Wound Healing Effectiveness Test of Dermal Patch Formulated with Green Synthesized Silver Nanoparticles from Plantago major L. Extract
Johan Sukweenadhi1*, Stefan Pratama Chandra1, Finna Setiawan2, Christina Avanti2, Kartini Kartini2, Arief Koeswanto3 and Deok-Chun Yang4
1Department of Plant Biology, Faculty of Biotechnology, University of Surabaya, Jalan Raya Kalirungkut, Kalirungkut, Surabaya, East Java 60293, Indonesia; 2Department of Pharmaceutics, Faculty of Pharmacy, University of Surabaya, Jalan Raya Kalirungkut, Kalirungkut, Surabaya, East Java 60293, Indonesia; 3PT Kurnia Cahaya Teknik, Jakarta 14410, Indonesia; 4Graduate School of Biotechnology, College of Life Science, Kyung Hee University, Yongin-si, Gyeonggi-do 17104, Republic of Korea.
*Correspondence | Johan Sukweenadhi, Department of Plant Biology, Faculty of Biotechnology, Universirty of Surabaya, Jalan Raya Kalirungkut, Kalirungkut, Surabaya, East Java 60293, Indonesia;
Email: [email protected]
Figure 1:
Bar chart to show the average fasting blood glucose of mice for each treatment on day-0 and day-7 after STZ injection. The difference in letters indicates a significant difference between the treatment groups (α = 5%).
Figure 2:
Bar chart to show average of wound area on each group for day 0, day 4, day 8, day 12, and day 14. The difference in letters indicates a significant difference between the treatment groups (α = 5%).
Figure 3:
Bar chart to show average of epidermal reconstruction on each group for day 0, day 4, day 8, day 12, and day 14. The difference in letters indicates a significant difference between the treatment groups (α = 5%).
Figure 4:
Bar chart to show average of TIME-H on each group for day 0, day 4, day 8, day 12, and day 14. The difference in letters indicates a significant difference between the treatment groups (α = 5%).
Figure 5:
Bar chart to show the average fasting blood glucose of mice for each treatment before effectiveness test and after effectiveness test. The difference in letters indicates a significant difference between the treatment groups (α = 5%).
Table 2:
The appearance of wounds in each group on 0 to 14 days during the dermal patch effectiveness test.
Based on statistical analysis, the average epidermal reconstruction for each group did not significantly differ from day 0 to day 8. Significant differences occurred on day 12 and day 14. The average epidermal reconstruction of the normal, induction ACA, induction ACA Ag, induction DPP and induction DP0005 groups were significantly different than the induction DP001 and induction groups. There was no significant difference between the normal, induction ACA, induction ACA Ag, induction DPP, and induction DP0005 groups and there was no significant difference between the induction and the induction DP001 group.