Comparative Effectiveness of Silymarin and Choline Chloride (Liver Tonics) in Preventing the Effects of Aflatoxin B1 in Broiler Chicks
Comparative Effectiveness of Silymarin and Choline Chloride (Liver Tonics) in Preventing the Effects of Aflatoxin B1 in Broiler Chicks
Saad Zaghlou El-Damrawy1, Reda Ali Hassan2*, Ahmed Maher Bakhaty1, Adel M. Nasr2, El-Sayed A. Abu El-Hassan2
ABSTRACT
The purpose of this study was to compare the effectiveness of two distinct liver tonics (Silymarin and Choline chloride) against aflatoxin B1 (AFB1), as well as the impacts of AFB1 on the growth performance, liver weight, haematological, and serum biochemical responses of broiler chicks. Six nutritional treatment groups with equal numbers of birds each were created. In a randomized complete block design experiment, each group contained 100 birds in five repetitions and was assigned to one of the six feeding regimens. Experimental groups included: (1) Negative control (NC) with the basal diet, (2) NC + 600 mg/kg diet of silymarin, (3) NC + 400 mg/kg diet of choline, (4) Positive control (PC) containing 1 mg AFB1/kg diet, (5) PC + 600 mg/kg diet of silymarin and (6) PC + 400 mg/kg diet of choline. The findings show that the AFB1-treated chicks’ growth characteristics dramatically decreased. While total antioxidant capacity (TAC) dropped as a result of AFB1, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), uric acid, creatinine, and malnodialdhyde (MDA) dramatically rose. After 35 days of feeding, AFB1-treated chicks showed a significant decrease in their total erythrocyte count (TEC), total leukocyte count (TLC), haemoglobin concentration (Hb), haematocrit levels (HCT), mean corpuscular haemoglobin (MCH), mean corpuscular volume (MCV), and mean corpuscular haemoglobin concentration (MCHC), as well as lymphocyte %, neutrophil %, and monocyte %. All the indicators, including feed intake, body weight gain, haematological tests, and serum biochemical tests, were significantly (p<0.05) enhanced by both liver tonics. The study concluded that silymarin or choline can be effectively used to decrease the adverse effects of AF in broiler chicken. However, silymarin comparatively more efficiently ameliorate the effects induced by AFB1 than choline chloride.
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