Fig. 4. A:
The red node represents H(E16) 1, Dilated cardiomyopathy (DCM); 2, Axon guidance; 3, Hypertrophic cardiomyopathy (HCM); 4, Arrhythmogenic right ventricular cardiomyopathy (ARVC); 5, Cardiac muscle contraction; 6, Cell adhesion molecules (CAMs); 7, Adrenergic signaling in cardiomyocytes; 8, Glutamatergic synapse; 9, Breast cancer; 10, GABAergic synapse; 11, ECM-receptor interaction; 12, MAPK signaling pathway; 13, Basal cell carcinoma; 14, Hippo signaling pathway; 15, Morphine addiction; 16, Pathways in cancer; 17, Signaling pathways regulating pluripotency of stem cells; 18, cGMP-PKG signaling pathway; 19, Taste transduction; 20, TGF-beta signaling pathway; 21, Cholinergic synapse; 22, Nicotine addiction; 23, Rap1 signaling pathway; 24, Herpes simplex virus 1 infection; 25, Ras signaling pathway; 26, Wnt signaling pathway; 27, Cushing syndrome; 28, Central carbon metabolism in cancer; 29, Retrograde endocannabinoid signaling; 30, PI3K-Akt signaling pathway; 31, Protein digestion and absorption; 32, Oxytocin signaling pathway; 33, Vascular smooth muscle contraction; 34, Circadian entrainment; 35, cAMP signaling pathway; 36, Aldosterone synthesis and secretion; 37, Gastric cancer; 38, Calcium signaling pathway; 39, Apelin signaling pathway; 40, Melanogenesis; 41, Leukocyte transendothelial migration; 42, Focal adhesion; 43, Cortisol synthesis and secretion.
B: The blue node represents H(E16). 1, Protein digestion and absorption; 2, PPAR signaling pathway; 3, Cholesterol metabolism; 4, Platelet activation; 5, Complement and coagulation cascades; 6, Fc gamma R-mediated phagocytosis; 7, Hematopoietic cell lineage; 8, Ferroptosis; 9, Malaria; 10, Fat digestion and absorption; 11, Aldosterone-regulated sodium reabsorption; 12, p53 signaling pathway; 13, Osteoclast differentiation; 14, Epstein-Barr virus infection; 15, Proteoglycans in cancer; 16, Pantothenate and CoA biosynthesis; 17, Collecting duct acid secretion; 18, Chagas disease (American trypanosomiasis); 19, African trypanosomiasis; 20, Phagosome; 21, Chemical carcinogenesis; 22, Arachidonic acid metabolism; 23, Histidine metabolism; 24, B cell receptor signaling pathway; 25, Tyrosine metabolism; 26, Salmonella infection; 27, Lysosome; 28, Kaposi sarcoma-associated herpesvirus infection; 29, Phosphatidylinositol signaling system; 30, Regulation of actin cytoskeleton; 31, Human cytomegalovirus infection; 32, Phenylalanine metabolism; 33, Platinum drug resistance; 34, Mineral absorption; 35, NF-kappa B signaling pathway; 36, Human immunodeficiency virus 1 infection; 37, Fructose and mannose metabolism; 38, Riboflavin metabolism; 39, Drug metabolism - cytochrome P450; 40, Glutathione metabolism; 41, PI3K-Akt signaling pathway; 42, Adipocytokine signaling pathway; 43, Glioma; 44, Hepatitis B; 45, Transcriptional misregulation in cancer; 46, Glycolysis/ Gluconeogenesis; 47, AMPK signaling pathway; 48, Prolactin signaling pathway; 49, Tuberculosis; 50, Toll-like receptor signaling pathway; 51, Rheumatoid arthritis; 52, Porphyrin and chlorophyll metabolism; 53, Steroid hormone biosynthesis; 54, C-type lectin receptor signaling pathway; 55, Apoptosis; 56, Drug metabolism other enzymes; 57, Amoebiasis; 58, Jak-STAT signaling pathway; 59, Hepatitis C; 60, Endocrine resistance; 61, T cell receptor signaling pathway; 62, Bacterial invasion of epithelial cells; 63, Leukocyte transendothelial migration; 64, Viral carcinogenesis; 65, Amphetamine addiction; 66, Melanoma; 67, Natural killer cell mediated cytotoxicity; 68, Metabolism of xenobiotics by cytochrome P450. Green nodes represent specific pathways.
