Search for Silymarin

Comparative Effect of Zinc Oxide and Silymarin on Growth, Nutrient Utilization and Hematological Parameters of Heat Distressed Broiler

Asad Sultan¹, Sahal Ahmad¹, Sarzamin Khan¹, Rifat Ullah Khan^2,*, Naila Chand¹, Muhammad Tahir³ and Shakoor Ahmad²

...etary supplementation of silymarin (Silybum marianum) and zinc oxide (ZnO) in broilers during the finishing stage exposed to heat stress (HS). Two hundred and seventy broiler chicks were randomly assigned to 6 dietary groups: three dietary groups in thermoneutral temperature (TN) and three dietary groups under high temperature. One group of birds received a basal diet only (control group), second group of birds received a diet supplemented with

An In Vitro Assessment of the Cytotoxic and Apoptotic Potency of Silymarin and Silymarin Loaded Solid Lipid Nanoparticles on Lung and Breast Cancer Cells

Canan Vejselova Sezer*

...ent of a different type, silymarin-loaded solid lipid nanoparticles and investigation of its effectiveness on treatment of lung and breast cancers. In this respect, these nanoparticles and silymarin were elucidated by using MTT assay for cytotoxicity, annexin-V analyses for cell death mechanism and confocal and transmission electron microscopies for morphological and ultrastructural changes. Based upon our findings, it can b...

Antiviral Diversity of Compounds Derived From Silybum marianum

Hanaa H. A. Gomaa1; Entsar A. A. Nassar2; K. A. El-Dougdoug3

...amount of seven detected silymarin compounds using HPLC showed wide variations among varieties. They ranged from 9.2 to 34.78 mg/g fruits or 450.25 to 1250.25 mg/plant. The silymarin production has the same pattern of fruits yield. The methanolic solutions were extracted from milk thistle varieties then evaluated against HAV, HSV1 and COXB4 viruses. The cytotoxicity of different milk thistle methanolic extracts in Vero cells...

Protective Effect of Walnut Oil on Alcoholic Liver Disease in Mice

Fujun Miao¹, Chunlan Shan², Wei Yang³, Hao Wang³, Shuxiang Geng¹ and Delu Ning¹*

...oil (ETH + WO) and ETH + silymarin positive group (PC) groups significantly decreased, and the lesions of ethanol-induced liver injury were relieved compared with the ethanol (ETH) group. Walnut oil significantly increased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the liver of ALD. Walnut oil exerted the anti-inflammatory effects in the liver of ALD by decreasing the liver index, malondialdehyde (MDA) contents, and the...

Regulatory Effects of Garlic Extract (Allium sativum L.) on Hematobiochemical Markers in Rabbits Intoxicated with Paracetamol

Bashir Ahmad¹*, Ali Muhammad Yousafzai², Waqar Ali¹, Ikram Ilahi¹, Farman Ullah³, Saeed Ahmad¹, Ayaz Ali Khan¹, Umair Ahmad² and Hafsa Maria²

...atoprotective medication silymarine (50 mg/kg body weight). When contrasted to toxic control rabbits, the highest dose of garlic aqueous extract i.e. 300 mg/kg b.w excellently decreased the high serum rates of alkaline phosphatase (ALP), alanine transaminase (ALT), and aspartate transaminase (AST). The outcomes of the extract-treated rabbits were comparable to those of the group of rabbits given silymarine. RBC, platelets, h...

Comparative Effectiveness of Silymarin and Choline Chloride (Liver Tonics) in Preventing the Effects of Aflatoxin B1 in Broiler Chicks

Saad Zaghlou El-Damrawy1, Reda Ali Hassan2*, Ahmed Maher Bakhaty1, Adel M. Nasr2, El-Sayed A. Abu El-Hassan2

...) NC + 600 mg/kg diet of silymarin, (3) NC + 400 mg/kg diet of choline, (4) Positive control (PC) containing 1 mg AFB1/kg diet, (5) PC + 600 mg/kg diet of silymarin and (6) PC + 400 mg/kg diet of choline. The findings show that the AFB1-treated chicks’ growth characteristics dramatically decreased. While total antioxidant capacity (TAC) dropped as a result of AFB1, serum levels of alanine aminotransferase (ALT), aspart...

Effect of Different Concentrations of Silymarin on Performance and Selected Physiological Traits in Local Lambs

Tamara Natik Dawood*

...nce of several levels of silymarin on the productive and biochemical parameters in local lambs. A total of 30 lambs are classified into three groups. G1 (ten lambs) received Silymarin (420 mg/kg) orally, G2 (ten lambs) received Silymarin (210 mg/kg) orally, while G3 (ten lambs) received distal water (control group). Several parameters are used in the current study to evaluate

Hepatoprotective Effects of Tamarix dioica Leaf Extracts on Paracetamol-Induced Hepatotoxicity in Mice

Tahani Ahmad Al-Matrafi¹, Zuhair M. Mohammedsaleh², Mamdoh S. Moawadh², Waheeb S. Aggad³, Rawabi Mohamed almuhimed⁴, Zamzam Alhuwaymil⁵, Aishah E Albalawi⁶, Ifat Alsharif⁷, Hailah M. Almohaimeed⁸, Fatima S. Alaryani⁹ and Mona H. Soliman^10,11*