protein has been implicated in a wide variety of diverse functions, the mechanisms through which it produces these effects continue to be elusive. Recent investigations into the ability of ICP0 to block the activation of antiviral signaling have revealed a potential explanation for some of this confusion – namely, that ICP0 has important functions in the cytoplasm that have been generally disregarded, due to the fact that many frequently used experimental manipulations restrict this protein to the nucleus. This commentary discusses the significance of these findings to the ICP0 field.

 

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Hosts and Viruses

June

Vol.6, Iss.3, Pages 42-84

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